Abstract:
:Many advances in medicine have been achieved through challenging established dogma with revolutionary thought and novel practices. Each and every specialty is reinvigorated by regular re-evaluation of processes and practices in the light of new evidence and fresh conceptualization. Challenge can galvanize fresh thinking and new approaches, yet may also reinforce and strengthen traditional paradigms if the prevailing orthodoxy is subsequently revalidated. This article is a synopsis of a roundtable meeting held in Brussels in March 2010 designed specifically to confront doctrine with reasoned scientific argument, and to propose new ideas for advancing critical care practices and outcomes.
journal_name
Crit Carejournal_title
Critical care (London, England)authors
Singer M,Matthay MAdoi
10.1186/cc10245subject
Has Abstractpub_date
2011-07-26 00:00:00pages
225issue
4eissn
1364-8535issn
1466-609Xpii
cc10245journal_volume
15pub_type
杂志文章,评审相关文献
CRITICAL CARE文献大全abstract:INTRODUCTION:Little is known about mortality rates following general surgical procedures in the United Kingdom. Deaths are most common in the 'high-risk' surgical population consisting mainly of older patients, with coexisting medical disease, who undergo major surgery. Only limited data are presently available to desc...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc4928
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:In hospitalised patients, anaemia increases the risk of developing acute kidney injury (AKI). Our aim was to determine whether anaemia also has an impact on the risk of progression from early AKI to more severe AKI in critically ill patients. METHODS:We retrospectively analysed the data of patients admitted...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1231-7
更新日期:2016-03-08 00:00:00
abstract:INTRODUCTION:V(2)-receptor (V(2)R) stimulation potentially aggravates sepsis-induced vasodilation, fluid accumulation and microvascular thrombosis. Therefore, the present study was performed to determine the effects of a first-line therapy with the selective V(2)R-antagonist (Propionyl(1)-D-Tyr(Et)(2)-Val(4)-Abu(6)-Arg...
journal_title:Critical care (London, England)
pub_type: 杂志文章,随机对照试验
doi:10.1186/cc9320
更新日期:2010-01-01 00:00:00
abstract::Respiratory tract obstruction due to a blood clot may result in life threatening ventilatory impairment. Ball valve blood clot obstructions of the airways are rare. A ball valve blood clot acts as a one-way valve, allowing (near) normal air entry into the airways, but (completely) blocking expiration. In a near fatal ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc2903
更新日期:2004-10-01 00:00:00
abstract::ICU delirium is associated with poor patient outcome. Risk factor stratification is essential to the understanding, prevention and treatment of this disorder. Alcohol consumption, smoking and prior cognitive impairment appear strongly correlated with delirium risk. Several potentially modifiable associations deserve p...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc7917
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Mechanical ventilators are increasingly used in critical care units. However, they can cause lung injury, including pulmonary edema. Our previous studies indicated that γ-aminobutyric acid (GABA) receptors are involved in alveolar-fluid homeostasis. The present study investigated the role of GABA receptors...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc11298
更新日期:2012-12-12 00:00:00
abstract:INTRODUCTION:Appropriate care for patients with tracheostomies in hospital settings is an important issue. Each year more than 7000 patients receive tracheostomies in Australia and New Zealand alone. Many of these tracheostomy patients commence their care in the intensive care unit (ICU) and once stabilised are then tr...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc8159
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Chemokine (C-X3-C motif) receptor 1 (CX3CR1) was identified as the most differentially expressed gene between survivors and non-survivors in two independent cohorts of septic shock patients and was proposed as a marker of sepsis-induced immunosuppression. Whether such a biomarker is associated with mortality...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1362-x
更新日期:2016-06-30 00:00:00
abstract:BACKGROUND:Critical illness myopathy is an acquired skeletal muscle disorder with severe myosin loss and muscle weakness frequently seen in intensive care unit (ICU) patients. It is unknown if impaired excitation-contraction coupling contributes to the muscle weakness. METHODS:We used a unique ICU model where rats wer...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1417-z
更新日期:2016-08-10 00:00:00
abstract:INTRODUCTION:Refractory status epilepticus (RSE) secondary to traumatic brain injury (TBI) may be under-recognized and is associated with significant morbidity and mortality. METHODS:This case report describes a 20 year old previously healthy woman who suffered a severe TBI as a result of a motor vehicle collision and...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc3884
更新日期:2005-01-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to assess the volume of gas being poorly ventilated or non-ventilated within the lungs of patients treated with mechanical ventilation and suffering from acute respiratory distress syndrome (ARDS). METHODS:A prospective, descriptive study was performed of 25 sedated and paralysed...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc3058
更新日期:2005-04-01 00:00:00
abstract:INTRODUCTION:Bacterial meningitis (BM) is a severe complication in patients with aneurysmal subarachnoid haemorrhage (SAH). Clinical signs of meningitis are often masked by SAH-related symptoms, and routine cerebrospinal fluid (CSF) analysis fails to indicate BM. Microdialysis (MD) is a technique for monitoring cerebra...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7689
更新日期:2009-01-01 00:00:00
abstract::Prior to 2001 there was no standard for early management of severe sepsis and septic shock in the emergency department. In the presence of standard or usual care, the prevailing mortality was over 40-50 %. In response, a systems-based approach, similar to that in acute myocardial infarction, stroke and trauma, called ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-016-1288-3
更新日期:2016-07-01 00:00:00
abstract::Urgent cardiac ultrasound examination in the critical care setting is clinically useful. Application of goal-directed echocardiography in this setting is quite distinct from typical exploratory diagnostic comprehensive echocardiography, because the urgent critical care setting mandates a goal-directed approach. Goal-d...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-014-0681-z
