Bench-to-bedside review: potential strategies to protect or reverse mitochondrial dysfunction in sepsis-induced organ failure.

abstract：BACKGROUND:Heterogeneity of acute respiratory distress syndrome (ARDS) could be reduced by identification of biomarker-based phenotypes. The set of ARDS biomarkers to prospectively define these phenotypes remains to be established. OBJECTIVE:To provide an overview of the biomarkers that were multivariately associated ...

journal_title：Critical care (London, England)

authors： van der Zee P,Rietdijk W,Somhorst P,Endeman H,Gommers D

更新日期：2020-05-24 00:00:00

abstract：:Barriers to the use of selective digestive decontamination include concerns about emergence of resistant organisms, over-estimation of current performance in preventing ventilator-associated pneumonia (VAP), alternative methods of preventing VAP, and misunderstanding of mechanisms of action. A definitive cluster-rando...

journal_title：Critical care (London, England)

authors： Bion J

更新日期：2013-12-19 00:00:00

abstract：INTRODUCTION:Protocols using high levels of positive end-expiratory pressure (PEEP) in combination with low tidal volumes have been shown to reduce mortality in patients with severe acute respiratory distress syndrome (ARDS). However, the optimal method for setting PEEP is yet to be defined. It has been shown that resp...

journal_title：Critical care (London, England)

authors： Kostic P,Zannin E,Andersson Olerud M,Pompilio PP,Hedenstierna G,Pedotti A,Larsson A,Frykholm P,Dellaca RL

更新日期：2011-01-01 00:00:00

abstract：:This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2017. Other selected articles can be found online at http://ccforum.com/series/annualupdate2017 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www...

journal_title：Critical care (London, England)

authors： Tagami T,Yasunaga H,Yokota H

更新日期：2017-03-21 00:00:00

abstract：BACKGROUND:Post-resuscitation hemodynamic instability following out-of-hospital cardiac arrest (OHCA) may occur from myocardial dysfunction underlying cardiogenic shock and/or inflammation-mediated distributive shock. Distinguishing the predominant shock subtype with widely available clinical metrics may have prognosti...

journal_title：Critical care (London, England)

authors： Anderson RJ,Jinadasa SP,Hsu L,Ghafouri TB,Tyagi S,Joshua J,Mueller A,Talmor D,Sell RE,Beitler JR

更新日期：2018-06-15 00:00:00

abstract：BACKGROUND:Intensive care units (ICUs) face financial, bed management, and staffing constraints. Detailed data covering all aspects of patients' journeys into and through intensive care are now collected and stored in electronic health records: machine learning has been used to analyse such data in order to provide dec...

journal_title：Critical care (London, England)

authors： Shillan D,Sterne JAC,Champneys A,Gibbison B

更新日期：2019-08-22 00:00:00

abstract：:Emergency departments (EDs) face several challenges in maintaining consistent quality care in the face of steadily increasing public demand. Improvements in the survival rate of critically ill patients in the ED are directly related to the advancement of early recognition and treatment. Frequent episodes of overcrowdi...

journal_title：Critical care (London, England)

authors： Rooney KD,Schilling UM

更新日期：2014-12-08 00:00:00

abstract：:Certain noble gases, though inert, exhibit remarkable biological properties. Notably, xenon and argon provide neuroprotection in animal models of central nervous system injury. In the previous issue of Critical Care, Loetscher and colleagues provided further evidence that argon may have therapeutic properties for neur...

journal_title：Critical care (London, England)

authors： Sanders RD,Ma D,Maze M

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Recent data have suggested that patient admission during intensive care unit (ICU) morning bedside rounds is associated with less favorable outcome. We undertook the present study to explore the association between morning round-time ICU admissions and hospital mortality in a large Canadian health region. ...

journal_title：Critical care (London, England)

authors： de Souza IA,Karvellas CJ,Gibney RT,Bagshaw SM

更新日期：2012-05-03 00:00:00

abstract：:A relative immunosuppression is observed in patients after sepsis, trauma, burns, or any severe insults. It is currently proposed that selected patients will benefit from treatment aimed at boosting their immune systems. However, the host immune response needs to be considered in context with pathogen-type, timing,and...

journal_title：Critical care (London, England)

authors： Cavaillon JM,Eisen D,Annane D

更新日期：2014-03-24 00:00:00

abstract：INTRODUCTION:Functional assessment of arterial load by dynamic arterial elastance (Eadyn), defined as the ratio between pulse pressure variation (PPV) and stroke volume variation (SVV), has recently been shown to predict the arterial pressure response to volume expansion (VE) in hypotensive, preload-dependent patients....

