Ischemic pretreatment delays ischemic brain vasospasm injury in gerbils.

Abstract:

:Three experiments were conducted for the present study. First, to elucidate the mechanism and functional significance underlying ischemic vasoconstriction, we investigated the relationship between arteriolar constriction and tissue energy metabolism during bilateral common carotid artery occlusion in gerbils. Second, to identify differences in the postischemic recovery of physiologic parameters between short and prolonged brain ischemia, we measured changes in regional cerebral blood flow, microvessel diameter, brain temperature, and electrophysiologic response. Third, to explore the physiological mechanism of ischemic tolerance, we studied vascular response and intracerebral oxygenation states after acute global ischemia with and without pretreatment by mild ischemic stress. Here, we identify one of the physiologic mechanisms of the ischemic tolerance caused by brief ischemic pretreatment.

journal_name

Adv Exp Med Biol

authors

Seiyama A,Yoshikawa N,Imamura Y

doi

10.1007/978-1-4939-0620-8_33

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

247-252

eissn

0065-2598

issn

2214-8019

journal_volume

812

pub_type

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