当前位置： SCI文献检索 > CRITICAL CARE期刊下所有文献 > Impaired Ca(2+) release contributes to muscle weakness in a rat model of critical illness myopathy.

Impaired Ca(2+) release contributes to muscle weakness in a rat model of critical illness myopathy.

Abstract：

BACKGROUND:Critical illness myopathy is an acquired skeletal muscle disorder with severe myosin loss and muscle weakness frequently seen in intensive care unit (ICU) patients. It is unknown if impaired excitation-contraction coupling contributes to the muscle weakness. METHODS:We used a unique ICU model where rats were deeply sedated, post-synaptically pharmacologically paralyzed, mechanically ventilated and closely monitored for up to ten days. Single intact fibers from the flexor digitorum brevis muscle were isolated and used to measure force and free myoplasmic [Ca(2+)] ([Ca(2+)]i) during tetanic contractions. RESULTS:Fibers from ICU rats had 80 % lower tetanic [Ca(2+)]i and produced only 15 % of the force seen in fibers from sham-operated (SHAM) rats. In the presence of 5 mM caffeine, tetanic [Ca(2+)]i was similar in fibers from ICU and SHAM rats but force was 50 % lower in fibers from ICU rats than SHAM rats. Confocal imaging showed disrupted tetanic [Ca(2+)]i transients in fibers from ICU rats compared to SHAM rats. Western blots showed similar levels of Na(+) channel and dihydropyridine receptor (DHPR) protein expression, whereas ryanodine receptor (RyR) and sarco-endoplasmic reticulum Ca(2+) ATPase 1 (SERCA1) expression was markedly lower in muscle of ICU rats than in SHAM rats. Immunohistochemical analysis showed that distribution of Na(+) channel and DHPR protein on the sarcolemma was disrupted in fibers from ICU rats compared with SHAM rats. CONCLUSIONS:These results suggest that impaired SR Ca(2+) release contributes to the muscle weakness seen in patients in ICU.

journal_name

Crit Care

journal_title

Critical care (London, England)

authors

Llano-Diez M,Cheng AJ,Jonsson W,Ivarsson N,Westerblad H,Sun V,Cacciani N,Larsson L,Bruton J

doi

10.1186/s13054-016-1417-z

subject

Has Abstract

pub_date

2016-08-10 00:00:00

pages

254

issue

1

eissn

1364-8535

issn

1466-609X

pii

10.1186/s13054-016-1417-z

journal_volume

20

pub_type

杂志文章

相关文献

CRITICAL CARE文献大全
  • Infections of respiratory or abdominal origin in ICU patients: what are the differences?

    abstract：INTRODUCTION:There are few data related to the effects of different sources of infection on outcome. We used the Sepsis Occurrence in Acutely ill Patients (SOAP) database to investigate differences in the impact of respiratory tract and abdominal sites of infection on organ failure and survival. METHODS:The SOAP study...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章,多中心研究

    doi：10.1186/cc8909

    authors： Volakli E,Spies C,Michalopoulos A,Groeneveld AB,Sakr Y,Vincent JL

    更新日期：2010-01-01 00:00:00

  • Impact of HIV/AIDS on care and outcomes of severe sepsis.

    abstract：INTRODUCTION:There has been dramatic improvement in survival for patients with HIV/AIDS; however, some studies on patients with HIV/AIDS and serious illness have reported continued low rates of intensive care. The purpose of this study was to examine patterns of care and outcomes for patients with severe sepsis and HIV...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章

    doi：10.1186/cc3811

    authors： Mrus JM,Braun L,Yi MS,Linde-Zwirble WT,Johnston JA

    更新日期：2005-01-01 00:00:00

  • Neurological manifestations of COVID-19: a systematic review.

    abstract：INTRODUCTION:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the global spread of coronavirus disease (COVID-19). Our understanding of the impact this virus has on the nervous system is limited. Our review aims to inform and improve decision-making among the physicians treating COVID-19 ...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章

    doi：10.1186/s13054-020-03121-z

    authors： Nepal G,Rehrig JH,Shrestha GS,Shing YK,Yadav JK,Ojha R,Pokhrel G,Tu ZL,Huang DY

