Rapid response systems: you won't know there is a problem until you measure it.

abstract：:The early detection and treatment of sepsis are the most important factors in improving the outcome of patients with this condition. However, many patients admitted to hospital experience a long delay in the diagnosis of sepsis. Furthermore, it is not uncommon for febrile patients to be sent home from the Emergency De...

journal_title：Critical care (London, England)

authors： Marik PE

更新日期：2014-09-27 00:00:00

abstract：:Sepsis, despite recent therapeutic progress, still carries unacceptably high mortality rates. The adrenergic system, a key modulator of organ function and cardiovascular homeostasis, could be an interesting new therapeutic target for septic shock. Beta-adrenergic regulation of the immune function in sepsis is complex ...

journal_title：Critical care (London, England)

authors： de Montmollin E,Aboab J,Mansart A,Annane D

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The dysregulated host immune response that defines sepsis varies as a function of both the immune status of the host and the distinct nature of the pathogen. The degree to which immunocompromising comorbidities or immunosuppressive medications affect the immune response to infection is poorly understood beca...

journal_title：Critical care (London, England)

authors： Greenberg JA,Hrusch CL,Jaffery MR,David MZ,Daum RS,Hall JB,Kress JP,Sperling AI,Verhoef PA

更新日期：2018-04-25 00:00:00

abstract：INTRODUCTION:Early multimodal treatment of severe sepsis, including the use of drotrecogin alfa (activated) (DrotAA) when indicated, is considered essential for optimum outcome. However, predicting which infected patients will progress to severe sepsis and the need for aggressive intervention continues to be problemati...

journal_title：Critical care (London, England)

authors： Hodder RV,Hall R,Russell JA,Fisher HN,Lee B

更新日期：2009-01-01 00:00:00

abstract：:Over the last years, there was an increase in the number and severity of Clostridium difficile infections (CDI) in all medical settings, including the intensive care unit (ICU). The current prevalence of CDI among ICU patients is estimated at 0.4-4% and has severe impact on morbidity and mortality. An estimated 10-20%...

journal_title：Critical care (London, England)

authors： Prechter F,Katzer K,Bauer M,Stallmach A

更新日期：2017-10-22 00:00:00

abstract：INTRODUCTION:Pulmonary embolism (PE) is one of the greatest diagnostic challenges in prehospital emergency setting. Most patients with suspected PE have a positive D-dimer and undergo diagnostic testing. Excluding PE with additional non-invasive tests would reduce the need for further imaging tests. We aimed to determi...

journal_title：Critical care (London, England)

authors： Rumpf TH,Krizmaric M,Grmec S

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:The frequency and clinical significance of polymicrobial aetiology in community-acquired pneumonia (CAP) patients admitted to the ICU have been poorly studied. The aim of the present study was to describe the prevalence, clinical characteristics and outcomes of severe CAP of polymicrobial aetiology in pati...

journal_title：Critical care (London, England)

authors： Cillóniz C,Ewig S,Ferrer M,Polverino E,Gabarrús A,Puig de la Bellacasa J,Mensa J,Torres A

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Economic evaluations of interventions in the hospital setting often rely on the estimated long-term impact on patient survival. Estimates of mortality rates and long-term outcomes among patients discharged alive from the intensive care unit (ICU) are lacking from lower- and middle-income countries. This st...

journal_title：Critical care (London, England)

authors： Luangasanatip N,Hongsuwan M,Lubell Y,Limmathurotsakul D,Teparrukkul P,Chaowarat S,Day NP,Graves N,Cooper BS

更新日期：2013-10-03 00:00:00

abstract：INTRODUCTION:Continuous renal replacement therapy (CRRT) has been widely used in critically ill acute kidney injury (AKI) patients. Moreover, some centers operate a specialized CRRT team (SCT) composed of physicians and nurses, but few studies have yet determined the superiority of SCT control. METHODS:A total of 334 ...

journal_title：Critical care (London, England)

authors： Oh HJ,Lee MJ,Kim CH,Kim DY,Lee HS,Park JT,Na S,Han SH,Kang SW,Koh SO,Yoo TH

更新日期：2014-08-13 00:00:00

abstract：:Postoperative outcome is mainly influenced by ventricular function. Tests designed to identify myocardial ischemia alone will fail to detect cardiac failure and are thus inadequate as a screening test for identification of cardiac risk in noncardiac surgical patients. We find that the degree of cardiac failure is the ...