journal_title：Critical care (London, England)

authors： García MI,Romero MG,Cano AG,Aya HD,Rhodes A,Grounds RM,Cecconi M

更新日期：2014-11-19 00:00:00

abstract：INTRODUCTION:Protocols for the delivery of analgesia, sedation and delirium care of the critically ill, mechanically ventilated patient have been shown to improve outcomes but are not uniformly used. The extent to which elements of analgesia, sedation and delirium guidelines are incorporated into order sets at hospital...

journal_title：Critical care (London, England)

authors： Dale CR,Hayden SJ,Treggiari MM,Curtis JR,Seymour CW,Yanez ND 3rd,Fan VS

更新日期：2012-06-18 00:00:00

abstract：OBJECTIVES:To evaluate the resuscitative effects of mechanical and manual chest compression in patients with out-of-hospital cardiac arrest (OHCA). METHODS:All randomized controlled and cohort studies comparing the effects of mechanical compression and manual compression on cardiopulmonary resuscitation in OHCA patien...

journal_title：Critical care (London, England)

authors： Zhu N,Chen Q,Jiang Z,Liao F,Kou B,Tang H,Zhou M

更新日期：2019-03-27 00:00:00

abstract：INTRODUCTION:Pulmonary embolism (PE) is one of the greatest diagnostic challenges in prehospital emergency setting. Most patients with suspected PE have a positive D-dimer and undergo diagnostic testing. Excluding PE with additional non-invasive tests would reduce the need for further imaging tests. We aimed to determi...

journal_title：Critical care (London, England)

authors： Rumpf TH,Krizmaric M,Grmec S

更新日期：2009-01-01 00:00:00

abstract：:Severe sepsis can be a catastrophic condition that is often associated with poor outcomes. The early diagnosis and management of the condition are vital in order to improve the chances of survival. However, owing to the syndromal nature of its definition and the lack of a biomarker able to accurately confirm the condi...

journal_title：Critical care (London, England)

authors： Rhodes A,Cecconi M

更新日期：2012-11-08 00:00:00

abstract：INTRODUCTION:Lung protective ventilation requires low tidal volume and suitable positive end-expiratory pressure (PEEP). To date, few methods have been accepted for clinical use to set the appropriate PEEP. The aim of this study was to test the feasibility of PEEP titration guided by ventilation homogeneity using the g...

journal_title：Critical care (London, England)

authors： Zhao Z,Steinmann D,Frerichs I,Guttmann J,Möller K

更新日期：2010-01-01 00:00:00

abstract：:The attack on the World Trade Center had the potential to overwhelm New York's health services. Sadly, however, the predicted thousands of treatable patients failed to materialize. Horror and sadness has now been replaced by anger, fear, and the determination to be better prepared next time. This determination not onl...

journal_title：Critical care (London, England)

authors： Tamber PS,Vincent JL

更新日期：2001-12-01 00:00:00

abstract：INTRODUCTION:Acute kidney injury (AKI) is a frequent complication after cardiac surgery with cardiopulmonary bypass in infants. Renal near-infrared spectroscopy (NIRS) is used to evaluate regional oximetry in a non-invasive continuous real-time fashion, and reflects tissue perfusion. The aim of this study was to evalua...

journal_title：Critical care (London, England)

authors： Ruf B,Bonelli V,Balling G,Hörer J,Nagdyman N,Braun SL,Ewert P,Reiter K

更新日期：2015-01-29 00:00:00

abstract：INTRODUCTION:In transgenic animal models of sepsis, members of the Bcl-2 family of proteins regulate lymphocyte apoptosis and survival of sepsis. This study investigates the gene regulation of pro-apoptotic and anti-apoptotic members of the Bcl-2 family of proteins in patients with early stage severe sepsis. METHODS:I...

journal_title：Critical care (London, England)

authors： Weber SU,Schewe JC,Lehmann LE,Müller S,Book M,Klaschik S,Hoeft A,Stüber F

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:There are few data related to the effects of different sources of infection on outcome. We used the Sepsis Occurrence in Acutely ill Patients (SOAP) database to investigate differences in the impact of respiratory tract and abdominal sites of infection on organ failure and survival. METHODS:The SOAP study...

journal_title：Critical care (London, England)

authors： Volakli E,Spies C,Michalopoulos A,Groeneveld AB,Sakr Y,Vincent JL

更新日期：2010-01-01 00:00:00

abstract：:Organ donation offers opportunities for people in critical care units to help save the lives of other patients. It is not always easy, however, to handle the transition from treating a patient to preserving a potential donor, and organ donation consistently provokes ethical questions in critical care units. What do we...