    更新日期：2020-07-13 00:00:00

  • Brain dysfunction in sepsis: what can we learn from cerebral perfusion studies?

    abstract：:Investigations on the relationship between sepsis, brain dysfunction, and cerebral perfusion are methodologically very difficult to perform. It is important to interpret the results of such studies in view of our limited ability to diagnose and quantify brain dysfunction and to consider our limited understanding of th...

    journal_title：Critical care (London, England)

    pub_type： 评论,社论

    doi：10.1186/cc6217

    authors： Steiner LA

    更新日期：2008-01-01 00:00:00

  • Measuring the anticoagulant effect of low molecular weight heparins in the critically ill.

    abstract：:Antithrombotic prophylaxis in critically ill patients frequently fails. Venous thromboembolism is associated with adverse clinical outcomes, including a prolonged intensive care unit stay and death. A potential mechanism by which critically ill patients may be predisposed to antithrombotic failure is the inability to ...

    journal_title：Critical care (London, England)

    pub_type： 评论,杂志文章,评审

    doi：10.1186/cc4978

    authors： Crowther M,Lim W

    更新日期：2006-01-01 00:00:00

  • High-altitude physiology and pathophysiology: implications and relevance for intensive care medicine.

    abstract：:Cellular hypoxia is a fundamental mechanism of injury in the critically ill. The study of human responses to hypoxia occurring as a consequence of hypobaria defines the fields of high-altitude medicine and physiology. A new paradigm suggests that the physiological and pathophysiological responses to extreme environmen...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章,评审

    doi：10.1186/cc5142

    authors： Grocott M,Montgomery H,Vercueil A

    更新日期：2007-01-01 00:00:00

  • In vivo validation of the adequacy calculator for continuous renal replacement therapies.

    abstract：INTRODUCTION:The study was conducted to validate in vivo the Adequacy Calculator, a Microsoft Excel-based program, designed to assess the prescription and delivery of renal replacement therapy in the critical care setting. METHODS:The design was a prospective cohort study, set in two intensive care units of teaching h...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章,多中心研究

    doi：10.1186/cc3517

    authors： Ricci Z,Salvatori G,Bonello M,Pisitkun T,Bolgan I,D'Amico G,Dan M,Piccinni P,Ronco C

    更新日期：2005-06-01 00:00:00

  • Moderate hyperoxic versus near-physiological oxygen targets during and after coronary artery bypass surgery: a randomised controlled trial.

    abstract：BACKGROUND:The safety of perioperative hyperoxia is currently unclear. Previous studies in patients undergoing coronary artery bypass surgery suggest reduced myocardial damage when avoiding extreme perioperative hyperoxia (>400 mmHg). In this study we investigated whether an oxygenation strategy from moderate hyperoxia...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/s13054-016-1240-6

    authors： Smit B,Smulders YM,de Waard MC,Boer C,Vonk AB,Veerhoek D,Kamminga S,de Grooth HJ,García-Vallejo JJ,Musters RJ,Girbes AR,Oudemans-van Straaten HM,Spoelstra-de Man AM

    更新日期：2016-03-10 00:00:00

  • Long-term risk of sepsis among survivors of acute kidney injury.

    abstract：:Many prior studies have shown that, in critically ill patients, acute kidney injury (AKI) commonly occurs in association with sepsis and its presence portends an increased likelihood of poor outcomes. In contrast, few studies have focused specifically on the influence of AKI on the long-term risk of developing sepsis....

    journal_title：Critical care (London, England)

    pub_type： 评论,杂志文章

    doi：10.1186/cc13708

    authors： Clark E,Bagshaw SM

    更新日期：2014-01-24 00:00:00

  • Low B and T lymphocyte attenuator expression on CD4+ T cells in the early stage of sepsis is associated with the severity and mortality of septic patients: a prospective cohort study.