journal_title：Critical care (London, England)

authors： Older P,Hall A

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Heterogeneity of acute respiratory distress syndrome (ARDS) could be reduced by identification of biomarker-based phenotypes. The set of ARDS biomarkers to prospectively define these phenotypes remains to be established. OBJECTIVE:To provide an overview of the biomarkers that were multivariately associated ...

journal_title：Critical care (London, England)

authors： van der Zee P,Rietdijk W,Somhorst P,Endeman H,Gommers D

更新日期：2020-05-24 00:00:00

abstract：BACKGROUND:This study aimed to investigate the feasibility of optical coherence tomography angiography (OCT-A) for quantitative analysis of flow density to assess changes in retinal perfusion in an experimental model of haemorrhagic shock. METHODS:Haemorrhagic shock was induced in five healthy, anaesthetized sheep by ...

journal_title：Critical care (London, England)

authors： Alnawaiseh M,Ertmer C,Seidel L,Arnemann PH,Lahme L,Kampmeier TG,Rehberg SW,Heiduschka P,Eter N,Hessler M

更新日期：2018-05-29 00:00:00

abstract：:Providing effective analgesia and adequate sedation is a generally accepted goal of intensive care medicine. Due to its rapid, organ independent and predictable metabolism the short acting opioid remifentanil might be particularly useful for analgesia-based sedation in the intensive care unit (ICU). This hypothesis wa...

journal_title：Critical care (London, England)

authors： Kuhlen R,Putensen C

更新日期：2004-02-01 00:00:00

abstract：INTRODUCTION:Epidemiologic assessment of critically ill people in Intensive Care Units (ICUs) is needed to ensure the health care system can meet current and future needs. However, few such studies have been published. METHODS:Population-based analysis of all adult ICU care in the Canadian province of Manitoba, 1999 t...

journal_title：Critical care (London, England)

authors： Garland A,Olafson K,Ramsey CD,Yogendran M,Fransoo R

更新日期：2013-09-30 00:00:00

abstract：:The European Society of Intensive Care Medicine Annual Congress offers the opportunity for basic scientists and clinicians to share recent findings. Apart from the large number of free communications, several sessions of the congress were dedicated to state-of-the-art tutorials given by established speakers. The areas...

journal_title：Critical care (London, England)

authors： Preiser JC

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Expert systems can help alleviate problems related to the shortage of human resources in critical care, offering expert advice in complex situations. Expert systems use contextual information to provide advice to staff. In mechanical ventilation, it is crucial for an expert system to be able to determine the...

journal_title：Critical care (London, England)

authors： Murias G,Montanyà J,Chacón E,Estruga A,Subirà C,Fernández R,Sales B,de Haro C,López-Aguilar J,Lucangelo U,Villar J,Kacmarek RM,Blanch L

更新日期：2016-08-14 00:00:00

abstract：INTRODUCTION:There has been dramatic improvement in survival for patients with HIV/AIDS; however, some studies on patients with HIV/AIDS and serious illness have reported continued low rates of intensive care. The purpose of this study was to examine patterns of care and outcomes for patients with severe sepsis and HIV...

journal_title：Critical care (London, England)

authors： Mrus JM,Braun L,Yi MS,Linde-Zwirble WT,Johnston JA

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:A lack of data exists in the literature evaluating acidemia on admission as a favorable or negative prognostic factor in patients with acute cardiogenic pulmonary edema (ACPE) treated with non-invasive continuous positive airway pressure (CPAP). The objective of the present study was to investigate the imp...

journal_title：Critical care (London, England)

authors： Aliberti S,Piffer F,Brambilla AM,Bignamini AA,Rosti VD,Maraffi T,Monzani V,Cosentini R

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Inhaled nitric oxide (iNO) is a rescue therapy for severe hypoxemia in patients with acute respiratory distress syndrome (ARDS). Pooled data from clinical trials have signaled a renal safety warning for iNO therapy, but the significance of these findings in daily clinical practice is unclear. We used primary...

journal_title：Critical care (London, England)

authors： Ruan SY,Wu HY,Lin HH,Wu HD,Yu CJ,Lai MS

更新日期：2016-11-30 00:00:00

abstract：:Relatively simple measures of echocardiography and Doppler, as left ventricular end-systolic area and volume, should be taken in consideration when performing a Doppler echocardiographic examination, as they could have both clinical and prognostic value. ...

