Abstract：
:12-lipoxygenase (12-LOX) expression and function in the regulation of the metastatic phenotype was demonstrated in several murine melanoma lines before. Here we have provided novel evidences that, though at a low level (in max. 15% of the cell population), human melanoma lines (HT168, M1, HT199, HT18 and WM35) express the platelet-type isoform of 12-LOX both at mRNA and protein levels. 12-LOX expression was demonstrated in cultured tumor cells and in skin tumor xenografts. Comparison of the expression of 12-LOX in skin primary tumors and its lung metastases indicated a stable expression. The low level of 12-LOX expression in human melanoma cell lines suggests that other lipoxygenase(s) could also be responsible for the metabolism of arachidonic acid to 12-HETE breakdown products.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Timár J,Rásó E,Honn KV,Hagmann Wdoi
10.1007/978-1-4615-4793-8_89subject
Has Abstractpub_date
1999-01-01 00:00:00pages
617-22eissn
0065-2598issn
2214-8019journal_volume
469pub_type
杂志文章abstract：:Chronic lymphocytic leukemia (CLL) is the most frequently diagnosed leukemia in the Western world, yet remains essentially incurable. Although initial chemotherapy response rates are high, patients invariably relapse and subsequently develop resistance to chemotherapy. For the moment, allogeneic hematopoietic stem cel...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4614-8051-8_11
更新日期：2013-01-01 00:00:00
abstract：:The heart continuously supplies blood to the entire body throughout the lifetime, requiring a huge amount of the bioenergy molecule adenosine triphosphate (ATP). As the major subcellular organs that produce ATP through oxidative phosphorylation and the citrate-synthesis cycle, mitochondria inevitably produce chemicall...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-319-55330-6_32
更新日期：2017-01-01 00:00:00
abstract：:Extracellular free sodium (Na+)o and calcium (Ca2+)o concentration changes were measured in the rat motor cortex, using ion-selective microelectrodes. During ionophoretic applications of excitatory amino acids, decreases in (Na2+)o and in (Ca2+)o were observed. Ca2+ signals were not or very little modified by applicat...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4684-7971-3_33
更新日期：1986-01-01 00:00:00
abstract：:The chemical and enzymatic browning reactions of plant polyphenols and their effects on amino acids and proteins are reviewed. A model system of casein and oxidizing caffeic acid has been studied in more detail. The effects of pH, time, caffeic acid level and the presence or not of tyrosinase on the decrease of FDNB-r...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4684-4790-3_20
更新日期：1984-01-01 00:00:00
abstract：:The 1st International Conference on Oral Mucosal Immunity and the Microbiome (OMIM) took place at the Avra Imperial Hotel, Chania, Crete, Greece, between 26th and 30th September 2018, under the auspices of the Aegean Conferences. This was the first Aegean Conference of its kind in thematic oral research, and a unique ...
journal_title：Advances in experimental medicine and biology
pub_type：
doi：10.1007/978-3-030-28524-1_1
更新日期：2019-01-01 00:00:00
abstract：:Hypertension increases the risks of end-organ injury, maternal/fetal vulnerability, and total mortality. Throughout the world, it kills about 7.5 million people every year. During 1975-2015, the number of adults with hypertension increased from 594 million to more than 1.1 billion, mostly due to the increase in the lo...