    abstract：INTRODUCTION:B and T lymphocyte attenuator (BTLA) is an inhibitory receptor, whose primary role in CD4(+) T cell is thought to inhibit cytokine production. We explore BTLA expression on CD4(+) T cells in healthy controls and septic patients, and assess the correlation of BTLA expression on CD4(+) T cells in the early s...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章

    doi：10.1186/s13054-015-1024-4

    authors： Shao R,Li CS,Fang Y,Zhao L,Hang C

    更新日期：2015-08-28 00:00:00

  • Artificial neural networks as prediction tools in the critically ill.

    abstract：:The past 25 years have witnessed the development of improved tools with which to predict short-term and long-term outcomes after critical illness. The general paradigm for constructing the best known tools has been the logistic regression model. Recently, a variety of alternative tools, such as artificial neural netwo...

    journal_title：Critical care (London, England)

    pub_type： 评论,杂志文章

    doi：10.1186/cc3507

    authors： Clermont G

    更新日期：2005-04-01 00:00:00

  • The subxiphoid view cannot replace the apical view for transthoracic echocardiographic assessment of hemodynamic status.

    abstract：INTRODUCTION:This prospective study aimed to assess whether use of the subxiphoid acoustic window in transthoracic echocardiography (TTE) can be an accurate alternative in the absence of an apical view to assess hemodynamic parameters. METHODS:This prospective study took place in a teaching hospital medical ICU. Over ...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章

    doi：10.1186/cc12869

    authors： Maizel J,Salhi A,Tribouilloy C,Massy ZA,Choukroun G,Slama M

    更新日期：2013-09-03 00:00:00

  • Granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) for sepsis: a meta-analysis.

    abstract：INTRODUCTION:To investigate the effects of G-CSF or GM-CSF therapy in non-neutropenic patients with sepsis. METHODS:A systematic literature search of Medline, Embase and Cochrane Central Register of Controlled Trials was conducted using specific search terms. A manual review of references was also performed. Eligible ...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章,meta分析,评审

    doi：10.1186/cc10031

    authors： Bo L,Wang F,Zhu J,Li J,Deng X

    更新日期：2011-01-01 00:00:00

  • Antiepileptic drugs in critically ill patients.

    abstract：BACKGROUND:The incidence of seizures in intensive care units ranges from 3.3% to 34%. It is therefore often necessary to initiate or continue anticonvulsant drugs in this setting. When a new anticonvulsant is initiated, drug factors, such as onset of action and side effects, and patient factors, such as age, renal, and...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章,评审

    doi：10.1186/s13054-018-2066-1

    authors： Farrokh S,Tahsili-Fahadan P,Ritzl EK,Lewin JJ 3rd,Mirski MA

    更新日期：2018-06-07 00:00:00

  • Clinical review: influenza pandemic - physicians and their obligations.

    abstract：:An influenza pandemic threatens to be the most lethal public health crisis to confront the world. Physicians will have critical roles in diagnosis, containment and treatment of influenza, and their commitment to treat despite increased personal risks is essential for a successful public health response. The obligation...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章,评审

    doi：10.1186/cc6918

    authors： Anantham D,McHugh W,O'Neill S,Forrow L

    更新日期：2008-01-01 00:00:00

  • Pulse contour analysis: is it able to reliably detect changes in cardiac output in the haemodynamically unstable patient?

    abstract：:Three pulse contour systems for monitoring cardiac output - LiDCO Plus™, PiCCO Plus™ and FloTrac™ - were compared in postcardiac surgery patients. None of the three methods demonstrated good trending ability according to concordance analysis. Pulse contour systems remain unreliable in the haemodynamically unstable pat...

    journal_title：Critical care (London, England)

    pub_type： 评论,杂志文章

    doi：10.1186/cc9381

    authors： Critchley LA

    更新日期：2011-01-19 00:00:00

  • Marked regional endothelial dysfunction in mottled skin area in patients with severe infections.

