Host biomarkers distinguish dengue from leptospirosis in Colombia: a case-control study.

Abstract:

BACKGROUND:Dengue fever and leptospirosis have partially overlapping geographic distributions, similar clinical presentations and potentially life-threatening complications but require different treatments. Distinguishing between these cosmopolitan emerging pathogens represents a diagnostic dilemma of global importance. We hypothesized that perturbations in host biomarkers can differentiate between individuals with dengue fever and leptospirosis during the acute phase of illness. METHODS:We randomly selected subjects from a prospective cohort study of acute febrile illness in Bucaramanga, Colombia and tested 19 serum biomarkers by ELISA in dengue fever (DF, n = 113) compared to subjects with leptospirosis (n = 47). Biomarkers were selected for further analysis if they had good discriminatory ability (area under the ROC curve (AUC) >0.80) and were beyond a reference range (assessed using local healthy controls). RESULTS:Nine biomarkers differed significantly between dengue fever and leptospirosis, with higher levels of Angptl3, IL-18BP, IP-10/CXCL10, Platelet Factor 4, sICAM-1, Factor D, sEng and sKDR in dengue and higher levels of sTie-2 in leptospirosis (p < 0.001 for all comparisons). Two biomarkers, sEng and IL18BP, showed excellent discriminatory ability (AUROC >0.90). When incorporated into multivariable models, sEng and IL18BP improved the diagnostic accuracy of clinical information alone. CONCLUSIONS:These results suggest that host biomarkers may have utility in differentiating between dengue and leptospirosis, clinically similar conditions of different etiology.

journal_name

BMC Infect Dis

journal_title

BMC infectious diseases

authors

Conroy AL,Gélvez M,Hawkes M,Rajwans N,Liles WC,Villar-Centeno LA,Kain KC

doi

10.1186/1471-2334-14-35

subject

Has Abstract

pub_date

2014-01-20 00:00:00

pages

35

issn

1471-2334

pii

1471-2334-14-35

journal_volume

14

pub_type

杂志文章
  • Interpretation of serial interferon-gamma test results to measure new tuberculosis infection among household contacts in Zambia and South Africa.

    abstract:BACKGROUND:A more stringent QuantiFERON-TB Gold In-Tube (QFT) conversion (from negative to positive) definition has been proposed to allow more definite detection of recent tuberculosis (TB) infection. We explored alternative conversion definitions to assist the interpretation of serial QFT results and estimate inciden...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/s12879-020-05483-9

    authors: Sloot R,Shanaube K,Claassens M,Telisinghe L,Schaap A,Godfrey-Faussett P,Ayles H,Floyd S

    更新日期:2020-10-15 00:00:00

  • Completeness of tuberculosis case notifications in Germany in 2013-2017: first results of an inventory study.

    abstract:BACKGROUND:Evaluating the completeness of tuberculosis (TB) notification data is important for monitoring of TB surveillance systems. We conducted an inventory study to calculate TB underreporting in Germany in 2013-2017. METHODS:Acquisition of two pseudonymized case-based data sources (national TB notification data a...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-020-05467-9

    authors: Domaszewska T,Karo B,Preuss U,Kollan C,Reuss A,Blank HP,Brodhun B,Hauer B,Altmann D,Fiebig L,Haas W,Perumal N

    更新日期:2020-10-17 00:00:00

  • Relationship between day 1 and day 2 Vancomycin area under the curve values and emergence of heterogeneous Vancomycin-intermediate Staphylococcus aureus (hVISA) by Etest® macromethod among patients with MRSA bloodstream infections: a pilot study.

    abstract:BACKGROUND:In vitro data suggests that suboptimal initial vancomycin exposure may select for heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) infections. However, no clinical studies have evaluated the relationship between initial vancomycin exposure and emergence of hVISA. This pilot study seeks to ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-017-2609-0

    authors: Martirosov DM,Bidell MR,Pai MP,Scheetz MH,Rosenkranz SL,Faragon C,Malik M,Mendes RE,Jones RN,McNutt LA,Lodise TP

    更新日期:2017-08-02 00:00:00

  • Association among cytokine profiles of innate and adaptive immune responses and clinical-virological features in untreated patients with chronic hepatitis B.

