Prognostic value of admission blood glucose level in patients with and without diabetes mellitus who sustain ST segment elevation myocardial infarction complicated by cardiogenic shock.

abstract：:This narrative review summarizes the role of vitamin C in mitigating oxidative injury-induced microcirculatory impairment and associated organ failure in ischemia/reperfusion or sepsis. Preclinical studies show that high-dose vitamin C can prevent or restore microcirculatory flow impairment by inhibiting activation of...

journal_title：Critical care (London, England)

authors： Oudemans-van Straaten HM,Spoelstra-de Man AM,de Waard MC

更新日期：2014-08-06 00:00:00

abstract：:The recent bus crash in Switzerland involving many children provides several lessons for the pre-hospital care community. The use of multiple helicopters that are capable of flying at night and that carry advanced medical pre-hospital teams undoubtedly saved lives following the tragedy. We describe the medical respons...

journal_title：Critical care (London, England)

authors： Lyon RM,Sanders J

更新日期：2012-07-11 00:00:00

abstract：INTRODUCTION:In severely neutropenic septic acute respiratory distress syndrome (ARDS) patients, macrophages and monocytes are the last potentially remaining innate immune cells. We have previously shown, however, a deactivation of the alveolar macrophage in neutropenic septic ARDS patients. In the present study, we tr...

journal_title：Critical care (London, England)

authors： Mokart D,Kipnis E,Guerre-Berthelot P,Vey N,Capo C,Sannini A,Brun JP,Blache JL,Mege JL,Blaise D,Guery BP

更新日期：2008-01-01 00:00:00

abstract：:Characteristic patterns of variation over time, namely rhythms, represent a defining feature of complex systems, one that is synonymous with life. Despite the intrinsic dynamic, interdependent and nonlinear relationships of their parts, complex biological systems exhibit robust systemic stability. Applied to critical ...

journal_title：Critical care (London, England)

authors： Seely AJ,Macklem PT

更新日期：2004-12-01 00:00:00

abstract：INTRODUCTION:Current concepts of the pathophysiology of acute pancreatitis suggest that disease progression from acinar injury to systemic illness involves a complex interplay between cellular and soluble inflammatory mediators and endothelial beds. To date, there is no specific pharmacologic intervention for acute pan...

journal_title：Critical care (London, England)

authors： Jamdar S,Siriwardena AK

更新日期：2005-08-01 00:00:00

abstract：INTRODUCTION:The endothelial specific angiopoietin (Ang)-Tie2 ligand-receptor system has been identified as a non-redundant mediator of endothelial activation in experimental sepsis. Binding of circulating Ang-1 to the Tie2 receptor protects the vasculature from inflammation and leakage, whereas binding of Ang-2 antago...

journal_title：Critical care (London, England)

authors： Kümpers P,Lukasz A,David S,Horn R,Hafer C,Faulhaber-Walter R,Fliser D,Haller H,Kielstein JT

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:To provide up-to-date information on the prognostic factors associated with 28-day mortality in a cohort of septic shock patients in intensive care units (ICUs). METHODS:Prospective, multicenter, observational cohort study in ICUs from 14 French general (non-academic) and university teaching hospitals. Al...

journal_title：Critical care (London, England)

authors： Quenot JP,Binquet C,Kara F,Martinet O,Ganster F,Navellou JC,Castelain V,Barraud D,Cousson J,Louis G,Perez P,Kuteifan K,Noirot A,Badie J,Mezher C,Lessire H,Pavon A

更新日期：2013-04-25 00:00:00

abstract：:Considerable progress has been made recently in the understanding of how best to accomplish safe and effective ventilation of patients with acute lung injury. Mechanical and nonmechanical factors contribute to causation of ventilator-associated lung injury. Intervention timing helps determine the therapeutic efficacy ...

journal_title：Critical care (London, England)

authors： Marini JJ

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:The present study examined the median survival, life expectancies, and cumulative incidence rate (CIR) of patients undergoing prolonged mechanical ventilation (PMV) stratified by different underlying diseases. METHODS:According to the National Health Insurance Research Database of Taiwan, there were 8,906...

journal_title：Critical care (London, England)

authors： Hung MC,Lu HM,Chen L,Hu FC,Chan SY,Yan YH,Fan PS,Lin MS,Chen CR,Kuo LC,Yu CJ,Wang JD

更新日期：2011-01-01 00:00:00

abstract：:The definition of what constitutes a 'normal' adrenal response to critical illness is unclear. Consequently, published studies have used a variety of biochemical criteria to define 'adrenal insufficiency'. These criteria have been based on the baseline cortisol level or the increment in cortisol following corticotropi...

