Abstract：
BACKGROUND:Data regarding HIV-seronegative pediatric patients with cryptococcal meningitis (CM) have been very limited. METHODS:We retrospectively reviewed non-HIV-infected in patients with CM from January 2002 through December 2013 in Beijing Children's Hospital. Records of the all patients were obtained and compared. RESULTS:The 34 children had a median age of 5.6 years. Most of the patients were male (67.6 %). Only 23.5 % of the cases had identifiable underlying diseases. The sensitivity of the CSF cryptococcal antigen, India ink smear and CSF culture in our study were 81.5, 85.3 and 82.4 %, respectively. And the sensitivity of combinations of these tests was 91.2 %. Out of the 34 patients, 16 (47.1 %) had other organs involvement in addition to the brain. The main abnormal features via magnetic resonance imaging (MRI) were Virchow-Robin space dilatation (44.4 %), hydrocephalus (38.9 %), gelatinous pseudocysts (33.3 %), brain atrophy (33.3 %), meningeal enhancement (27.8 %) and local lesions (27.8 %). In total, 64.7 % of the patients were successfully treated at discharge, whereas treatment failed in 35.3 % of the patients. CONCLUSIONS:Cryptococcal meningitis is an infrequent disease with a high fatality rate in children in China. The majority of patients were apparently healthy. Clinicians should consider cryptococcal infection as a potential pathogen of pediatric meningitis. Cryptococcal antigen, India ink smear and culture tests are recommended for diagnosis.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Guo LY,Liu LL,Liu Y,Chen TM,Li SY,Yang YH,Liu Gdoi
10.1186/s12879-016-1964-6subject
Has Abstractpub_date
2016-11-04 00:00:00pages
635issue
1issn
1471-2334pii
10.1186/s12879-016-1964-6journal_volume
16pub_type
杂志文章abstract：BACKGROUND:COVID-19 is an emerging respiratory disease caused by a novel coronavirus. There is not much evidence assessing the knowledge of dental surgeons regarding COVID-19. This study was conducted to assess the knowledge of COVID-19 among dental surgeons of Nepal. METHODS:A web-based cross-sectional study was cond...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-020-05620-4
更新日期：2020-11-23 00:00:00
abstract：BACKGROUND:The ocular manifestations of HIV may lead to visual impairment or blindness. In India, patients typically initiate antiretroviral treatment (ART) with low CD4 cell counts when the risk of ocular complications may be high. The objective of this study was to determine the prevalence and types of HIV-associated...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-9-158
更新日期：2009-09-23 00:00:00
abstract：BACKGROUND:While most cases of polymicrobial vertebral osteomyelitis are secondary to hematogenous seeding, direct inoculation during spinal surgery and contiguous spread from adjacent soft tissue are also potential routes whereby pathogens may infect the spine. CASE PRESENTATION:A 74 year-old man presented with an ex...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-016-1471-9
更新日期：2016-03-31 00:00:00
abstract：BACKGROUND:The rapid identification of acid-fast bacilli recovered from patient specimens as Mycobacterium tuberculosis complex (MTC) is critically important for accurate diagnosis and treatment. A thin-layer immunochromatographic (TLC) assay using anti-MPB64 or anti-MPT64 monoclonal antibodies was developed to discrim...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-14-54
更新日期：2014-02-01 00:00:00
abstract：BACKGROUND:In France, 1/3 HIV-infected patients is diagnosed at an advanced stage of the disease. We describe missed opportunities for earlier HIV testing in newly-HIV-diagnosed patients. METHODS:Cross sectional study. Adults living in France for ≥1 year, diagnosed with HIV-infection ≤6 months earlier, were included f...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-13-200
更新日期：2013-05-02 00:00:00
abstract：BACKGROUND:In Lao PDR, the epidemiology of varicella infection is uncertain, since it is not a notifiable disease and VZV outbreaks are rarely reported as fever/rash (F/R) diseases. METHODS:We estimated the seroprevalence of VZV (IgG ELISA) in different age cohorts (9 months to 46 years; N = 3139) and investigated VZV...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-019-3990-7
更新日期：2019-05-08 00:00:00
abstract：BACKGROUND:In vitro data suggests that suboptimal initial vancomycin exposure may select for heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) infections. However, no clinical studies have evaluated the relationship between initial vancomycin exposure and emergence of hVISA. This pilot study seeks to ...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-017-2609-0
更新日期：2017-08-02 00:00:00
