Metabolic transition in the development of Hymenolepis diminuta (Cestoda).

Abstract:

:Cysticercoids as well as 6-, 10-, and 14-day Hymenolepis diminuta were evaluated in terms of enzymatic activities related to phosphoenolpyruvate (PEP) utilization and mitochondrial succinate accumulation. The data obtained support a transition toward anaerobic electron-transport-dependent succinate accumulation, characteristic of adult H. diminuta, with development from cysticercoid to adult. This transition was reflected most prominently in the increasing activities of PEP carboxykinase (PEPCK), malate dehydrogenase, NADPH-->NAD+ transhydrogenase, and fumarate reductase. Developmental increases in PEPCK/pyruvate kinase (PK), fumarate reductase (FR)/NADH oxidase (NO), and FR/succinate dehydrogenase (SDH) activity ratios were also apparent. Evaluations of "egg-free" immature, mature, and pregravid-gravid segments of adult H. diminuta revealed that in general the greater levels of activity were associated with the immature and mature segments. Whereas FR/NO and FR/SDH ratios remained relatively constant in segment comparisons, the greatest PEPCK/PK ratio was associated with the pregravid-gravid segment.

journal_name

Parasitol Res

journal_title

Parasitology research

authors

Fioravanti CF,Walker DJ,Sandhu PS

doi

10.1007/s004360050487

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

777-82

issue

10

eissn

0932-0113

issn

1432-1955

journal_volume

84

pub_type

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