    abstract：BACKGROUND:Mottling around the knee, reflecting a reduced skin blood flow, is predictive of mortality in patients with septic shock. However, the causative pathophysiology of mottling remains unknown. We hypothesized that the cutaneous hypoperfusion observed in the mottled area is related to regional endothelial dysfun...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章

    doi：10.1186/s13054-017-1742-x

    authors： Bourcier S,Joffre J,Dubée V,Preda G,Baudel JL,Bigé N,Leblanc G,Levy BI,Guidet B,Maury E,Ait-Oufella H

    更新日期：2017-06-23 00:00:00

  • A pilot study of a new test to predict extubation failure.

    abstract：INTRODUCTION:To determine whether subjecting patients to 100 ml of additional dead space after a 120-minute weaning trial could predict readiness for extubation. METHODS:This was a prospective, non-randomised pilot study in an intensive care unit at a university hospital with 14 beds. It included all non-tracheostomis...

    journal_title：Critical care (London, England)

    pub_type： 临床试验,杂志文章

    doi：10.1186/cc7783

    authors： Solsona JF,Díaz Y,Vázquez A,Pilar Gracia M,Zapatero A,Marrugat J

    更新日期：2009-01-01 00:00:00

  • Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome.

    abstract：INTRODUCTION:Despite recent modifications, the clinical definition of the acute respiratory distress syndrome (ARDS) remains non-specific, leading to under-diagnosis and under-treatment. This study was designed to test the hypothesis that a biomarker panel would be useful for biologic confirmation of the clinical diagn...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章

    doi：10.1186/cc13080

    authors： Ware LB,Koyama T,Zhao Z,Janz DR,Wickersham N,Bernard GR,May AK,Calfee CS,Matthay MA

    更新日期：2013-10-24 00:00:00

  • Hypothalamo-pituitary-adrenal axis activity after intracranial catastrophies: what is enough?

    abstract：:This commentary on a paper by Bendel and colleagues in the previous issue of Critical Care describes the difficulty in assessing the sufficiency of adrenal responses to endogenous, stress-induced adrenocorticotropic hormone (ACTH) release by the pituitary or to exogenous ACTH administration in the critically ill patie...

    journal_title：Critical care (London, England)

    pub_type： 评论,杂志文章,评审

    doi：10.1186/cc7131

    authors： Groeneveld AB,Beishuizen A,Molenaar N

    更新日期：2009-01-01 00:00:00

  • Impact of transpulmonary thermodilution-based cardiac contractility and extravascular lung water measurements on clinical outcome of patients with Takotsubo cardiomyopathy after subarachnoid hemorrhage: a retrospective observational study.

    abstract：INTRODUCTION:Takotsubo cardiomyopathy (TCM) is a life-threatening systemic consequence early after subarachnoid hemorrhage (SAH), but precise hemodynamics and related outcome have not been studied. The purpose of this study was to investigate the TCM-induced cardiac function by transpulmonary thermodilution and its imp...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章

    doi：10.1186/s13054-014-0482-4

    authors： Mutoh T,Kazumata K,Terasaka S,Taki Y,Suzuki A,Ishikawa T

    更新日期：2014-08-12 00:00:00

  • The diagnosis of adrenal insufficiency in the critically ill patient: does it really matter?

    abstract：:The definition of what constitutes a 'normal' adrenal response to critical illness is unclear. Consequently, published studies have used a variety of biochemical criteria to define 'adrenal insufficiency'. These criteria have been based on the baseline cortisol level or the increment in cortisol following corticotropi...

    journal_title：Critical care (London, England)

    pub_type： 评论,杂志文章

    doi：10.1186/cc5105

    authors： Marik PE

    更新日期：2006-01-01 00:00:00

  • Life-threatening massive pulmonary embolism rescued by venoarterial-extracorporeal membrane oxygenation.

    abstract：BACKGROUND:Despite quick implementation of reperfusion therapies, a few patients with high-risk, acute, massive, pulmonary embolism (PE) remain highly hemodynamically unstable. Others have absolute contraindication to receive reperfusion therapies. Venoarterial-extracorporeal membrane oxygenation (VA-ECMO) might lower ...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章

    doi：10.1186/s13054-017-1655-8

    authors： Corsi F,Lebreton G,Bréchot N,Hekimian G,Nieszkowska A,Trouillet JL,Luyt CE,Leprince P,Chastre J,Combes A,Schmidt M

