A marker epitope of attenuated Plasmodium berghei.

Abstract:

:Plasmodium berghei XAT is an irradiation-induced, permanent attenuated derivative from high-virulence P. berghei NK65. Monoclonal antibodies against XAT were developed. By immunofluorescence screening, one monoclonal antibody was identified that was reactive with XAT at the schizont stage but not with NK65 nor with any other stage of intra-erythrocytic development of either parasite. The monoclonal antibody precipitated a 240-kD molecule from metabolically labeled XAT antigens. This molecule was thought to be a marker epitope of the attenuated parasite.

journal_name

Parasitol Res

journal_title

Parasitology research

authors

Takagi T,Waki S,Kogure S,Sugioka Y,Suzuki M

doi

10.1007/BF00535143

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

436-40

issue

5

eissn

0932-0113

issn

1432-1955

journal_volume

74

pub_type

杂志文章