Noncoding RNAs Regulating Cancer Signaling Network.

abstract：:Direct studies linking drugs of abuse with changes in neurotransmitters and subsequent effects on the immune system are not abundant. One can, however, hypothesize that an indirect effect can occur since a variety of neurotransmitters known to be acted on by various drugs of abuse can, in turn, be correlated with chan...

journal_title：Advances in experimental medicine and biology

authors： Hall NR,O'Grady MP,Menzies RA

更新日期：1991-01-01 00:00:00

abstract：:All previous studies on the yeast metabolome have yielded a plethora of information on the components, function and organisation of low molecular mass and macromolecular components involved in the cellular metabolic network. Here we emphasise that an understanding of the global dynamics of the metabolome in vivo requi...

journal_title：Advances in experimental medicine and biology

authors： Sasidharan K,Tomita M,Aon M,Lloyd D,Murray DB

更新日期：2012-01-01 00:00:00

abstract：:The cholesterol-dependent cytolysins (CDCs) are part of a large family of pore-forming proteins that include the human proteins perforin and the complement membrane attack complex. The activity of all family members is focused on membranes, but the proteins are themselves involved in a diverse range of phenomena. An o...

journal_title：Advances in experimental medicine and biology

authors： Gilbert RJ

更新日期：2010-01-01 00:00:00

abstract：:The effects of exposure to continuous and intermittent anthropogenic sounds on temporary hearing threshold shifts (TTSs) in a harbor porpoise were investigated by testing hearing before and after exposure to 1- to 2-kHz downsweeps of 1 s, without harmonics, presented as paired-intermittent and continuous-exposure comb...

journal_title：Advances in experimental medicine and biology

authors： Kastelein RA,Gransier R,Hoek L

更新日期：2016-01-01 00:00:00

abstract：:The development and validation of scientific alternatives to animal testing is important not only from an ethical perspective (implementation of 3Rs), but also to improve safety assessment decision making with the use of mechanistic information of higher relevance to humans. To be effective in these efforts, it is how...

journal_title：Advances in experimental medicine and biology

authors： Barroso J,Ahn IY,Caldeira C,Carmichael PL,Casey W,Coecke S,Curren R,Desprez B,Eskes C,Griesinger C,Guo J,Hill E,Roi AJ,Kojima H,Li J,Lim CH,Moura W,Nishikawa A,Park H,Peng S,Presgrave O,Singer T,Sohn SJ,West

更新日期：2016-01-01 00:00:00

abstract：:Malignant epithelial tumors of the upper digestive tract are a major cause of cancer-related death worldwide. The most common of these cancers are head and neck squamous cell carcinomas (HNSCC) and esophageal cancers (EC), which are both characterized by early dissemination and poor prognosis. Although patients with e...

journal_title：Advances in experimental medicine and biology

authors： Sproll C,Fluegen G,Stoecklein NH

更新日期：2018-01-01 00:00:00

abstract：:We report that rat RT6.2 and recombinant mouse Rt6 locus 1 proteins possess auto-ADP-ribosyltransferase activity and that Rt6, but not RT6, catalyzes the ADP-ribosylation of exogenous histones. Based on NH2OH sensitivity, it appeared that the ADP-ribose was attached to arginine residues on proteins. We also observed t...

journal_title：Advances in experimental medicine and biology

authors： Bortell R,Rigby M,Stevens L,Moss J,Kanaitsuka T,Mordes J,Greiner D,Rossini A

更新日期：1997-01-01 00:00:00

abstract：:From the time of the Hong Kong pandemic of 1968-1969, vaccines against influenza are trivalent, containing two subtypes of influenza type A: A/H1N1/ and A/H3N2/, and influenza type B. In 1980, circulation of the new Yamagata and Victoria lineages of influenza B virus was noted. Since both lineages have continued to ci...

journal_title：Advances in experimental medicine and biology

authors： Bednarska K,Hallmann-Szelińska E,Kondratiuk K,Rabczenko D,Brydak LB

更新日期：2016-01-01 00:00:00

abstract：:Post-natal skeletal muscle is a highly plastic tissue that has the capacity to regenerate rapidly following injury, and to undergo significant modification in tissue mass (i.e. atrophy/hypertrophy) in response to global metabolic changes. These processes are reliant largely on soluble factors that directly modulate mu...

journal_title：Advances in experimental medicine and biology

authors： Smythe G

更新日期：2016-01-01 00:00:00

abstract：:Curcumin, a major active component of turmeric, is extracted from the powdered dry rhizome of Curcuma longa Linn (Zingiberaceae) and it has been used for centuries in indigenous medicine. We have shown that curcumin has a protective role against myocardial necrosis in rats. The antioxidant activity of curcumin could b...

