Vaginal microbiome in women from Greenland assessed by microscopy and quantitative PCR.

Abstract:

BACKGROUND:Bacterial vaginosis (BV) is a common condition, although its aetiology remains unexplained. The aim of this study was to analyse the composition of vaginal microbiota in women from Greenland to provide a quantitative description and improve the understanding of BV. METHODS:Self-collected vaginal smears and swabs were obtained from 177 women. The vaginal smears were graded for BV according to Nugent's criteria. The vaginal swab samples were analysed by 19 quantitative PCRs (qPCRs) for selected vaginal bacteria and by PCR for four sexually transmitted infections (STIs). RESULTS:STIs were common: Mycoplasma genitalium 12%, Chlamydia trachomatis 7%, Neisseria gonorrhoeae 1%, and Trichomonas vaginalis 0.5%. BV was found in 45% of women, but was not associated with individual STIs. Seven of the 19 vaginal bacteria (Atopobium vaginae, Prevotella spp., Gardnerella vaginalis, BVAB2, Eggerthella-like bacterium, Leptotrichia amnionii, and Megasphaera type 1) had areas under the receiver operating characteristic (ROC) curve > 85%, suggesting they are good predictors of BV according to Nugent. Prevotella spp. had the highest odds ratio for BV (OR 437; 95% CI 82-2779) in univariate analysis considering only specimens with a bacterial load above the threshold determined by ROC curve analysis as positive, as well as the highest adjusted odds ratio in multivariate logistic regression analysis (OR 4.4; 95% CI 1.4-13.5). BV could be subdivided into clusters dominated by a single or a few species together. CONCLUSIONS:BV by Nugent score was highly prevalent. Two of seven key species (Prevotella spp. and A. vaginae) remained significantly associated with BV in a multivariate model after adjusting for other bacterial species. G. vaginalis and Prevotella spp. defined the majority of BV clusters.

journal_name

BMC Infect Dis

journal_title

BMC infectious diseases

authors

Datcu R,Gesink D,Mulvad G,Montgomery-Andersen R,Rink E,Koch A,Ahrens P,Jensen JS

doi

10.1186/1471-2334-13-480

subject

Has Abstract

pub_date

2013-10-16 00:00:00

pages

480

issn

1471-2334

pii

1471-2334-13-480

journal_volume

13

pub_type

杂志文章
  • Clinical and microbiological characteristics of bloodstream infections due to AmpC β-lactamase producing Enterobacteriaceae: an active surveillance cohort in a large centralized Canadian region.

    abstract:BACKGROUND:The objective of this study was to describe the clinical and microbiological characteristics of bloodstream infections (BSIs) due to AmpC producing Enterobacteriaceae (AE) in a large centralized Canadian region over a 9-year period. METHODS:An active surveillance cohort design in Calgary, Canada. RESULTS:A...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-014-0647-4

    authors: Chaubey VP,Pitout JD,Dalton B,Gregson DB,Ross T,Laupland KB

    更新日期:2014-12-14 00:00:00

  • Prevalence of hepatitis B and hepatitis C infection in Libya: results from a national population based survey.

    abstract:BACKGROUND:Libya is one of the largest countries in Africa and has the longest coast in the Mediterranean basin facing southern Europe. High rates of prevalence of viral hepatitis have been observed in various regions in Africa, but the prevalence in Libya is not well documented. We report on a large-scale nationwide s...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-14-17

    authors: Daw MA,El-Bouzedi A,In association with Libyan Study Group of Hepatitis & HIV.