    更新日期：2017-03-28 00:00:00

  • Clinical review: Intensive care follow-up--what has it told us?

    abstract：:The majority of intensive care practitioners, until comparatively recently, was content to discharge surviving patients to the care of referring primary specialty colleagues who would undertake subsequent inpatient and outpatient care. With the exception of mortality statistics from clinical studies, the practitioners...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章,评审

    doi：10.1186/cc1532

    authors： Broomhead LR,Brett SJ

    更新日期：2002-10-01 00:00:00

  • The World Trade Center attack. Lessons for all aspects of health care.

    abstract：:The attack on the World Trade Center had the potential to overwhelm New York's health services. Sadly, however, the predicted thousands of treatable patients failed to materialize. Horror and sadness has now been replaced by anger, fear, and the determination to be better prepared next time. This determination not onl...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章,评审

    doi：10.1186/cc1053

    authors： Tamber PS,Vincent JL

    更新日期：2001-12-01 00:00:00

  • Novel insights in ICU-acquired respiratory muscle dysfunction: implications for clinical care.

    abstract：:This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2017. Other selected articles can be found online at http://ccforum.com/series/annualupdate2017 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章,评审

    doi：10.1186/s13054-017-1642-0

    authors： Jonkman AH,Jansen D,Heunks LM

    更新日期：2017-03-21 00:00:00

  • The Swiss bus accident on 13 March 2012: lessons for pre-hospital care.

    abstract：:The recent bus crash in Switzerland involving many children provides several lessons for the pre-hospital care community. The use of multiple helicopters that are capable of flying at night and that carry advanced medical pre-hospital teams undoubtedly saved lives following the tragedy. We describe the medical respons...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章

    doi：10.1186/cc11370

    authors： Lyon RM,Sanders J

    更新日期：2012-07-11 00:00:00

  • Left ventricular function: time-varying elastance and left ventricular aortic coupling.

    abstract：:Many aspects of left ventricular function are explained by considering ventricular pressure-volume characteristics. Contractility is best measured by the slope, Emax, of the end-systolic pressure-volume relationship. Ventricular systole is usefully characterized by a time-varying elastance (ΔP/ΔV). An extended area, t...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章,评审

    doi：10.1186/s13054-016-1439-6

    authors： Walley KR

    更新日期：2016-09-10 00:00:00

  • The epidemiology of septic shock in French intensive care units: the prospective multicenter cohort EPISS study.

    abstract：INTRODUCTION:To provide up-to-date information on the prognostic factors associated with 28-day mortality in a cohort of septic shock patients in intensive care units (ICUs). METHODS:Prospective, multicenter, observational cohort study in ICUs from 14 French general (non-academic) and university teaching hospitals. Al...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章,多中心研究

    doi：10.1186/cc12598

    authors： Quenot JP,Binquet C,Kara F,Martinet O,Ganster F,Navellou JC,Castelain V,Barraud D,Cousson J,Louis G,Perez P,Kuteifan K,Noirot A,Badie J,Mezher C,Lessire H,Pavon A

    更新日期：2013-04-25 00:00:00

  • Functional evaluation of sublingual microcirculation indicates successful weaning from VA-ECMO in cardiogenic shock.

    abstract：BACKGROUND:Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly adopted for the treatment of cardiogenic shock (CS). However, a marker of successful weaning remains largely unknown. Our hypothesis was that successful weaning is associated with sustained microcirculatory function during ECMO flow ...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章

    doi：10.1186/s13054-017-1855-2

    authors： Akin S,Dos Reis Miranda D,Caliskan K,Soliman OI,Guven G,Struijs A,van Thiel RJ,Jewbali LS,Lima A,Gommers D,Zijlstra F,Ince C

    更新日期：2017-10-26 00:00:00