    abstract:BACKGROUND:Complete clearance of intracellular viruses depends on effector cells of innate and adaptive immune systems. This study aimed to identify the relationships among antiviral cytokines produced by natural killer (NK) and T cells and clinical-virological characteristics in untreated chronic hepatitis B (CHB) pat...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-020-05233-x

    authors: Gu Y,Lian Y,Zheng Q,Huang Z,Gu L,Bi Y,Li J,Huang Y,Wu Y,Chen L,Huang Y

    更新日期:2020-07-14 00:00:00

  • Basis for treatment of tuberculosis among HIV-infected patients in Tanzania: the role of chest x-ray and sputum culture.

    abstract:BACKGROUND:Active tuberculosis (TB) is common among HIV-infected persons living in tuberculosis endemic countries, and screening for tuberculosis (TB) is recommended routinely. We sought to determine the role of chest x-ray and sputum culture in the decision to treat for presumptive TB using active case finding in a la...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-8-32

    authors: Bakari M,Arbeit RD,Mtei L,Lyimo J,Waddell R,Matee M,Cole BF,Tvaroha S,Horsburgh CR,Soini H,Pallangyo K,von Reyn CF

    更新日期:2008-03-06 00:00:00

  • Association of TGF-ß1 polymorphisms and chronic hepatitis C infection: a Meta-analysis.

    abstract:BACKGROUND:Although several researches have reported the connection between the transforming growth factor-beta 1 (TGF-β1) gene polymorphisms and chronic hepatitis C virus (HCV) infection, the conclusions of these studies were not always consistent. Here, this paper proposed a meta-analysis to evaluate whether the TGF-...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12879-019-4390-8

    authors: Guo P,Liu S,Sun X,Xu L

    更新日期:2019-08-30 00:00:00

  • Factors associated with sepsis development in 606 Spanish adult patients with cellulitis.

    abstract:BACKGROUND:Cellulitis, a frequent cause of admission of adult patients to medical wards, occasionally evolves to sepsis. In this study we analyze the factors related to sepsis development. METHODS:Prospective and observational study of 606 adult patients with cellulitis admitted to several Spanish hospitals. Comorbidi...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-020-4915-1

    authors: Collazos J,de la Fuente B,de la Fuente J,García A,Gómez H,Menéndez C,Enríquez H,Sánchez P,Alonso M,López-Cruz I,Martín-Regidor M,Martínez-Alonso A,Guerra J,Artero A,Blanes M,Asensi V

    更新日期:2020-03-12 00:00:00

  • Anopheles coluzzii larval habitat and insecticide resistance in the island area of Manoka, Cameroon.

    abstract:BACKGROUND:The effectiveness of Long-Lasting Insecticidal Nets and Indoor Residual Spraying in malaria vector control is threatened by vector resistance to insecticides. Knowledge of mosquito habitats and patterns of insecticide resistance would facilitate the development of appropriate vector control strategies. There...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-016-1542-y

    authors: Etang J,Mbida Mbida A,Ntonga Akono P,Binyang J,Eboumbou Moukoko CE,Lehman LG,Awono-Ambene P,Talipouo A,Ekoko Eyisab W,Tagne D,Tchoffo R,Manga L,Mimpfoundi R

    更新日期:2016-05-20 00:00:00

  • Significance of soluble triggering receptor expressed on myeloid cells-1 elevation in patients admitted to the intensive care unit with sepsis.

    abstract:BACKGROUND:Among septic patients admitted to the intensive care unit (ICU), early recognition of those with the highest risk of death is of paramount importance. Since clinical judgment is sometimes uncertain biomarkers could provide additional information likely to guide critical illness management. We evaluated the p...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-016-1893-4

    authors: Charles PE,Noel R,Massin F,Guy J,Bollaert PE,Quenot JP,Gibot S

    更新日期:2016-10-12 00:00:00

  • Paediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study of aseptic meningitis.

    abstract:BACKGROUND:The seasonality, clinical and radiographic features and outcome of aseptic meningitis have been described for regional outbreaks but data from a wider geographic area is necessary to delineate the epidemiology of this condition. METHODS:A retrospective chart review was completed of children presenting with ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-6-68

    authors: Lee BE,Chawla R,Langley JM,Forgie SE,Al-Hosni M,Baerg K,Husain E,Strong J,Robinson JL,Allen U,Law BJ,Dobson S,Davies HD