    更新日期:2014-01-09 00:00:00

  • Evaluation of Mycobacterium tuberculosis viability in OMNIgene-SPUTUM reagent upon multi-day transport at ambient temperature.

    abstract:BACKGROUND:Maintaining the quality of clinical specimens for tuberculosis (TB) testing is a major challenge in many high TB burden-limited resources countries. Sample referral systems in low and middle income countries are often weak and the maintenance of the cold-chain challenging and very costly for TB programs. The...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-017-2756-3

    authors: Tagliani E,Alagna R,Tafaj S,Hafizi H,Cirillo DM

    更新日期:2017-10-02 00:00:00

  • Associations of statins and antiretroviral drugs with the onset of type 2 diabetes among HIV-1-infected patients.

    abstract:BACKGROUND:Statin use is associated with a modest increase in the incidence of type 2 diabetes mellitus (DM) among the general population. However, HIV-infected patients have a higher risk of developing DM, and it is unclear whether statins have a diabetogenic effect in these patients. Therefore, we investigated the as...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-016-2099-5

    authors: Spagnuolo V,Galli L,Poli A,Salpietro S,Gianotti N,Piatti P,Cossarini F,Vinci C,Carini E,Lazzarin A,Castagna A

    更新日期:2017-01-07 00:00:00

  • Association among cytokine profiles of innate and adaptive immune responses and clinical-virological features in untreated patients with chronic hepatitis B.

    abstract:BACKGROUND:Complete clearance of intracellular viruses depends on effector cells of innate and adaptive immune systems. This study aimed to identify the relationships among antiviral cytokines produced by natural killer (NK) and T cells and clinical-virological characteristics in untreated chronic hepatitis B (CHB) pat...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-020-05233-x

    authors: Gu Y,Lian Y,Zheng Q,Huang Z,Gu L,Bi Y,Li J,Huang Y,Wu Y,Chen L,Huang Y

    更新日期:2020-07-14 00:00:00

  • A model-based economic analysis of pre-pandemic influenza vaccination cost-effectiveness.

    abstract:BACKGROUND:A vaccine matched to a newly emerged pandemic influenza virus would require a production time of at least 6 months with current proven techniques, and so could only be used reactively after the peak of the pandemic. A pre-pandemic vaccine, although probably having lower efficacy, could be produced and used p...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-14-266

    authors: Halder N,Kelso JK,Milne GJ

    更新日期:2014-05-16 00:00:00

  • Molecular characteristics of Clostridium difficile in children with acute gastroenteritis from Zhejiang.

    abstract:BACKGROUND:Clostridium difficile infection (CDI) has an increasing pediatric prevalence worldwide. However, molecular characteristics of C. difficile in Chinese children with acute gastroenteritis have not been reported. METHODS:A five-year cross-sectional study was conducted in a tertiary children's hospital in Zheji...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-020-05030-6

    authors: Shuai H,Bian Q,Luo Y,Zhou X,Song X,Ye J,Huang Q,Peng Z,Wu J,Jiang J,Jin D

    更新日期:2020-05-13 00:00:00

  • Application of quantitative second-line drug susceptibility testing at a multidrug-resistant tuberculosis hospital in Tanzania.

    abstract:BACKGROUND:Lack of rapid and reliable susceptibility testing for second-line drugs used in the treatment of multidrug-resistant tuberculosis (MDR-TB) may limit treatment success. METHODS:Mycobacterium tuberculosis isolates from patients referred to Kibong'oto National TB Hospital in Tanzania for second-line TB treatme...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-13-432

    authors: Mpagama SG,Houpt ER,Stroup S,Kumburu H,Gratz J,Kibiki GS,Heysell SK

    更新日期:2013-09-14 00:00:00

  • Using Baidu index to nowcast hand-foot-mouth disease in China: a meta learning approach.

    abstract:BACKGROUND:Hand, foot, and mouth disease (HFMD) has been recognized as one of the leading infectious diseases among children in China, which causes hundreds of annual deaths since 2008. In China, the reports of monthly HFMD cases usually have a delay of 1-2 months due to the time needed for collecting and processing cl...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-3285-4

    authors: Zhao Y,Xu Q,Chen Y,Tsui KL

    更新日期:2018-08-13 00:00:00

  • Predictors of failure of conservative treatment among patients with emphysematous pyelonephritis.

    abstract:BACKGROUND:Emphysematous pyelonephritis (EPN) is a severe necrotizing infection of the renal parenchyma and perirenal tissues that is caused by gas-producing bacterial pathogens. Percutaneous drainage is now the gold standard of definitive management. The aim of this study is to analyze the predictors associated with f...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-14-418

    authors: Lu YC,Chiang BJ,Pong YH,Huang KH,Hsueh PR,Huang CY,Pu YS

    更新日期:2014-07-29 00:00:00

  • Pharmacokinetics of quinacrine in the treatment of prion disease.