journal_title：Critical care (London, England)

authors： Hoeyer K,Jensen AM

更新日期：2011-01-24 00:00:00

abstract：:Determine the effectiveness of decontamination, and perform thorough dry or wet decontamination, depending on the circumstances. Always remain cognizant of the fact that, even after decontamination has been completed, contamination may not have been completely eliminated. Perform periodic monitoring to determine wheth...

journal_title：Critical care (London, England)

authors： Okumura S,Okumura T,Ishimatsu S,Miura K,Maekawa H,Naito T

更新日期：2005-08-01 00:00:00

abstract：INTRODUCTION:Expanding the criteria for deceased organ donors increases the risk of delayed graft function (DGF) and complicates kidney transplant outcome. We studied whether donor neutrophil gelatinase-associated lipocalin (NGAL), a novel biomarker for acute kidney injury, could predict DGF after transplantation. MET...

journal_title：Critical care (London, England)

authors： Hollmen ME,Kyllönen LE,Inkinen KA,Lalla ML,Merenmies J,Salmela KT

更新日期：2011-01-01 00:00:00

abstract：:Sepsis, despite recent therapeutic progress, still carries unacceptably high mortality rates. The adrenergic system, a key modulator of organ function and cardiovascular homeostasis, could be an interesting new therapeutic target for septic shock. Beta-adrenergic regulation of the immune function in sepsis is complex ...

journal_title：Critical care (London, England)

authors： de Montmollin E,Aboab J,Mansart A,Annane D

更新日期：2009-01-01 00:00:00

abstract：:The impressive benefits related to the use of tight glucose control by intensive insulin therapy have not been reproduced until now in multicenter large-scale prospective randomized trials. Although the reasons for these failures are not entirely clear, we suggest the use of a stepwise approach - Safe, Effective Gluco...

journal_title：Critical care (London, England)

authors： Krinsley JS,Preiser JC

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:To determine whether subjecting patients to 100 ml of additional dead space after a 120-minute weaning trial could predict readiness for extubation. METHODS:This was a prospective, non-randomised pilot study in an intensive care unit at a university hospital with 14 beds. It included all non-tracheostomis...

journal_title：Critical care (London, England)

authors： Solsona JF,Díaz Y,Vázquez A,Pilar Gracia M,Zapatero A,Marrugat J

更新日期：2009-01-01 00:00:00

abstract：:Since most common diseases have been shown to be influenced by inherited variations in our genes, completion of the Human Genome Project and mapping of the human genome single-nucleotide polymorphisms will have a tremendous impact on our approach to medicine. New developments in genotyping techniques and bioinformatic...

journal_title：Critical care (London, England)

authors： Chiche JD,Cariou A,Mira JP

更新日期：2002-06-01 00:00:00

abstract：INTRODUCTION:Mechanical ventilation (MV) with high tidal volumes may induce or aggravate lung injury in critical ill patients. We compared the effects of a protective versus a conventional ventilatory strategy, on systemic and lung production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8) in patien...

journal_title：Critical care (London, England)

authors： Pinheiro de Oliveira R,Hetzel MP,dos Anjos Silva M,Dallegrave D,Friedman G

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Critically ill cirrhosis patients awaiting liver transplantation (LT) often receive prioritization for organ allocation. Identification of patients most likely to benefit is essential. The purpose of this study was to examine whether the Sequential Organ Failure Assessment (SOFA) score can predict 90-day m...

journal_title：Critical care (London, England)

authors： Karvellas CJ,Lescot T,Goldberg P,Sharpe MD,Ronco JJ,Renner EL,Vahidy H,Poonja Z,Chaudhury P,Kneteman NM,Selzner M,Cook EF,Bagshaw SM,Canadian Liver Failure Study Group.

更新日期：2013-02-09 00:00:00

abstract：BACKGROUND:Neurological deterioration after intracerebral hemorrhage (ICH) is thought to be closely related to increased intracranial pressure (ICP), decreased cerebral blood flow (CBF), and brain metabolism. Transcranial Doppler (TCD) is increasingly used as an indirect measure of ICP, and quantitative EEG (QEEG) can ...

journal_title：Critical care (London, England)

authors： Chen Y,Xu W,Wang L,Yin X,Cao J,Deng F,Xing Y,Feng J

更新日期：2018-02-20 00:00:00