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A humanized monoclonal antibody produced in transgenic plants for immunoprotection of the vagina against genital herpes.

Abstract：

:The ability to produce monoclonal antibodies (Mabs) in plants offers the opportunity for the development of an inexpensive method of mucosal immunoprotection against sexually transmitted diseases. To investigate the suitability of plant-expressed Mabs for vaginal preventive applications, we compared a humanized anti-herpes simplex virus 2 (HSV-2) Mab expressed in mammalian cell culture with the same antibody expressed in soybean. We found these Mabs to be similar in their stability in human semen and cervical mucus over 24 h, their ability to diffuse in human cervical mucus, and their efficacy for prevention of vaginal HSV-2 infection in the mouse.

journal_name

Nat Biotechnol

journal_title

Nature biotechnology

authors

Zeitlin L,Olmsted SS,Moench TR,Co MS,Martinell BJ,Paradkar VM,Russell DR,Queen C,Cone RA,Whaley KJ

doi

10.1038/4344

subject

Has Abstract

pub_date

1998-12-01 00:00:00

pages

1361-4

issue

13

eissn

1087-0156

issn

1546-1696

journal_volume

16

pub_type

杂志文章

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