journal_title：Advances in experimental medicine and biology

authors： Miriyala S,Panchatcharam M,Rengarajulu P

更新日期：2007-01-01 00:00:00

abstract：:Klebsiella pneumoniae is one of the most important hospital pathogens, particularly concerning the multidrug-resistant strain ESBL+. The aim of this study was to evaluate nosocomial infections with K. pneumoniae ESBL+ in the context of infection location, risk factors, and prognosis. This hospital study was conducted ...

journal_title：Advances in experimental medicine and biology

authors： Starzyk-Łuszcz K,Zielonka TM,Jakubik J,Życińska K

更新日期：2017-01-01 00:00:00

abstract：:More than one billion years ago, mitochondria were free-living prokaryotic organisms with their own DNA. However, during the evolution, ancestral genes have been transferred from the mitochondrial to the nuclear genome so that mtDNA became dependent on numerous nucleus-encoded factors for its integrity, replication an...

journal_title：Advances in experimental medicine and biology

authors： Spinazzola A,Zeviani M

更新日期：2009-01-01 00:00:00

abstract：:Cerebral infarction (CI) caused by middle cerebral artery occlusion exhibits a very high mortality rate. To reduce this rate, a decompressive hemicraniectomy (DHC) is performed clinically based on several randomized trials. In ischemic stroke, a state of malnutrition leads to poor outcomes. However, little evidence is...

journal_title：Advances in experimental medicine and biology

authors： Kutsuna N,Makita K,Goto K,Hirayama K,Kido G,Kagawa Y

更新日期：2018-01-01 00:00:00

abstract：:The effects of imprinted genes on fetal growth and development have been firmly established. By and large, their roles conform to a conflict over provision of limited maternal resources to offspring, such that paternally expressed imprinted genes in offspring generally promote growth of the fetus, while maternally exp...

journal_title：Advances in experimental medicine and biology

authors： Frontera M,Dickins B,Plagge A,Kelsey G

更新日期：2008-01-01 00:00:00

abstract：:Cutaneous receptors in the foot sole appear to contribute to the control of human stance and locomotion. Two approaches were undertaken to establish the characteristics of the receptors in the sole. Psychophysical vibrotactile thresholds (range 25-400 Hz) were determined across the unloaded sole in young and elderly s...

journal_title：Advances in experimental medicine and biology

authors： Inglis JT,Kennedy PM,Wells C,Chua R

更新日期：2002-01-01 00:00:00

abstract：:Necrotizing soft tissue infections (NSTI) are multifactorial and characterized by dysfunctional, time dependent, highly varying hyper- to hypo-inflammatory host responses contributing to disease severity. Furthermore, host-pathogen interactions are diverse and difficult to identify and characterize, due to the many di...

journal_title：Advances in experimental medicine and biology

authors： Martins Dos Santos VAP,Hardt C,Skrede S,Saccenti E

更新日期：2020-01-01 00:00:00

abstract：:We identified a 45 kDa Ca(2+)-dependent Lf binding protein on rat hepatocytes. Dithiobis(sulfosuccimidylproprionate) (DTSSP)-crosslinked 125I-Lf to a 45 kDa adduct in a Ca(2+)-dependent manner on intact cells. The 125I-labeled crosslinked complexes were absent when either surface-bound 125I-Lf was stripped prior to cr...

journal_title：Advances in experimental medicine and biology

authors： McAbee DD,Bennatt DJ,Ling YY

更新日期：1998-01-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) is an established clinical technique that measures diffusion-weighted signals, applied primarily in brain studies. Diffusion tensor imaging (DTI) is a technique that uses the diffusion-weighted signals to obtain information about tissue connectivity, which recently started to become es...

journal_title：Advances in experimental medicine and biology

authors： Delibasis Κ,Aronis C,Fanariotis M,Maglogiannis I

更新日期：2020-01-01 00:00:00

abstract：:Ventricular fibrillation is the major underlying cause of sudden cardiac death. Understanding the complex activation patterns that give rise to ventricular fibrillation requires high resolution mapping of localized activation. The use of multi-electrode mapping unraveled re-entrant activation patterns that underlie ve...

journal_title：Advances in experimental medicine and biology

authors： Boukens BJ,Gutbrod SR,Efimov IR

更新日期：2015-01-01 00:00:00

abstract：:Identification of thyroid stem cells in the past few years has made important contributions to our understanding of the cellular and molecular mechanisms that induce tissue regeneration and repair. Embryonic stem (ES) cells and induced-pluripotent stem cells have been used to establish reliable protocols to obtain mat...