journal_title：Critical care (London, England)

authors： Poelaert J,Roosens C

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:The present study examined the median survival, life expectancies, and cumulative incidence rate (CIR) of patients undergoing prolonged mechanical ventilation (PMV) stratified by different underlying diseases. METHODS:According to the National Health Insurance Research Database of Taiwan, there were 8,906...

journal_title：Critical care (London, England)

authors： Hung MC,Lu HM,Chen L,Hu FC,Chan SY,Yan YH,Fan PS,Lin MS,Chen CR,Kuo LC,Yu CJ,Wang JD

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Electrical impedance tomography (EIT) is a non-invasive bedside tool which allows an individualized ventilator strategy by monitoring tidal ventilation and lung aeration. EIT can be performed at different cranio-caudal thoracic levels, but data are missing about the optimal belt position. The main goal of th...

journal_title：Critical care (London, England)

authors： Karsten J,Stueber T,Voigt N,Teschner E,Heinze H

更新日期：2016-01-08 00:00:00

abstract：:Diagnosis of sepsis is complicated by non-specific clinical definitions and delays in laboratory analysis using tests which may have very poor predictive values. The use of host biomarker signature sets, which when measured in combination have high predictive values, offers a paradigm shift forwards for rapid, near-pa...

journal_title：Critical care (London, England)

authors： Silman NJ

更新日期：2013-12-04 00:00:00

abstract：INTRODUCTION:Succinylcholine and rocuronium are widely used to facilitate rapid sequence induction (RSI) intubation in intensive care. Concerns relate to the side effects of succinylcholine and to slower onset and inferior intubation conditions associated with rocuronium. So far, succinylcholine and rocuronium have not...

journal_title：Critical care (London, England)

authors： Marsch SC,Steiner L,Bucher E,Pargger H,Schumann M,Aebi T,Hunziker PR,Siegemund M

更新日期：2011-08-16 00:00:00

abstract：:The optimal length of antimicrobial therapy has not been extensively studied for a great majority of infections and, in critically ill patients affected by ventilator-associated pneumonia, is a persisting and unsolved issue confronting clinicians. The integration of biomarkers, clinical judgment, and microbiologic era...

journal_title：Critical care (London, England)

authors： Martin-Loeches I,Torres A

更新日期：2013-01-21 00:00:00

abstract：INTRODUCTION:The objective was to study the effects of a novel lung volume optimization procedure (LVOP) using high-frequency oscillatory ventilation (HFOV) upon gas exchange, the transpulmonary pressure (TPP), and hemodynamics in a porcine model of surfactant depletion. METHODS:With institutional review board approva...

journal_title：Critical care (London, England)

authors： Karmrodt J,David M,Yuan S,Markstaller K

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:The early aggressive management of the acute coagulopathy of trauma may improve survival in the trauma population. However, the timely identification of lethal exsanguination remains challenging. This study validated six scoring systems and algorithms to stratify patients for the risk of massive transfusio...

journal_title：Critical care (London, England)

authors： Brockamp T,Nienaber U,Mutschler M,Wafaisade A,Peiniger S,Lefering R,Bouillon B,Maegele M,TraumaRegister DGU.

更新日期：2012-07-20 00:00:00

abstract：:Determine the effectiveness of decontamination, and perform thorough dry or wet decontamination, depending on the circumstances. Always remain cognizant of the fact that, even after decontamination has been completed, contamination may not have been completely eliminated. Perform periodic monitoring to determine wheth...

journal_title：Critical care (London, England)

authors： Okumura S,Okumura T,Ishimatsu S,Miura K,Maekawa H,Naito T

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Bloodstream infections are associated with high morbidity and mortality, both of which contribute substantially to healthcare costs. The effects of early administration of appropriate antimicrobials on the prognosis and timing of defervescence of bacteremic patients remain under debate. METHODS:In a 6-year ...

journal_title：Critical care (London, England)

authors： Lee CC,Lee CH,Yang CY,Hsieh CC,Tang HJ,Ko WC

更新日期：2019-11-20 00:00:00

abstract：:Acute pancreatitis is an inflammatory disease process which may present with clinical manifestations ranging from benign self-limited disease to overwhelming sepsis. The ability to predict outcome would be helpful in developing treatment plans, and possibly in stratifying patients for clinical trials. ...

journal_title：Critical care (London, England)

authors： Rotstein OD

更新日期：2014-10-20 00:00:00