journal_title：Advances in experimental medicine and biology
pub_type：
doi：10.1007/5584_2017_30
更新日期：2017-01-01 00:00:00
abstract：:While performing their functions, biological macromolecules often form large, dynamically changing macromolecular assemblies. Only a relatively small number of such assemblies have been accessible to the atomic-resolution techniques X-ray crystallography and NMR. Electron microscopy in conjunction with image reconstru...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-3-319-02970-2_6
更新日期：2014-01-01 00:00:00
abstract：:De novo synthesis of RNA sequences corresponding to intervening as well as to structural sequences of the ovalbumin gene have been detected in isolated oviduct nuclei. Their presence in the nuclear transcripts and their time course of induction support the hypothesis that transcription of structural and intervening se...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4757-6589-2_25
更新日期：1979-01-01 00:00:00
abstract：:In the modern era of next-generation genomics and Fourth Industrial Revolution, there is a growing demand for translational research that brings about not only impactful research but also potential commercialisation of R- and D-based products. Advancement of metabolic engineering and synthetic biology has put forward ...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-319-98758-3_6
更新日期：2018-01-01 00:00:00
abstract：:In this review, an overview of the host's innate immune response against Mycobacterium tuberculosis will be provided. In particular, M. tuberculosis interaction with Toll-like receptors (TLRs), lung surfactant proteins and the antimicrobial mechanisms in the macrophage will be discussed along with their importance in ...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4419-0901-5_13
更新日期：2009-01-01 00:00:00
abstract：:Collagen type I is the most abundant matrix protein in the human body and is highly demanded in tissue engineering, regenerative medicine, and pharmaceutical applications. To meet the uprising demand in biomedical applications, collagen type I has been isolated from mammalians (bovine, porcine, goat and rat) and non-m...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-981-13-0947-2_21
更新日期：2018-01-01 00:00:00
abstract：:The effect of hypoxia on the in vivo radiation response of tumors is demonstrated both for the measurement of cell survival and growth delay following treatment. Results using these endpoints for the KHT Sarcoma are then presented to demonstrate the effect of various parameters which are expected to control tumor oxyg...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4684-7790-0_3
更新日期：1983-01-01 00:00:00
abstract：:This chapter represents a novel view of modeling in hematopoiesis, synthesizing both deterministic and stochastic approaches. Whereas the stochastic models work in situations where chance dominates, for example when the number of cells is small, or under random mutations, the deterministic models are more important fo...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4939-2095-2_7
更新日期：2014-01-01 00:00:00
abstract：:Whilst the primary DNA sequence sets the limits of potential gene expression, the pattern of gene expression in a given cell under particular circumstances is determined by several factors including the epigenetic marking of the genome. These marks include DNA methylation and post-translational modification of the his...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4020-9173-5_13
更新日期：2009-01-01 00:00:00
abstract：:The analysis of complex biological networks has traditionally relied on decomposition into smaller, semi-autonomous units such as individual signaling pathways. With the increased scope of systems biology (models), rational approaches to modularization have become an important topic. With increasing acceptance of de f...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4419-7210-1_1
更新日期：2012-01-01 00:00:00
abstract：:This chapter will describe infectious complications of atopic dermatitis, including bacterial, viral, and fungal infections and the evolving understanding of the relationship between atopic dermatitis and infectious disease. The underlying immunological dysregulation and poor skin barrier function associated with atop...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-319-64804-0_5
更新日期：2017-01-01 00:00:00
abstract：:The International Society on Oxygen Transport to Tissue (ISOTT) was founded in April, 1973 by Drs. Duane F. Bruley and Haim I. Bicher. Dr. Bruley first wanted to sponsor an international symposium on oxygen transport to tissue to highlight the research activity between his group at Clemson University in Clemson, South...