journal_title：Critical care (London, England)

authors： Marik PE

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Severe sepsis is the leading cause of mortality in critically ill patients. Abnormal concentrations of inflammatory mediators appear to be involved in the pathogenesis of sepsis. Based on the humoral theory of sepsis, a potential therapeutic approach involves high-volume haemofiltration (HVHF), which has e...

journal_title：Critical care (London, England)

authors： Ratanarat R,Brendolan A,Piccinni P,Dan M,Salvatori G,Ricci Z,Ronco C

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:There are no easily available markers of renal recovery to guide intermittent hemodialysis (IHD) weaning. The aim of this study was to identify markers for IHD weaning in critically ill patients with acute kidney injury (AKI). METHODS:We performed a retrospective single-center cohort study of patients treat...

journal_title：Critical care (London, England)

authors： Aniort J,Ait Hssain A,Pereira B,Coupez E,Pioche PA,Leroy C,Heng AE,Souweine B,Lautrette A

更新日期：2016-02-19 00:00:00

abstract：INTRODUCTION:Fractalkine is a chemokine implicated as a mediator in a variety of inflammatory conditions. Knowledge of fractalkine release in patients presenting with infection to the Intensive Care Unit (ICU) is highly limited. The primary objective of this study was to establish whether plasma fractalkine levels are ...

journal_title：Critical care (London, England)

authors： Hoogendijk AJ,Wiewel MA,van Vught LA,Scicluna BP,Belkasim-Bohoudi H,Horn J,Zwinderman AH,Klein Klouwenberg PM,Cremer OL,Bonten MJ,Schultz MJ,van der Poll T,MARS consortium.

更新日期：2015-11-25 00:00:00

abstract：INTRODUCTION:A lack of data exists in the literature evaluating acidemia on admission as a favorable or negative prognostic factor in patients with acute cardiogenic pulmonary edema (ACPE) treated with non-invasive continuous positive airway pressure (CPAP). The objective of the present study was to investigate the imp...

journal_title：Critical care (London, England)

authors： Aliberti S,Piffer F,Brambilla AM,Bignamini AA,Rosti VD,Maraffi T,Monzani V,Cosentini R

更新日期：2010-01-01 00:00:00

abstract：:Type 2 diabetes has reached epidemic proportions in many parts of the world. The disease is projected to continue to increase and double within the foreseeable future. Dysglycaemia develops in the form of hyperglycaemia, hypoglycaemia and marked glucose variability in critically ill adults whether they are known to ha...

journal_title：Critical care (London, England)

authors： Smith FG,Sheehy AM,Vincent JL,Coursin DB

更新日期：2010-01-01 00:00:00

abstract：:A relative immunosuppression is observed in patients after sepsis, trauma, burns, or any severe insults. It is currently proposed that selected patients will benefit from treatment aimed at boosting their immune systems. However, the host immune response needs to be considered in context with pathogen-type, timing,and...

journal_title：Critical care (London, England)

authors： Cavaillon JM,Eisen D,Annane D

更新日期：2014-03-24 00:00:00

abstract：INTRODUCTION:Unawareness of an asymmetry between the right and left internal jugular vein (IJV) and methodological pitfalls in previous studies raise concerns about such asymmetry. Hence the aim of this prospective non-interventional study was to validate the hypothesis that right IJV diameter is greater than those of ...

journal_title：Critical care (London, England)

authors： Tartière D,Seguin P,Juhel C,Laviolle B,Mallédant Y

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Critical illness myopathy is an acquired skeletal muscle disorder with severe myosin loss and muscle weakness frequently seen in intensive care unit (ICU) patients. It is unknown if impaired excitation-contraction coupling contributes to the muscle weakness. METHODS:We used a unique ICU model where rats wer...

journal_title：Critical care (London, England)

authors： Llano-Diez M,Cheng AJ,Jonsson W,Ivarsson N,Westerblad H,Sun V,Cacciani N,Larsson L,Bruton J

更新日期：2016-08-10 00:00:00

abstract：INTRODUCTION:It has been unclear if mechanical cardiopulmonary resuscitation (CPR) is a viable alternative to manual CPR. We aimed to compare resuscitation outcomes before and after switching from manual CPR to load-distributing band (LDB) CPR in a multi-center emergency department (ED) trial. METHODS:We conducted a p...

journal_title：Critical care (London, England)

authors： Hock Ong ME,Fook-Chong S,Annathurai A,Ang SH,Tiah L,Yong KL,Koh ZX,Yap S,Sultana P