abstract：BACKGROUND:The aim of this study was to determine the distribution of vancomycin and daptomycin MICs among methicillin-resistant Staphylococcus aureus (MRSA) blood isolates, the prevalence of heterogeneous vancomycin-intermediate S. aureus (hVISA) and the relationship between hVISA and vancomycin MIC values. METHODS:A...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-13-583
更新日期：2013-12-10 00:00:00
abstract：BACKGROUND:Altered fat distribution and chronic inflammation are found in both persons living with HIV (PLWH) and persons with diabetes mellitus type 2 (DM2) and are known risk factors for cardiovascular diseases (CVD). We aimed to investigate if a synergistic effect of HIV infection and DM2 was found on fat distributi...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-020-05594-3
更新日期：2020-11-25 00:00:00
abstract：BACKGROUND:Variations of porB1A and porB1B genes and their serotypes exist in Neisseria gonorrhoeae isolates from different geographical areas, and some site mutations in the porB1B gene correlate with drug resistance. METHODS:The β-lactamase production of N. gonorrhoeae isolates was determined by paper acidometric te...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-10-323
更新日期：2010-11-10 00:00:00
abstract：BACKGROUND:Human papillomavirus (HPV) is one of the most common sexually-transmitted pathogens. A number of studies in the literature have estimated the burden of HPV-related diseases by collecting data at primary care level, while a comprehensive assessment of the global burden of HPV-related diseases on hospital reso...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-13-462
更新日期：2013-10-05 00:00:00
abstract：BACKGROUND:Culturing has long been the gold standard for detecting aetiologic agents in bacterial infections. In some cases, however, culturing fails to detect the infection. To further investigate culture-negative samples, amplification and subsequent sequencing of the 16S rRNA gene is often applied. The aim of the pr...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-017-2333-9
更新日期：2017-03-27 00:00:00
abstract：BACKGROUND:Undernutrition is one of the most common problems among people living with HIV, contributing to premature death and the development of comorbidities within this population. In Sub-Saharan Africa (SSA), the impacts of these often inter-related conditions appear in a series of fragmented and inconclusive studi...
journal_title：BMC infectious diseases
pub_type： 杂志文章,meta分析
doi：10.1186/s12879-020-05706-z
更新日期：2021-01-04 00:00:00
abstract：BACKGROUND:Between November 2 and 10, 2002 several patients with psoriasis and personnel staying in the health centre in Gran Canaria, Spain fell ill with diarrhoea, vomiting or both. Patient original came from Norway, Sweden and Finland. The patient group was scheduled to stay until 8 November. A new group of patients...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-4-45
更新日期：2004-10-29 00:00:00
abstract：BACKGROUND:Despite a resurgence in control efforts, malaria remains a serious public-health problem, causing millions of deaths each year. One factor that complicates malaria-control efforts is clinical immunity, the acquired immune response that protects individuals from symptoms despite the presence of parasites. Cli...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-13-428
更新日期：2013-09-11 00:00:00
abstract：BACKGROUND:Typhoid fever is a systemic infection caused by the bacterium Salmonella enterica subspecies enterica serotype typhi, which is acquired by ingestion of contaminated food and water. Each year the disease affects at least 16 million persons world-wide, most of whom reside in the developing countries of Southea...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-6-38
更新日期：2006-02-27 00:00:00
abstract：BACKGROUND:Several highly pathogenic avian influenza (AI) outbreaks have been reported over the past decade. South Korea recently faced AI outbreaks whose economic impact was estimated to be 6.3 billion dollars, equivalent to nearly 50% of the profit generated by the poultry-related industries in 2008. In addition, AI ...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-10-236
更新日期：2010-08-10 00:00:00
abstract：BACKGROUND:Tuberculosis remains a serious threat to human health as an infectious disease in China. Henan, a most populated province in China, has a high incidence of tuberculosis (TB). Though the genetic diversity of Mycobacterium tuberculosis (MTB) has been investigated in many regions, there have been only a few stu...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-018-3351-y
更新日期：2018-09-03 00:00:00
abstract：BACKGROUND:Hospital-based surveillance for pneumococcal meningitis has been conducted since January 1996 in the city of Salvador, Brazil. The purpose of this study was to describe the temporal evolution of Penicillin Non-Susceptible Streptococcus pneumoniae (PNSSP) in regards to serotype distributions and clonal divers...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-015-1049-y
