Abstract：
BACKGROUND:A remote arctic region of Canada predominantly populated by Inuit with the country's highest incidence of tuberculosis. METHODS:The study was undertaken to describe the latent tuberculosis infection (LTBI) cascade of care and identify factors associated with non-initiation and non-completion of LTBI treatment. Data were extracted retrospectively from medical records for all patients with a tuberculin skin test (TST) implanted in Iqaluit, Nunavut between January 2012 and March 2016. Associations between demographic and clinical factors and both treatment non-initiation among and treatment non-completion were identified using log binomial regression models where convergence could be obtained and Poisson models with robust error variance where convergence was not obtained. RESULTS:Of 2303 patients tested, 439 (19.1%) were diagnosed with LTBI. Treatment was offered to 328 patients, was initiated by 246 (75.0% of those offered) and was completed by 186 (75.6% of initiators). In multivariable analysis, older age (adjust risk ratio [aRR] 1.17 per 5-year increase, 95%CI:1.09-1.26) and undergoing TST due to employment screening (aRR 1.63, 95%CI:1.00-2.65, compared to following tuberculosis exposure) were associated with increased non-initiation of treatment. Older age (aRR 1.13, 95%CI: 1.03-1.17, per 5-year increase) was associated with increased non-completion of treatment. CONCLUSIONS:A similar rate of treatment initiation and higher rate of treatment completion were found compared to previous North American studies. Interventions targeting older individuals and those identified via employment screening may be considered to help to address the largest losses in the cascade of care.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Pease C,Zwerling A,Mallick R,Patterson M,Demaio P,Finn S,Allen J,Van Dyk D,Alvarez GGdoi
10.1186/s12879-019-4557-3subject
Has Abstractpub_date
2019-10-24 00:00:00pages
890issue
1issn
1471-2334pii
10.1186/s12879-019-4557-3journal_volume
19pub_type
杂志文章abstract：BACKGROUND:Scrub typhus is a zoonotic disease caused by Orientia tsutsugamushi, a gram-negative intracellular bacterium. Myocarditis and rhabdomyolysis are rare complications of scrub typhus. CASE PRESENTATION:We report a case of scrub typhus, which was simultaneously complicated with myocarditis and rhabdomyolysis. A...
journal_title：BMC infectious diseases
pub_type： 杂志文章
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journal_title：BMC infectious diseases
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:Patients with HIV infection are at risk of co-infection with HBV, as the routes of transmission are shared and thus immunization with HBV vaccine could be protective in them. The aim of the present study was to assess the efficacy of recombinant vaccine in treatment-naive HIV positive patients and healthy co...
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pub_type： 杂志文章
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更新日期：2014-11-07 00:00:00
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更新日期：2013-09-03 00:00:00
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更新日期：2015-05-05 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2012-11-06 00:00:00
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pub_type： 杂志文章,已发布勘误
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更新日期：2020-02-27 00:00:00
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pub_type： 杂志文章
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更新日期：2014-05-16 00:00:00
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更新日期：2012-08-01 00:00:00
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更新日期：2018-11-06 00:00:00
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更新日期：2020-02-26 00:00:00
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pub_type： 杂志文章,meta分析
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更新日期：2020-03-04 00:00:00
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更新日期：2016-10-13 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2020-02-24 00:00:00
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