    abstract:BACKGROUND:Prion diseases are caused by the accumulation of an aberrantly folded isoform of the prion protein, designated PrPSc. In a cell-based assay, quinacrine inhibits the conversion of normal host prion protein (PrPC) to PrPSc at a half-maximal concentration of 300 nM. While these data suggest that quinacrine may ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-4-53

    authors: Yung L,Huang Y,Lessard P,Legname G,Lin ET,Baldwin M,Prusiner SB,Ryou C,Guglielmo BJ

    更新日期:2004-11-29 00:00:00

  • Molecular identification and antifungal susceptibility profile of Aspergillus flavus isolates recovered from clinical specimens in Kuwait.

    abstract:BACKGROUND:Within the genus Aspergillus, A. flavus is the second most important species of clinical significance. It is predominantly associated with infections involving sinuses, eye and skin, mostly in geographic regions with hot and arid climate, including the Middle East. Recent reports on emergence of resistance t...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-13-126

    authors: Al-Wathiqi F,Ahmad S,Khan Z

    更新日期:2013-03-06 00:00:00

  • Distribution of influenza virus types by age using case-based global surveillance data from twenty-nine countries, 1999-2014.

    abstract:BACKGROUND:Influenza disease burden varies by age and this has important public health implications. We compared the proportional distribution of different influenza virus types within age strata using surveillance data from twenty-nine countries during 1999-2014 (N=358,796 influenza cases). METHODS:For each virus, we...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-3181-y

    authors: Caini S,Spreeuwenberg P,Kusznierz GF,Rudi JM,Owen R,Pennington K,Wangchuk S,Gyeltshen S,Ferreira de Almeida WA,Pessanha Henriques CM,Njouom R,Vernet MA,Fasce RA,Andrade W,Yu H,Feng L,Yang J,Peng Z,Lara J,Bruno A,d

    更新日期:2018-06-08 00:00:00

  • Disease burden of herpes zoster in Sweden--predominance in the elderly and in women - a register based study.

    abstract:BACKGROUND:The herpes zoster burden of disease in Sweden is not well investigated. There is no Swedish immunization program to prevent varicella zoster virus infections. A vaccine against herpes zoster and its complications is now available. The aim of this study was to estimate the herpes zoster burden of disease and ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-13-586

    authors: Studahl M,Petzold M,Cassel T

    更新日期:2013-12-12 00:00:00

  • Temporal instability of the post-surgical maxillary sinus microbiota.

    abstract:BACKGROUND:Chronic rhinosinusitis is an inflammatory disorder in which the role of bacteria remains uncertain. While sinus outflow obstruction is often an initiating event, mucosal inflammation and dysbiosis may persist or develop in sinuses with widely patent surgical openings. Understanding of the relationship betwee...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-3272-9

    authors: Koutsourelakis I,Halderman A,Khalil S,Hittle LE,Mongodin EF,Lane AP

    更新日期:2018-08-30 00:00:00

  • Development and evaluation of an in-house single step loop-mediated isothermal amplification (SS-LAMP) assay for the detection of Mycobacterium tuberculosis complex in sputum samples from Moroccan patients.

    abstract:BACKGROUND:Tuberculosis (TB) is a major global health problem and remains the leading cause of morbidity and mortality in developing countries. Routinely used TB diagnostic methods, in most endemic areas, are time-consuming, often less-sensitive, expensive and inaccessible to most patients. Therefore, there is an urgen...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-016-1864-9

    authors: Bentaleb EM,Abid M,El Messaoudi MD,Lakssir B,Ressami EM,Amzazi S,Sefrioui H,Ait Benhassou H

    更新日期:2016-09-27 00:00:00

  • Multifocal motor neuropathy presenting as a post-infectious complication of dengue: a CASE report.

