Abstract：
:The epithelial cells of the gastrointestinal tract from different species show a very variable expression of blood group active glycosphingolipids. The core saccharide sequences are typical for the species as, for example, type 1 chains (Gal beta 1----3GlcNAc) are found in the small intestine of man, rat, and pig and type 2 chains (Gal beta 1----4GlcNAc) are found in the small intestine of dog, rabbit, and cat. The mouse is atypical with the ganglioseries as the major core saccharide of the small intestine. Blood group A determinants can be found in the small intestine of man, rat, dog, rabbit, and cat, and the blood group B determinant in man and rabbit. Studies on the blood group active glycosphingolipids along the gastrointestinal tract of rat have revealed a complex distribution. The glandular cells of the stomach and epithelial cells of the large intestine express blood group B active glycosphingolipids. The cores of these are the ganglioseries, and the isogloboseries in the stomach and the lacto- (type 1) and neolactoseries (type 2) in the large intestine. The type 2 component is only expressed as a difucosyl and the type 1 as a monofucosyl compound. The epithelial cells of the small intestine are devoid of blood group B glycolipids, but express blood group H structures of which some has a branched core saccharide. One rat strain is lacking blood group A structures in the small intestine, but another is converting the H precursors to blood group A compounds. Both these strains always express blood group A structures in the large intestine. The expression of blood group A glycosphingolipids in the small intestine is inherited as a dominant trait.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Hansson GCdoi
10.1007/978-1-4613-1663-3_17subject
Has Abstractpub_date
1988-01-01 00:00:00pages
465-94eissn
0065-2598issn
2214-8019journal_volume
228pub_type
杂志文章,评审abstract：:Autophagy is an endogenous and essential process which maintains cellular homeostasis and directs cell fate. The glomerular diseases are one main part of the kidney diseases, often associated with poor clinical outcomes. The regulation of autophagy contributes to the progression of various glomerular diseases, includi...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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journal_title：Advances in experimental medicine and biology
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pub_type： 杂志文章
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
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doi：10.1007/978-1-4615-1891-4_18
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pub_type： 杂志文章
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