    更新日期:2006-04-10 00:00:00

  • Infection with high proportion of multidrug-resistant bacteria in conflict-related injuries is associated with poor outcomes and excess resource consumption: a cohort study of Syrian patients treated in Jordan.

    abstract:BACKGROUND:Armed conflicts are a major contributor to injury and death globally. Conflict-related injuries are associated with a high risk of wound infection, but it is unknown to what extent infection directly relates to sustainment of life and restoration of function. The aim of this study was to investigate the outc...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-3149-y

    authors: Älgå A,Wong S,Shoaib M,Lundgren K,Giske CG,von Schreeb J,Malmstedt J

    更新日期:2018-05-22 00:00:00

  • Impact of repeated four-monthly anthelmintic treatment on Plasmodium infection in preschool children: a double-blind placebo-controlled randomized trial.

    abstract:BACKGROUND:Helminth infections can alter susceptibility to malaria. Studies need to determine whether or not deworming programs can impact on Plasmodium infections in preschool children. METHODS:A double-blind placebo-controlled randomised trial was conducted to investigate the impact of anthelmintic treatment on Plas...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-2334-10-277

    authors: Kirwan P,Jackson AL,Asaolu SO,Molloy SF,Abiona TC,Bruce MC,Ranford-Cartwright L,O' Neill SM,Holland CV

    更新日期:2010-09-21 00:00:00

  • Determinants of survival of people living with HIV/AIDS on antiretroviral therapy in Brazil 2006-2015.

    abstract:BACKGROUND:We compared AIDS-related mortality rates in people living with HIV (PLHIV) starting antiretroviral therapy (ART) in Brazil during 2006-2015 and examined associated risk factors . METHODS:Data on ART use in PLHIV and AIDS mortality in Brazil was analysed with piecewise constant exponential models. Mortality ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-019-3844-3

    authors: Mangal TD,Meireles MV,Pascom ARP,de Almeida Coelho R,Benzaken AS,Hallett TB

    更新日期:2019-02-28 00:00:00

  • Acute osteomyelitis of the humerus mimicking malignancy: Streptococcus pneumoniae as exceptional pathogen in an immunocompetent adult.

    abstract:BACKGROUND:Chronic osteomyelitis due to direct bone trauma or vascular insufficiency is a frequent problem in orthopaedic surgery. In contrast, acute haematogenous osteomyelitis represents a rare entity that almost exclusively affects prepubescent children or immunodeficient adults. CASE PRESENTATION:In this article, ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-13-266

    authors: Prodinger PM,Pilge H,Banke IJ,Bürklein D,Gradinger R,Miethke T,Holzapfel BM

    更新日期:2013-06-05 00:00:00

  • Hospitalization for diseases attributable to human papillomavirus in the Veneto Region (North-East Italy).

    abstract:BACKGROUND:Human papillomavirus (HPV) is one of the most common sexually-transmitted pathogens. A number of studies in the literature have estimated the burden of HPV-related diseases by collecting data at primary care level, while a comprehensive assessment of the global burden of HPV-related diseases on hospital reso...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-13-462

    authors: Baldo V,Cocchio S,Buja A,Baldovin T,Furlan P,Bertoncello C,Saia M

    更新日期:2013-10-05 00:00:00

  • Male circumcision and prevalence of genital human papillomavirus infection in men: a multinational study.

    abstract:BACKGROUND:Accumulated evidence from epidemiological studies and more recently from randomized controlled trials suggests that male circumcision (MC) may substantially protect against genital HPV infection in men. The purpose of this study was to assess the association between MC and genital HPV infection in men in a l...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-13-18

    authors: Albero G,Villa LL,Lazcano-Ponce E,Fulp W,Papenfuss MR,Nyitray AG,Lu B,Castellsagué X,Abrahamsen M,Smith D,Bosch FX,Salmerón J,Quiterio M,Giuliano AR

    更新日期:2013-01-17 00:00:00

  • Burden of bacterial resistance among neonatal infections in low income countries: how convincing is the epidemiological evidence?