    abstract:BACKGROUND:Dengue infection is an endemic illness in the tropics and it is associated with a wide variety of post infectious complications. With the increasing prevalence of dengue infection in endemic regions, post-infectious neurological complications following dengue infection are now been reported more frequently. ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-3334-z

    authors: Higgoda R,Perera D,Thirumavalavan K

    更新日期:2018-08-22 00:00:00

  • Reproductive and genital health and risk of cervical human papillomavirus infection: results from the Ludwig-McGill cohort study.

    abstract:BACKGROUND:There are inconsistencies in the literature on reproductive and genital health determinants of human papillomavirus (HPV) infection, the primary cause of cervical cancer. We examined these factors in the Ludwig-McGill Cohort Study, a longitudinal, repeated-measurements investigation on the natural history of...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-016-1446-x

    authors: Shaw E,Ramanakumar AV,El-Zein M,Silva FR,Galan L,Baggio ML,Villa LL,Franco EL,Ludwig-McGill Cohort Study.

    更新日期:2016-03-08 00:00:00

  • Prevalence, clinical and economic burden of mucormycosis-related hospitalizations in the United States: a retrospective study.

    abstract:BACKGROUND:Mucormycosis is a rare but devastating fungal infection primarily affecting immunocompromised patients such as those with hematological malignancy, bone marrow and solid organ transplantation, and patients with diabetes, and, even more rarely, immunocompetent patients. The objective of this study was to asse...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-016-2023-z

    authors: Kontoyiannis DP,Yang H,Song J,Kelkar SS,Yang X,Azie N,Harrington R,Fan A,Lee E,Spalding JR

    更新日期:2016-12-01 00:00:00

  • Typhoid fever as a cause of opportunistic infection: case report.

    abstract:BACKGROUND:Typhoid fever is a systemic infection caused by the bacterium Salmonella enterica subspecies enterica serotype typhi, which is acquired by ingestion of contaminated food and water. Each year the disease affects at least 16 million persons world-wide, most of whom reside in the developing countries of Southea...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-6-38

    authors: Colomba C,Saporito L,Infurnari L,Tumminia S,Titone L

    更新日期:2006-02-27 00:00:00

  • QuantiFERON-TB gold in-tube implementation for latent tuberculosis diagnosis in a public health clinic: a cost-effectiveness analysis.

    abstract:BACKGROUND:The tuberculin skin test (TST) has limitations for latent tuberculosis infection (LTBI) diagnosis in low-prevalence settings. Previously, all TST-positive individuals referred from the community to Baltimore City Health Department (BCHD) were offered LTBI treatment, after active TB was excluded. In 2010, BCH...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-12-360

    authors: Shah M,Miele K,Choi H,DiPietro D,Martins-Evora M,Marsiglia V,Dorman S

    更新日期:2012-12-19 00:00:00

  • A population-based study to investigate host genetic factors associated with hepatitis B infection and pathogenesis in the Chinese population.

    abstract:BACKGROUND:Hepatitis B virus (HBV) infection is a significant public health problem that may lead to chronic liver disease, cirrhosis, and hepatocellular carcinoma (HCC). Approximately 30% of the world's population has been infected with HBV and approximately 350 million (5-6%) are persistent carriers. More than 120 mi...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2334-8-1

    authors: Zeng Z,Guan L,An P,Sun S,O'Brien SJ,Winkler CA,HBV study consortium.

    更新日期:2008-01-02 00:00:00

  • Examining the online approaches used by hospitals in Sydney, Australia to inform patients about healthcare associated infections and infection prevention strategies.

    abstract:BACKGROUND:Provision of information plays a critical role in supporting patients to be engaged or empowered to be involved with infection prevention measures in hospitals. This explorative study evaluated the suitability, readability and accessibility of information on healthcare associated infections (HCAIs) and infec...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-017-2899-2

    authors: Park J,Seale H

    更新日期:2017-12-21 00:00:00

  • Association between tumor necrosis factor alpha-238G/a polymorphism and tuberculosis susceptibility: a meta-analysis study.