更新日期：2012-08-03 00:00:00

abstract：INTRODUCTION:Bacterial meningitis (BM) is a severe complication in patients with aneurysmal subarachnoid haemorrhage (SAH). Clinical signs of meningitis are often masked by SAH-related symptoms, and routine cerebrospinal fluid (CSF) analysis fails to indicate BM. Microdialysis (MD) is a technique for monitoring cerebra...

journal_title：Critical care (London, England)

authors： Schlenk F,Frieler K,Nagel A,Vajkoczy P,Sarrafzadeh AS

更新日期：2009-01-01 00:00:00

abstract：:Acute pancreatitis is an inflammatory disease process which may present with clinical manifestations ranging from benign self-limited disease to overwhelming sepsis. The ability to predict outcome would be helpful in developing treatment plans, and possibly in stratifying patients for clinical trials. ...

journal_title：Critical care (London, England)

authors： Rotstein OD

更新日期：2014-10-20 00:00:00

abstract：BACKGROUND:Hyperbilirubinaemia is a common occurrence in patients who are admitted to intensive care units (ICUs) after major surgery, and it is associated with high mortality. We investigated the incidence of hyperbilirubinaemia after two major types of thoracic surgery: open-heart surgery and oesophagectomy. In order...

journal_title：Critical care (London, England)

authors： Hosotsubo KK,Nishimura M,Nishimura S

更新日期：2000-01-01 00:00:00

abstract：:Drug acquisition costs are only a proportion of the total costs associated with drug therapy. The relevance of these costs are often not appreciated. However, they impact on the Intensive Care Unit via resources and quality of care. Increased indirect care by medical and nursing staff has the potential to adversely af...

journal_title：Critical care (London, England)

authors： Edbrooke DL,Bourne RS

更新日期：2003-12-01 00:00:00

abstract：INTRODUCTION:Staphylococcus (S.) aureus has emerged as an important cause of necrotizing pneumonia. Lung injury during S. aureus pneumonia may be enhanced by local release of damage associated molecular patterns such as high-mobility group box 1 (HMGB1). In the current study we sought to determine the functional role o...

journal_title：Critical care (London, England)

authors： Achouiti A,van der Meer AJ,Florquin S,Yang H,Tracey KJ,van 't Veer C,de Vos AF,van der Poll T

更新日期：2013-12-16 00:00:00

abstract：:Hemodynamic monitoring is a central component of intensive care. Patterns of hemodynamic variables often suggest cardiogenic, hypovolemic, obstructive, or distributive (septic) etiologies to cardiovascular insufficiency, thus defining the specific treatments required. Monitoring increases in invasiveness, as required,...

journal_title：Critical care (London, England)

authors： Pinsky MR,Payen D

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Prognostication in out-of-hospital cardiac arrest (OHCA) survivors is often difficult. Recent studies have shown the predictive ability of bispectral index (BIS) monitoring to assist with early neuroprognostication. The aim of this study was to investigate whether characteristics of BIS values equal to zero ...

journal_title：Critical care (London, England)

authors： Eertmans W,Genbrugge C,Haesevoets G,Dens J,Boer W,Jans F,De Deyne C

更新日期：2017-08-22 00:00:00

abstract：:Critical care medicine in China has made great advances in recent decades. This has led to an unavoidable issue: end-of-life ethics. With advances in medical technology and therapeutics allowing the seemingly limitless maintenance of life, the exact time of death of an individual patient is often determined by the dec...

journal_title：Critical care (London, England)

authors： Li LB

更新日期：2013-12-04 00:00:00

abstract：:Novel insights into the metabolic alterations of critical illness were published in Critical Care in 2009. The association between early hypoglycaemia/high glycemic variability and poor outcome was confirmed. Improvements in the understanding of the pathophysiological mechanisms of stress hyperglycemia and potential p...

journal_title：Critical care (London, England)

authors： Huberlant V,Preiser JC

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Inflammation may critically affect mechanisms of liver injury in acetaminophen (APAP) hepatotoxicity. Kupffer cells (KC) play important roles in inflammation, and KC depletion confers protection at early time points after APAP treatment but can lead to more severe injury at a later time point. It is possib...

journal_title：Critical care (London, England)

authors： Yang R,Zou X,Koskinen ML,Tenhunen J

更新日期：2012-01-16 00:00:00

abstract：INTRODUCTION:The goal of personalised medicine in the intensive care unit (ICU) is to predict which diagnostic tests, monitoring interventions and treatments translate to improved outcomes given the variation between patients. Unfortunately, processes such as gene transcription and drug metabolism are dynamic in the cr...

journal_title：Critical care (London, England)

authors： Celi LA,Hinske LC,Alterovitz G,Szolovits P

更新日期：2008-01-01 00:00:00