Abstract:
:The rationale for the provision of nitrogen from proteins given via the enteral route or from intravenous amino acids is to boost the synthesis of muscle proteins, and thereby to limit the severity of intensive care unit-acquired weakness by the prevention of muscle loss. However, the optimal timing for supplemental nitrogen provision is a matter of debate and controversy. Indeed, consistent data from retrospective studies support an association between high early protein intakes and better outcomes, while recent post-hoc findings from prospective studies raise safety concerns. This pro-con paper details the arguments of both sides and highlights the need for large-scale prospective studies assessing the safety and efficacy of different levels of protein intake in combination with physical activity and summarizes the currently recruiting clinical trials.
journal_name
Crit Carejournal_title
Critical care (London, England)authors
Preiser JCdoi
10.1186/s13054-018-2196-5subject
Has Abstractpub_date
2018-10-25 00:00:00pages
261issue
1eissn
1364-8535issn
1466-609Xpii
10.1186/s13054-018-2196-5journal_volume
22pub_type
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