Abstract：
:The transparency of the eye can be disturbed by several eye diseases. It has recently been reported that periostin plays pivotal roles in the pathogenesis of several eye disease, such as diabetic retinopathy (DR), age-related macular degeneration (AMD), glaucoma, pterygia, corneal dystrophy, and chronic ocular allergic diseases. In these diseases, formation of fibro (vascular) tissue plays an important role. Gene expression profiling of human retinal fibro (vascular) membrane revealed significant up-regulation of periostin. The expression of periostin after environmental perturbations, including IL-4 and/or IL-13 induction, can alter normal physiological interactions among fibroblasts, macrophages and ECM protein in the eye. Modulating the expression of periostin by low-molecular weight compounds, antibodies or RNAi directed against the molecule could be a novel therapeutic strategy for inhibiting the progression of those periostin-involved eye diseases.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Yoshida S,Umeno Y,Haruta Mdoi
10.1007/978-981-13-6657-4_12subject
Has Abstractpub_date
2019-01-01 00:00:00pages
113-124eissn
0065-2598issn
2214-8019journal_volume
1132pub_type
杂志文章,评审abstract：:The relation of transcutaneous pO2 (tcpO2) and cutaneous blood flow (CBF) was measured on the forearm of 19 healthy volunteers by use of a tcpO2 electrode heated to 45 degrees C. CBF was estimated indirectly from the heating power of the electrode (HP) and with a 8 MHz bidirectional ultrasonic probe by Doppler shift i...
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更新日期：2016-01-01 00:00:00
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