Comparative study of CD26 as a Th1-like and CD30 as a potential Th2-like operational marker in leprosy.

Abstract:

:In the last years we have been able to establish CD26 as an operational marker for a human Th1-like reaction in various granulomatous diseases. Recently, CD30 was described as a marker for a Th2-type reaction, where CD30 is preferentially expressed and its soluble form released by human T cell clones producing Th2-type cytokines. To evaluate the possibility of CD30 as an eventual operational marker for a human Th2-like reaction in vivo, we performed immunohistological stainings on frozen sections of skin biopsies from patients with lepromatous and tuberculoid leprosy. A maximum of three to four CD30-positive cells was found per section, and there was no difference in the accumulation of CD30-positive cells between the tuberculoid and the lepromatous form of leprosy. With respect to CD26-positive cells, a high number was found in tuberculoid leprosy in contrast to a greatly reduced expression of CD26 in lepromatous leprosy. We conclude that, while CD26 was confirmed as an operational marker for a Th1-like reaction in leprosy, CD30 does not represent an operational Th2 marker in this disease.

journal_name

Adv Exp Med Biol

authors

Seitzer U,Scheel-Toellner D,Hahn M,Heinemann G,Mattern T,Flad HD,Gerdes J

doi

10.1007/978-1-4757-9613-1_28

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

217-21

eissn

0065-2598

issn

2214-8019

journal_volume

421

pub_type

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