    abstract:BACKGROUND:Antibiotic resistance is a threat in developing countries (DCs) because of the high burden of bacterial disease and the presence of risk factors for its emergence and spread. This threat is of particular concern for neonates in DCs where over one-third of neonatal deaths may be attributable to severe infecti...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1186/s12879-015-0843-x

    authors: Huynh BT,Padget M,Garin B,Herindrainy P,Kermorvant-Duchemin E,Watier L,Guillemot D,Delarocque-Astagneau E

    更新日期:2015-03-15 00:00:00

  • Cutaneous leishmaniasis a neglected tropical disease: community knowledge, attitude and practices in an endemic area, Northwest Ethiopia.

    abstract:BACKGROUND:Cutaneous leishmaniasis is one of the neglected tropical diseases in the Ethiopian highlands and studies on assessment of knowledge, attitude and practice of the community in endemic areas are scanty. The study aimed to assess the knowledge, attitude towards cutaneous leishmaniasis and treatment seeking prac...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-019-4506-1

    authors: Tamiru HF,Mashalla YJ,Mohammed R,Tshweneagae GT

    更新日期:2019-10-16 00:00:00

  • Epidemiological and clinical features of human rabies cases in Bali 2008-2010.

    abstract:BACKGROUND:Previously thought to be rabies free, Bali experienced an outbreak of animal and human rabies cases in November 2008. We describe the epidemiological and clinical data of human rabies cases occurring in the first two years of the outbreak. METHODS:We analysed the patient records of all rabies cases from the...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-12-81

    authors: Susilawathi NM,Darwinata AE,Dwija IB,Budayanti NS,Wirasandhi GA,Subrata K,Susilarini NK,Sudewi RA,Wignall FS,Mahardika GN

    更新日期:2012-04-02 00:00:00

  • Triple valve endocarditis by mycobacterium tuberculosis: a case report.

    abstract:BACKGROUND:Granulomas caused by Mycobacterium Tuberculosis have been observed at autopsy in the heart, pre-dominantly in the myocardium and endocardium, but rarely involving the coronary vessels and valvular structures. Mycobacterium tuberculosis valvular endocarditis is extremely rare, with most reports coming from au...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-12-231

    authors: Shaikh Q,Mahmood F

    更新日期:2012-09-27 00:00:00

  • Retrospective analysis of acute HBV infections occurred in 1978-79 and 1994-95 in North-East Italy: increasing prevalence of BCP/pre-core mutants in sub-genotype D3.

    abstract:BACKGROUND:At the end of the 1970s, in Italy more than 2% of the general population was HBsAg carrier. In the late '70s and late '80s, two remarkable events might have impacted on HBV strains transmitted in North-East Italy: (a) the increased HBV incidence due to parenteral drugs between 1978 and 1982; (b) the preventi...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-019-4713-9

    authors: Bruni R,Villano U,Taffon S,Equestre M,Madonna E,Chionne P,Candido A,Dettori S,Pisani G,Rapicetta M,Bortolotti F,Ciccaglione AR

    更新日期:2020-01-28 00:00:00

  • Comparative efficacies of different antibiotic treatments to eradicate nontypeable Haemophilus influenzae infection.

    abstract:BACKGROUND:Nonencapsulated and nontypeable Haemophilus influenzae (NTHi) is a major cause of human respiratory tract infections. Some strains of NTHi can cause invasive diseases such as septicemia and meningitis, even if H. influenzae is not generally considered to be an intracellular pathogen. There have been very few...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-8-15

    authors: Sekiya Y,Eguchi M,Nakamura M,Ubukata K,Omura S,Matsui H

    更新日期:2008-02-07 00:00:00

  • Procalcitonin-guided algorithm to reduce length of antibiotic therapy in patients with severe sepsis and septic shock.

    abstract:BACKGROUND:Procalcitonin (PCT)-protocols to guide antibiotic treatment in severe infections are known to be effective. But less is known about the long-term effects of such protocols on antibiotic consumption under real life conditions. This retrospective study analyses the effects on antibiotic use in patients with se...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-13-158

    authors: Hohn A,Schroeder S,Gehrt A,Bernhardt K,Bein B,Wegscheider K,Hochreiter M

    更新日期:2013-04-01 00:00:00

  • Odontogenic cutaneous sinus tracts due to infection with nontuberculous mycobacteria: a report of three cases.