journal_title：Advances in experimental medicine and biology
pub_type： 历史文章,杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:To investigate age-related changes in the shape of trachea, normal male volunteers (n = 83, mean +/- SD: 47.7 +/- 20.2 years old) underwent inspiratory CT scans at full inspiration and lung function tests. Subjects who showed VC < 80% predicted or FEV1 < 80% predicted on lung function tests were excluded. The CT data,...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4419-1241-1_16
更新日期：2010-01-01 00:00:00
abstract：:Circular RNAs (circRNAs) are widely present and participate in a variety of biological regulatory activities as a novel type of endogenous noncoding RNA molecule. With advances in RNA structure and function analysis, it was found that circRNAs are present in a myriad of life processes and longevity in model organisms ...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-981-13-1117-8_2
更新日期：2018-01-01 00:00:00
abstract：:Psychological therapies in order to provide cognitive enhancement have gained some momentum the last decades. The goal of this case study was to evaluate the effects of a cognitive enhancement training program on daily living activities, cognition, and depression in a demented elderly participant. A 6-month training p...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-3-319-57379-3_9
更新日期：2017-01-01 00:00:00
abstract：:CEP290 mutations cause a spectrum of ciliopathies, including Leber congenital amaurosis. Milder retinal diseases have been ascribed to exclusion of CEP290 mutant exons through basal exon skipping (BES) and/or nonsense-associated altered splicing (NAS). Here, we report two siblings with some preserved vision despite bi...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-3-030-27378-1_31
更新日期：2019-01-01 00:00:00
abstract：:The respiratory network is sensitive to both chemical and mechanosensory feedback and exhibits considerable plasticity when exposed to repeated respiratory perturbations. One example of respiratory plasticity is long-term facilitation (LTF) - a long-term enhancement in respiratory activity induced by intermittent hypo...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4419-5692-7_61
更新日期：2010-01-01 00:00:00
abstract：:Three experiments were conducted for the present study. First, to elucidate the mechanism and functional significance underlying ischemic vasoconstriction, we investigated the relationship between arteriolar constriction and tissue energy metabolism during bilateral common carotid artery occlusion in gerbils. Second, ...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4939-0620-8_33
更新日期：2014-01-01 00:00:00
abstract：:Administration of clenbuterol to rats in the drinking water over a four day period increased incorporation of [3H]leucine into muscle protein but did not result in an increase in body or muscle weight. However, both urinary and liver taurine were significantly reduced at the highest dose of clenbuterol (2 mg.kg-1.day-...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4899-0182-8_25
更新日期：1996-01-01 00:00:00
abstract：:Intravascular ultrasound (IVUS) is a new technique of tomographic visualization of the coronary arteries: its lumen, wall and pathology. Three dimensional (3D) reconstruction shows the tubular structure of the arterial wall and its pathology. IVUS has many advantages over coronary angiography: it has better resolution...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4615-5959-7_17
更新日期：1997-01-01 00:00:00
abstract：:Erdosteine as a mucolytic agent that decreases mucus viscosity and facilitates mucus expulsion from the airways by cough or ciliary movement. Our objective was to determine whether erdosteine can directly contribute to mucus clearance. We addressed the issue by monitoring acute and chronic effects of erdosteine on cil...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/5584_2017_48
更新日期：2018-01-01 00:00:00
abstract：:Coronary blood flow depends upon the vascular resistance distributed non-uniformly within the coronary microcirculation. Coronary microvascular resistance is governed by metabolic, myogenic, endothelial and neurohumoral influences. A number of these control mechanisms interact locally within a microvascular segment. I...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4615-2946-0_17
更新日期：1993-01-01 00:00:00
abstract：:Epigenetic memories are acquired information included in the chromatin or DNA such as methylation and histone modifications. Recent studies suggest that epigenetic memories determine the types of differentiated cells in each tissue. Moreover, the development of metabolic diseases induced by environmental factors durin...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-981-10-5526-3_2
更新日期：2018-01-01 00:00:00
abstract：:The origin of DNA replication of bacteriophage f1 consists of two functional domains: 1) a "core region", about 40 nucleotides long, that is absolutely required for viral (plus) strand replication and contains three distinct but partially overlapping signals, a) the recognition sequence for the viral gene II protein, ...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4684-8730-5_18
更新日期：1984-01-01 00:00:00
abstract：:The clinical aspects of gout were described based on the 4,112 patients observed in the same clinic. In this paper mainly, 2,455 cases seen between 1958 and 1973 were described based on a pretrospective computer assisted analysis. The age distribution of the patient had its peak at 50 years of age and the average age ...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4615-9140-5_8
更新日期：1980-01-01 00:00:00
