Abstract:
:The malaria parasite, Plasmodium falciparum, invades the human erythrocyte through a complex interaction with erythrocyte receptors characterized by patterns of resistance to various enzymes. As invasion rates are influenced by blood group polymorphisms, we reasoned that the extremely rare rhesus null (Rh(null)) erythrocytes could be informative in characterizing receptors. The aim was to test whether the complete absence of the Rh complex from the cell membrane impacted on parasite invasion. Enzyme treatment patterns for four P. falciparum isolates were first characterised for normal Rh cells. Two isolates showed an enzyme treatment pattern not hitherto described, with resistance to neuraminidase, trypsin and chymotrypsin. In contrast, all isolates had enhanced invasion rates for the Rh(null) cell for all enzyme treatment regimens. The first finding suggests there is another pathway that P. falciparum can utilise to invade the host. We speculate that the Rh null cell membrane exposes a novel ligand defined as Receptor N.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Chung WY,Gardiner DL,Hyland C,Trenholme KRdoi
10.1007/s00436-007-0756-8subject
Has Abstractpub_date
2008-01-01 00:00:00pages
259-63issue
2eissn
0932-0113issn
1432-1955journal_volume
102pub_type
杂志文章abstract::During a survey lasting from 1990 to 2008, we captured 4,113 Asian house rats, Rattus tanezumi Temminck 1844 (Rodentia: Muridae) from 28 counties of Yunnan Province in southwestern China. From these rats, a total of 19,304 gamasid mites (Acari: Mesostigmata) were collected and identified as comprising 50 different spe...
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doi:10.1007/s00436-013-3354-y
更新日期:2013-05-01 00:00:00
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journal_title:Parasitology research
pub_type: 杂志文章
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pub_type: 更正并重新发布的文章,杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2010-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s004360050568
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