更新日期：2015-07-30 00:00:00
abstract：BACKGROUND:Severe falciparum malaria may be complicated by prolonged haemolysis and recurrent fever after parasite clearance. However, their respective etiologies are unclear and challenging to diagnose. We report the first case of severe falciparum malaria followed by prolonged haemolytic anaemia and rhinomaxillary mu...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-015-1285-1
更新日期：2015-12-03 00:00:00
abstract：BACKGROUND:Human Parainfluenza Virus (hPIV) causes severe respiratory illness in infants and adults. Our study describes the association of hPIV1-4 with bronchiolitis, croup, and pneumonia using retrospective laboratory, administrative and public health data. Due to issues including the historic lack of hPIV4 in some c...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-016-1748-z
更新日期：2016-08-11 00:00:00
abstract：BACKGROUND:Staphylococcus aureus bacteraemia (SAB) causes considerable morbidity and mortality in children. Despite this, its epidemiology and risk factors are poorly understood, with minimal paediatric clinical trial data available to guide clinicians in management. We conducted a pilot study to characterise SAB and v...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-018-3312-5
更新日期：2018-08-10 00:00:00
abstract：BACKGROUND:Isoniazid (INH) represents the cornerstone for the treatment of cases infected with Mycobacterium tuberculosis (MTB) strains. Several molecular mechanisms have been shown to be the major causes for INH resistance, while the dynamic change of mutations conferring INH resistance among MTB strains during the pa...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-019-4333-4
更新日期：2019-08-05 00:00:00
abstract：BACKGROUND:High seroprevalence of parvovirus B19 (B19V) coinfection with Plasmodium falciparum has been previously reported. However, the impact of B19V-infection on the clinical course of malaria is still elusive. In this study, we investigated the prevalence and clinical significance of B19V co-infection in Gabonese ...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-13-375
更新日期：2013-08-15 00:00:00
abstract：BACKGROUND:Annual influenza vaccination of healthcare workers (HCWs) is recommended in Australia, but uptake in healthcare facilities has historically been low (approximately 50%). The objective of this study was to develop and implement a dedicated campaign to improve uptake of staff influenza annual vaccination at a ...
journal_title：BMC infectious diseases
pub_type： 杂志文章,多中心研究
doi：10.1186/s12879-015-0765-7
更新日期：2015-02-06 00:00:00
abstract：BACKGROUND:The occurrence of antibiotic resistant Neisseria gonorrhoeae isolates is a serious public health problem in different corners of the globe. The objective of this study was to analyze the antimicrobial susceptibility pattern of N. gonorrhoeae in Northwest Ethiopia. METHODS:This was a retrospective study of N...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-13-415
更新日期：2013-09-05 00:00:00
abstract：BACKGROUND:Compared to methicillin-resistant Staphylococcus aureus (MRSA), characteristics of nasal carriage and community-onset infection methicillin-susceptible S. aureus (MSSA) are less well known. No characteristics of MSSA in Taiwan have been reported previously. METHODS:We analyzed 100 nasal carriage and 34 comm...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-12-343
更新日期：2012-12-10 00:00:00
abstract：BACKGROUND:Nitric oxide (NO) produced in macrophages plays a pivotal role as a leishmanicidal agent. A previous study has demonstrated that 20% of the L. (V.) braziliensis isolated from initial cutaneous lesions of patients from the endemic area of Corte de Pedra, Bahia, Brazil, were NO resistant. Additionally, 5 to 11...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-10-209
更新日期：2010-07-15 00:00:00
abstract：BACKGROUND:The Middle East respiratory syndrome (MERS) is proposed to be a zoonotic disease. Dromedary camels have been implicated due to reports that some confirmed cases were exposed to camels. Risk factors for MERS coronavirus (MERS-CoV) infections in humans are incompletely understood. This study aimed to describe ...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-016-2137-3
更新日期：2017-01-05 00:00:00
abstract：BACKGROUND:We estimated the nationwide burden of nosocomial S. aureus bloodstream infection (SA-BSI), a major cause of nosocomial infection, in South Korea. METHODS:To evaluate the nationwide incidence of nosocomial SA-BSI, cases of SA-BSI were prospectively collected from 22 hospitals with over 500 beds over 4?months...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-014-0590-4
更新日期：2014-11-14 00:00:00