    abstract:BACKGROUND:Tumor necrosis factor alpha (TNF-α) plays a key role in the containment of tuberculosis. The relationship between the TNF -238G/A polymorphism and tuberculosis susceptibility remains inconclusive. A comprehensive meta-analysis was made to provide a more precise estimate of the relationship between them. MET...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,meta分析

    doi:10.1186/1471-2334-12-328

    authors: Zhang Z,Zhu H,Pu X,Meng S,Zhang F,Xun L,Liu Q,Wang Y

    更新日期:2012-11-28 00:00:00

  • The latent tuberculosis infection cascade of care in Iqaluit, Nunavut, 2012-2016.

    abstract:BACKGROUND:A remote arctic region of Canada predominantly populated by Inuit with the country's highest incidence of tuberculosis. METHODS:The study was undertaken to describe the latent tuberculosis infection (LTBI) cascade of care and identify factors associated with non-initiation and non-completion of LTBI treatme...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-019-4557-3

    authors: Pease C,Zwerling A,Mallick R,Patterson M,Demaio P,Finn S,Allen J,Van Dyk D,Alvarez GG

    更新日期:2019-10-24 00:00:00

  • Endotoxin tolerance and cross-tolerance in mast cells involves TLR4, TLR2 and FcepsilonR1 interactions and SOCS expression: perspectives on immunomodulation in infectious and allergic diseases.

    abstract:BACKGROUND:The study of the endotoxin tolerance phenomenon in light of the recently defined roles of mast cells and toll-like receptors as essential components of the innate immune response and as orchestrators of acquired immunity may reveal potentially useful mechanisms of immunomodulation of infectious and allergic ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-10-240

    authors: Saturnino SF,Prado RO,Cunha-Melo JR,Andrade MV

    更新日期:2010-08-14 00:00:00

  • Retrospective analysis of acute HBV infections occurred in 1978-79 and 1994-95 in North-East Italy: increasing prevalence of BCP/pre-core mutants in sub-genotype D3.

    abstract:BACKGROUND:At the end of the 1970s, in Italy more than 2% of the general population was HBsAg carrier. In the late '70s and late '80s, two remarkable events might have impacted on HBV strains transmitted in North-East Italy: (a) the increased HBV incidence due to parenteral drugs between 1978 and 1982; (b) the preventi...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-019-4713-9

    authors: Bruni R,Villano U,Taffon S,Equestre M,Madonna E,Chionne P,Candido A,Dettori S,Pisani G,Rapicetta M,Bortolotti F,Ciccaglione AR

    更新日期:2020-01-28 00:00:00

  • An assessment of the usefulness of a rapid immuno-chromatographic test, "Determine trade mark malaria pf" in evaluation of intervention measures in forest villages of central India.

    abstract:BACKGROUND:Plasmodium falciparum malaria, is a major health problem in forested tribal belt of central India. Rapid and accurate methods are needed for the diagnosis of P. falciparum. We performed a blinded evaluation of the recently introduced Determine trade mark malaria pf test (Abbott, Laboratories, Japan) compared...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-1-10

    authors: Singh N,Shukla M

    更新日期:2001-01-01 00:00:00

  • Effects of infection and disease with Mycobacterium tuberculosis on serum antibody to glucan and arabinomannan: two surface polysaccharides of this pathogen.

    abstract:BACKGROUND:The role of the surface capsular polysaccharides (CPs) of Mycobacterium tuberculosis (Mtb) in the pathogenesis of infection and disease, as well their potential for use as diagnostic reagents and vaccine antigens, are unknown. METHODS:Serum antibody to two CPs of Mtb, arabinomannan (AM) and glucan (Glu), we...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-13-276

    authors: Keitel WA,Dai Z,Awe RW,Atmar RL,Morris S,Schneerson R,Robbins JB

    更新日期:2013-06-19 00:00:00

  • Factors related to outcome of bloodstream infections due to Candida parapsilosis complex.

    abstract:BACKGROUND:Although Candida albicans is the most common cause of fungal blood stream infections (BSIs), infections due to Candida species other than C. albicans are rising. Candida parapsilosis complex has emerged as an important fungal pathogen and became one of the main causes of fungemia in specific geographical are...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-016-1704-y

    authors: Barchiesi F,Orsetti E,Osimani P,Catassi C,Santelli F,Manso E

    更新日期:2016-08-09 00:00:00