Abstract:
:With imprecise definitions, inexact measurement tools, and flawed study execution, our clinical science often lags behind bedside experience and simply documents what appear to be the apparent faults or validity of ongoing practices. These impressions are later confirmed, modified, or overturned by the results of the next trial. On the other hand, insights that stem from the intuitions of experienced clinicians, scientists and educators-while often neglected-help place current thinking into proper perspective and occasionally point the way toward formulating novel hypotheses that direct future research. Both streams of information and opinion contribute to progress. In this paper we present a wide-ranging set of unproven 'out of the mainstream' ideas of our FCCM faculty, each with a defensible rationale and holding clear implications for altering bedside management. Each proposition was designed deliberately to be provocative so as to raise awareness, stimulate new thinking and initiate lively dialog.
journal_name
Crit Carejournal_title
Critical care (London, England)authors
Marini JJ,De Backer D,Ince C,Singer M,Van Haren F,Westphal M,Wischmeyer Pdoi
10.1186/s13054-017-1904-xsubject
Has Abstractpub_date
2017-12-28 00:00:00pages
315issue
Suppl 3eissn
1364-8535issn
1466-609Xpii
10.1186/s13054-017-1904-xjournal_volume
21pub_type
杂志文章,评审相关文献
CRITICAL CARE文献大全abstract:BACKGROUND:Omega-3 (ω-3) fatty acid (FA)-containing parenteral nutrition (PN) is associated with significant improvements in patient outcomes compared with standard PN regimens without ω-3 FA lipid emulsions. Here, we evaluate the impact of ω-3 FA-containing PN versus standard PN on clinical outcomes and costs in adult...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03356-w
更新日期:2020-11-03 00:00:00
abstract:INTRODUCTION:Tight glucose control therapy (TGC) has been implemented to control hyperglycemia in ICU patients. TGC may also influence serum potassium concentrations. We therefore investigated the influence of TGC on both serum glucose and serum potassium concentrations and associated mortality. METHOD:We performed a ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-015-0959-9
更新日期:2015-06-22 00:00:00
abstract:INTRODUCTION:In critically ill patients, delirium is a serious and frequent disorder that is associated with a prolonged intensive care and hospital stay and an increased morbidity and mortality. Without the use of a delirium screening instrument, delirium is often missed by ICU nurses and physicians. The effects of im...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7991
更新日期:2009-01-01 00:00:00
abstract::Acid-base abnormalities are common in critically ill patients. Our ability to describe acid-base disorders must be precise. Small differences in corrections for anion gap, different types of analytical processes, and the basic approach used to diagnose acid-base aberrations can lead to markedly different interpretatio...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc3796
更新日期:2005-10-05 00:00:00
abstract::Primary or secondary infection of necrotized areas by enteral bacteria is considered a primary cause of mortality in patients with severe acute pancreatitis (SAP). Indeed, 20-30% of patients die during the course of the disease from multiple organ dysfunction after infection. This is why strategies such as antibiotic ...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc3007
更新日期:2004-12-01 00:00:00
abstract::Critical care medicine in China has made great advances in recent decades. This has led to an unavoidable issue: end-of-life ethics. With advances in medical technology and therapeutics allowing the seemingly limitless maintenance of life, the exact time of death of an individual patient is often determined by the dec...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc13140
更新日期:2013-12-04 00:00:00
abstract::Several papers are discussed including the CARP (Coronary Artery Revascularisation Prophylaxis) trial, examining the role, if any, of preoperative coronary revascularisation and a study examining the heart rate in the intensive care unit (ICU) population. We also take a look at infections in the ICU with particular re...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc3505
更新日期:2005-04-01 00:00:00
abstract:INTRODUCTION:Some types of antimicrobial-coated central venous catheters (A-CVC) have been shown to be cost effective in preventing catheter-related bloodstream infection (CR-BSI). However, not all types have been evaluated, and there are concerns over the quality and usefulness of these earlier studies. There is uncer...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7744
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Functional status (FS) before intensive care unit (ICU) admission is associated with short-term and long-term outcomes among critically ill patients. However, measures of FS are generally not integrated into ICU-specific mortality prediction models. METHODS:This retrospective cohort study used prospectively...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-017-1688-z
更新日期:2017-05-15 00:00:00
abstract:PURPOSE:Measurement of central venous pressure (CVP) can be a useful clinical tool. However, the formal utility of CVP measurement in preventing mortality in septic patients has never been proven. METHODS:The Medical Information Mart for Intensive Care III (MIMIC-III) database was searched to identify septic patients ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03109-9
更新日期:2020-07-14 00:00:00
abstract:INTRODUCTION:Bacterial infection represents a serious risk in neonates and critically ill paediatric patients. Current clinical practice is characterized by frequent antibiotic treatment despite low incidence of true infection. However, some patients escape early diagnosis and progress to septic shock. Many new markers...
