Abstract:
:The RCR of malate+glutamate oxidation of isolated rat brain mitochondria decreased with increasing duration of anoxia and it ceased completely in the 12 hour ischemic group. After one hour of ischemic anoxia neither the respiration of mitochondria nor their morphology altered irreversibly. There is a strong correlation between the ultrastructural changes and RCR value of mitochondria, namely the RCR decreased proportionally with increasing number of light type of mitochondria. From our results we can conclude that the dense form seems to be the functional form, while the light mitochondrial structure is a transition to the non functioning homogenous type of brain mitochondria.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Ikrényi K,Dóra E,Hajós F,Kovách AGdoi
10.1007/978-1-4684-3273-2_20subject
Has Abstractpub_date
1976-01-01 00:00:00pages
159-64eissn
0065-2598issn
2214-8019journal_volume
75pub_type
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