Invasion of Rh Null Cells by Plasmodium falciparum identifies a new invasion pathway.

Abstract:

:The malaria parasite, Plasmodium falciparum, invades the human erythrocyte through a complex interaction with erythrocyte receptors characterized by patterns of resistance to various enzymes. As invasion rates are influenced by blood group polymorphisms, we reasoned that the extremely rare rhesus null (Rh(null)) erythrocytes could be informative in characterizing receptors. The aim was to test whether the complete absence of the Rh complex from the cell membrane impacted on parasite invasion. Enzyme treatment patterns for four P. falciparum isolates were first characterised for normal Rh cells. Two isolates showed an enzyme treatment pattern not hitherto described, with resistance to neuraminidase, trypsin and chymotrypsin. In contrast, all isolates had enhanced invasion rates for the Rh(null) cell for all enzyme treatment regimens. The first finding suggests there is another pathway that P. falciparum can utilise to invade the host. We speculate that the Rh null cell membrane exposes a novel ligand defined as Receptor N.

journal_name

Parasitol Res

journal_title

Parasitology research

authors

Chung WY,Gardiner DL,Hyland C,Trenholme KR

doi

10.1007/s00436-007-0756-8

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

259-63

issue

2

eissn

0932-0113

issn

1432-1955

journal_volume

102

pub_type

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