journal_title:Critical care (London, England)
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1186/cc2971
更新日期:2004-12-01 00:00:00
abstract::Hemodynamic monitoring is a central component of intensive care. Patterns of hemodynamic variables often suggest cardiogenic, hypovolemic, obstructive, or distributive (septic) etiologies to cardiovascular insufficiency, thus defining the specific treatments required. Monitoring increases in invasiveness, as required,...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc3927
更新日期:2005-01-01 00:00:00
abstract::The rapid response system concept is one of the first patient-centered and organizational-wide systems aimed at preventing deaths and serious adverse events. It has been strongly argued that we need a benchmark that reflects the care of a deteriorating patient across the organization using a 'score to door time'; that...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc10477
更新日期:2011-01-01 00:00:00
abstract::The European Clinical Trials Directive requires an informed consent from the patient or a proxy in drug trials. Although informed consent is a valuable tool to protect patients' rights in clinical trials, this requirement largely impedes research in critical care settings, and if pursued in this context, it does not p...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc10113
更新日期:2011-01-01 00:00:00
abstract::Experiencing treatment on a modern intensive care unit (ICU) is a potentially traumatic event. People who experience traumatic events have an increased risk of depression, anxiety disorders and post-traumatic stress disorder (PTSD). Extended follow-up has confirmed that many patients suffer physical and psychological ...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc10054
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Lowering of hyperglycemia in the intensive care unit (ICU) is widely practiced. We investigated in which way glucose regulation, defined as mean glucose concentration during admission, is associated with ICU mortality in a medical and a surgical cohort. METHODS:Retrospective database cohort study includin...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc9369
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Survivors of an acute critical illness with continuing organ dysfunction and uncontrolled inflammatory responses are prone to become chronically critically ill. As mental sequelae, a post-traumatic stress disorder and an associated decrease in the health-related quality of life (QoL) may occur, not only in t...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-019-2321-0
更新日期:2019-02-08 00:00:00
abstract::Severe burn injury remains a major burden on patients and healthcare systems. Following severe burns, the injured tissues mount a local inflammatory response aiming to restore homeostasis. With excessive burn load, the immune response becomes disproportionate and patients may develop an overshooting systemic inflammat...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc7794
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:The overall prognosis of critically ill patients with cancer has improved during the past decade. The aim of this study was to identify early prognostic factors of intensive care unit (ICU) mortality in patients with cancer. METHODS:We designed a prospective, consecutive, observational study over a one-ye...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc5721
更新日期:2007-01-01 00:00:00
abstract::Postoperative outcome is mainly influenced by ventricular function. Tests designed to identify myocardial ischemia alone will fail to detect cardiac failure and are thus inadequate as a screening test for identification of cardiac risk in noncardiac surgical patients. We find that the degree of cardiac failure is the ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc2848
更新日期:2004-10-01 00:00:00
abstract:INTRODUCTION:Expanding the criteria for deceased organ donors increases the risk of delayed graft function (DGF) and complicates kidney transplant outcome. We studied whether donor neutrophil gelatinase-associated lipocalin (NGAL), a novel biomarker for acute kidney injury, could predict DGF after transplantation. MET...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc10220
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Septic shock (SS) and cardiogenic shock (CS) are two types of circulatory shock with a different etiology. Several studies have described the molecular alterations in SS patients, whereas the molecular factors involved in CS have been poorly investigated. We aimed to assess in the whole blood of CS and SS pa...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/s13054-019-2670-8
更新日期:2019-12-19 00:00:00
abstract:INTRODUCTION:Inflammation and coagulation are closely linked, and both can be triggered by endotoxin. Thrombelastometry and impedance aggregometry are of diagnostic and predictive value in critically ill patients. In this observational study we investigated the correlation of endotoxin activity with thrombelasometric a...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc12892
更新日期:2013-09-11 00:00:00
abstract:BACKGROUND:Several biological markers of lung injury are predictors of morbidity and mortality in patients with acute lung injury (ALI). The low tidal volume lung-protective ventilation strategy is associated with a significant decrease in plasma biomarker levels compared to the high tidal volume ventilation strategy. ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc5037
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:The lack of a patent source of infection after 24 hours of management of shock considered septic is a common and disturbing scenario. We aimed to determine the prevalence and the causes of shock with no diagnosis 24 hours after its onset, and to compare the outcomes of patients with early-confirmed septic sh...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/s13054-016-1537-5
更新日期:2016-11-06 00:00:00
abstract:INTRODUCTION:Delirium occurs in most ventilated patients and is independently associated with more deaths, longer stay, and higher cost. Guidelines recommend monitoring of delirium in all intensive care unit (ICU) patients, though few data exist in non-ventilated patients. The study objective was to determine the relat...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc3729
更新日期:2005-08-01 00:00:00
abstract::Progress in management of critically ill neurological patients has led to improved survival rates. However, severe residual neurological impairment, such as persistent coma, occurs in some survivors. This raises concerns about whether it is ethically appropriate to apply aggressive care routinely, which is also associ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc6107
更新日期:2007-01-01 00:00:00
abstract::Bacterial pathogens possess an array of specific mechanisms that confer virulence and the capacity to avoid host defence mechanisms. Mechanisms of virulence are often mediated by the subversion of normal aspects of host biology. In this way the pathogen modifies host function so as to promote the pathogen's survival o...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc7091
更新日期:2008-01-01 00:00:00
abstract::COVID-19 has caused great devastation in the past year. Multi-organ point-of-care ultrasound (PoCUS) including lung ultrasound (LUS) and focused cardiac ultrasound (FoCUS) as a clinical adjunct has played a significant role in triaging, diagnosis and medical management of COVID-19 patients. The expert panel from 27 co...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-020-03369-5
更新日期:2020-12-24 00:00:00
abstract:OBJECTIVES:To evaluate the resuscitative effects of mechanical and manual chest compression in patients with out-of-hospital cardiac arrest (OHCA). METHODS:All randomized controlled and cohort studies comparing the effects of mechanical compression and manual compression on cardiopulmonary resuscitation in OHCA patien...
journal_title:Critical care (London, England)
pub_type: 杂志文章,meta分析
doi:10.1186/s13054-019-2389-6
更新日期:2019-03-27 00:00:00