journal_title：Advances in experimental medicine and biology

authors： Zito G,Coppola A,Pizzolanti G,Giordano C

更新日期：2019-01-01 00:00:00

abstract：:Recent studies emphasize the role of chronic hypoxia in the kidney as a final common pathway to end-stage renal disease (ESRD). Hypoxia of tubular cells leads to apoptosis or epithelial-mesenchymal transdifferentiation. This in turn exacerbates fibrosis of the kidney with loss of peritubular capillaries and subsequent...

journal_title：Advances in experimental medicine and biology

authors： Nangaku M,Inagi R,Miyata T,Fujita T

更新日期：2007-01-01 00:00:00

abstract：:The mammalian thioredoxins are a family of small redox proteins that undergo NADPH dependent reduction by thioredoxin reductase. Reduced thioredoxins reduce oxidized cysteine groups on proteins including transcription factors to increase their binding to DNA, and is a source of reducing equivalents for enzymes such as...

journal_title：Advances in experimental medicine and biology

authors： Husbeck B,Berggren MI,Powis G

更新日期：2001-01-01 00:00:00

abstract：:Hypertension increases the risks of end-organ injury, maternal/fetal vulnerability, and total mortality. Throughout the world, it kills about 7.5 million people every year. During 1975-2015, the number of adults with hypertension increased from 594 million to more than 1.1 billion, mostly due to the increase in the lo...

journal_title：Advances in experimental medicine and biology

authors： Islam MS

更新日期：2017-01-01 00:00:00

abstract：:Stem cells provide for all of the tissues in our body during embryogenesis. In adult organisms, they can be found as rare populations of tissue-specific stem cells in quiescent states, although they can still regenerate damaged tissues. Astonishingly, these cells are retained in tissues even post-mortem. There have be...

journal_title：Advances in experimental medicine and biology

authors： Haring G,Zupan J

更新日期：2020-01-01 00:00:00

abstract：:The activity of liver macrophages was evaluated using a magnetometric method after administration of different perfluorochemicals. Following treatment with perfluoroctylbromide a significant shorter time period of diminished macrophage activity was found compared with a mixture of perfluorodecalin and perfluorotriprop...

journal_title：Advances in experimental medicine and biology

authors： Koester MB,Lutz J

更新日期：1994-01-01 00:00:00

abstract：:Women lose bone during lactation, and this is an important mechanism to provide calcium for human milk. Bone loss during lactation occurs even in women with high calcium intakes. Lactation-induced bone loss is transient because bone density increases rapidly after weaning. Bone loss during lactation and recovery after...

journal_title：Advances in experimental medicine and biology

authors： Kalkwarf HJ

更新日期：2004-01-01 00:00:00

abstract：:Retinoids clearly show both prophylactic and therapeutic effects against many kinds of neoplasm. Vitamin A deficiency and vitamin A excess, which are very different states clinically and metabolically, should be separately considered relative to carcinogenesis. The anticancer effects of retinoids and related compounds...

journal_title：Advances in experimental medicine and biology

authors： Olson JA

更新日期：1986-01-01 00:00:00

abstract：:Odontocete cetaceans are acoustic specialists that depend on sound to hunt, forage, navigate, detect predators, and communicate. Auditory masking from natural and anthropogenic sound sources may adversely affect these fitness-related capabilities. The ability to detect a tone in a broad range of natural, anthropogenic...

journal_title：Advances in experimental medicine and biology

authors： Branstetter BK,Bakhtiari KL,Trickey JS,Finneran JJ

更新日期：2016-01-01 00:00:00

abstract：:Immunological effector cells and molecules have been shown to access intracranial tumor sites despite the existence of blood brain barrier (BBB) or immunosuppressive mechanisms associated with brain tumors. Recent progress in T-cell biology and tumor immunology made possible to develop strategies of tumor-associated a...

journal_title：Advances in experimental medicine and biology

authors： Ikeda H,Shiku H

更新日期：2012-01-01 00:00:00

abstract：:Sonodynamic therapy (SDT) represents an emerging approach that offers the possibility of non-invasively eradicating solid tumors in a site-directed manner. It involves the sensitization of target tissues with a non-toxic sensitizing chemical agent and subsequent exposure of the sensitized tissues to relatively low-int...

journal_title：Advances in experimental medicine and biology

authors： McHale AP,Callan JF,Nomikou N,Fowley C,Callan B

更新日期：2016-01-01 00:00:00