    abstract:BACKGROUND:Soft tissue or skin infections due to nontuberculous mycobacteria (NTM) have been reported frequently and are mostly associated with trauma or cosmetic interventions like plastic surgery. However, infection with NTM as a result of a dental procedure have rarely been described and the lack of clinical suspici...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-020-05015-5

    authors: Pérez-Alfonzo R,Poleo Brito LE,Vergara MS,Ruiz Damasco A,Meneses Rodríguez PL,Kannee Quintero CE,Carrera Martinez C,Rivera-Oliver IA,Da Mata Jardin OJ,Rodríguez-Castillo BA,de Waard JH

    更新日期:2020-04-21 00:00:00

  • Predictors of failure of conservative treatment among patients with emphysematous pyelonephritis.

    abstract:BACKGROUND:Emphysematous pyelonephritis (EPN) is a severe necrotizing infection of the renal parenchyma and perirenal tissues that is caused by gas-producing bacterial pathogens. Percutaneous drainage is now the gold standard of definitive management. The aim of this study is to analyze the predictors associated with f...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-14-418

    authors: Lu YC,Chiang BJ,Pong YH,Huang KH,Hsueh PR,Huang CY,Pu YS

    更新日期:2014-07-29 00:00:00

  • Detecting SARS-CoV-2 at point of care: preliminary data comparing loop-mediated isothermal amplification (LAMP) to polymerase chain reaction (PCR).

    abstract:BACKGROUND:A cost effective and efficient diagnostic tool for COVID-19 as near to the point of care (PoC) as possible would be a game changer in the current pandemic. We tested reverse transcription loop mediated isothermal amplification (RT-LAMP), a method which can produce results in under 30 min, alongside standard ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-020-05484-8

    authors: Österdahl MF,Lee KA,Lochlainn MN,Wilson S,Douthwaite S,Horsfall R,Sheedy A,Goldenberg SD,Stanley CJ,Spector TD,Steves CJ

    更新日期:2020-10-20 00:00:00

  • HBV reactivation in an occult HBV infection patient treated with prednisone for nephrotic syndrome: case report and literature review.

    abstract:BACKGROUND:Reactivation of hepatitis B virus (HBV), characterized by increased levels of serum HBV DNA, abnormal liver function and hepatic failure, is a frequent complication of immunosuppressive therapy and chemotherapy in patients with HBV infection. However, reactivation of occult HBV infection with immunosuppressi...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-13-394

    authors: Du W,Zheng Z,Han S,Ma S,Chen S

    更新日期:2013-08-27 00:00:00

  • The diagnostic accuracy of direct agglutination test for serodiagnosis of human visceral leishmaniasis: a systematic review with meta-analysis.

    abstract:BACKGROUND:Direct agglutination test (DAT) as a simple, accurate and reliable method, has been widely used for serodiagnosis of visceral leishmaniasis (VL) during the last three decades. The present study is a systematic review and meta-analysis to evaluate the diagnostic accuracy of DAT for serodiagnosis of human VL. ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12879-020-05558-7

    authors: Mohebali M,Keshavarz H,Shirmohammad S,Akhoundi B,Borjian A,Hassanpour G,Mamishi S,Mahmoudi S

    更新日期:2020-12-11 00:00:00

  • Effectiveness of DNA-recombinant anti-hepatitis B vaccines in blood donors: a cohort study.

    abstract:BACKGROUND:Although various studies have demonstrated efficacy of DNA-recombinant anti-hepatitis B vaccines, their effectiveness in health care settings has not been researched adequately. This gap is particularly visible for blood donors, a group of significant importance in the reduction of transfusion-transmitted he...

    journal_title:BMC infectious diseases

    pub_type: 临床试验,杂志文章

    doi:10.1186/1471-2334-7-124

    authors: Kupek E,de Souza DE,Petry A

    更新日期:2007-11-06 00:00:00

  • Risk factors for acute respiratory tract infections in general practitioner patients in The Netherlands: a case-control study.

    abstract:BACKGROUND:Acute respiratory tract infections (ARTI) are an important public health problem. Improved identification of risk factors might enable targeted intervention. Therefore we carried out a case-control study with the aim of identifying environmental risk factors for ARTI consultations in the Dutch general popula...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-7-35

    authors: van Gageldonk-Lafeber AB,van der Sande MA,Heijnen ML,Peeters MF,Bartelds AI,Wilbrink B

    更新日期:2007-04-27 00:00:00