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:(1,3)-β-D-Glucan has been widely used in clinical practice for the diagnosis of invasive Candida infections. However, such serum biomarker showed potential to guide antimicrobial therapy in order to reduce the duration of empirical antifungal treatment in critically ill septic patients with suspected invasiv...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03265-y
更新日期:2020-09-05 00:00:00
abstract:INTRODUCTION:Sepsis biomarkers can have important diagnostic, therapeutic, and prognostic functions. In a previous review, we identified 3370 references reporting on 178 different biomarkers related to sepsis. In the present review, we evaluate the progress in the research of sepsis biomarkers. METHODS:Using the same ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-020-02993-5
更新日期:2020-06-05 00:00:00
abstract::The composition and function of intestinal microflora are emerging as integral to both health and disease. During critical illness the normal microbiota are rapidly replaced by pathogenic species as a result of both the physiologic stress itself and the use of antibiotics. In this report, the authors use fecal pH as a...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc11474
更新日期:2012-09-12 00:00:00
abstract::The European Clinical Trials Directive requires an informed consent from the patient or a proxy in drug trials. Although informed consent is a valuable tool to protect patients' rights in clinical trials, this requirement largely impedes research in critical care settings, and if pursued in this context, it does not p...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc10113
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Expert systems can help alleviate problems related to the shortage of human resources in critical care, offering expert advice in complex situations. Expert systems use contextual information to provide advice to staff. In mechanical ventilation, it is crucial for an expert system to be able to determine the...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1436-9
更新日期:2016-08-14 00:00:00
abstract::This commentary on a paper by Bendel and colleagues in the previous issue of Critical Care describes the difficulty in assessing the sufficiency of adrenal responses to endogenous, stress-induced adrenocorticotropic hormone (ACTH) release by the pituitary or to exogenous ACTH administration in the critically ill patie...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章,评审
doi:10.1186/cc7131
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:The incidence of seizures in intensive care units ranges from 3.3% to 34%. It is therefore often necessary to initiate or continue anticonvulsant drugs in this setting. When a new anticonvulsant is initiated, drug factors, such as onset of action and side effects, and patient factors, such as age, renal, and...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-018-2066-1
更新日期:2018-06-07 00:00:00
abstract:INTRODUCTION:There has been dramatic improvement in survival for patients with HIV/AIDS; however, some studies on patients with HIV/AIDS and serious illness have reported continued low rates of intensive care. The purpose of this study was to examine patterns of care and outcomes for patients with severe sepsis and HIV...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc3811
更新日期:2005-01-01 00:00:00
abstract::Large numbers of patients who survive critical illness are left with significant new cognitive impairments that are often severe and remain years after hospital discharge. In the previous issue of Critical Care, Guerra and colleagues assessed risk factors for the development of dementia after an intensive care unit (I...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc11913
更新日期:2013-02-06 00:00:00
abstract::Recent interest in transfusion management of trauma patients has heightened expectation in the role of blood component therapy in improving patient outcome. Optimal transfusion support in supplementation with fibrinogen has not been defined by high-quality evidence. Current evidence comes mainly from case series and u...
journal_title:Critical care (London, England)
pub_type: 评论,社论
doi:10.1186/cc10510
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Delirium occurs in most ventilated patients and is independently associated with more deaths, longer stay, and higher cost. Guidelines recommend monitoring of delirium in all intensive care unit (ICU) patients, though few data exist in non-ventilated patients. The study objective was to determine the relat...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc3729
更新日期:2005-08-01 00:00:00
abstract::The encouraging results of recent clinical trials on therapy of severe sepsis and septic shock are paralleled by ongoing studies on the epidemiology of sepsis and infection in intensive care unit patients all over the world. The development of network-based systems for assessing morbidity and mortality in intensive ca...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc2175
更新日期:2003-10-01 00:00:00
abstract:INTRODUCTION:Down-regulation of ex-vivo cytokine production is a specific feature in patients with sepsis. Cytokine downregulation was studied focusing on caspase-1 activation and conversion of pro-interleukin-1β into interleukin-1β (IL-1β). METHODS:Peripheral blood mononuclear cells were isolated from a) 92 patients ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc9974
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Evidence suggests that dying patients' physical and emotional suffering is inadequately treated in intensive care units. Although there are recommendations regarding decisions to forgo life-sustaining therapy, deciding on withdrawal of life support is difficult, and it is also difficult to decide who shoul...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc9390
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:Hemorrhagic shock induced O2 deficit triggers inflammation and multiple organ failure (MOF). Endogenous H2S has been proposed to be involved in MOF since plasma H2S concentration appears to increase in various types of shocks and to predict mortality. We tested the hypothesis that H2S increases during hemo...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc11661
更新日期:2012-10-02 00:00:00
abstract:INTRODUCTION:The use of human recombinant activated protein C (rhAPC) for the treatment of severe sepsis remains controversial despite multiple reported trials. The efficacy of rhAPC remains a matter of dispute. We hypothesized that patients with septic shock who were treated with rhAPC had an improved in-hospital mort...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc10089
更新日期:2011-01-01 00:00:00