Abstract:
:The great majority of infections caused by the pandemic variant of the influenza virus (nvH1N1) are self-limited, but a small percentage of patients develop severe symptoms requiring hospitalization. Bermejo-Martin and colleagues have presented a pilot study describing the differences in the early immune response for patients both mildly and severely infected with nvH1N1. Patients who develop severe symptoms after nvH1N1 infection showed Th1 and Th17 'hypercytokinemia', compared to mildly infected patients and healthy controls. The mediators involved with the Th1 and Th17 profiles are known to be involved in antiviral, pro-inflammatory and autoimmune responses. This is the first work reporting the association of a pro-inflamatory immune response with a severe pandemic infection, although it is likely that more studies are needed to understand the detrimental or beneficial roles these cytokines play in the evolution of mild and severe nvH1N1 infection.
journal_name
Crit Carejournal_title
Critical care (London, England)authors
de Castro IF,Guzmán-Fulgencio M,García-Alvarez M,Resino Sdoi
10.1186/cc8846subject
Has Abstractpub_date
2010-01-01 00:00:00pages
115issue
1eissn
1364-8535issn
1466-609Xpii
cc8846journal_volume
14pub_type
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