Abstract：
:Oxidative stress mediates the cell damage in several neurodegenerative diseases, some of which are Alzheimer's disease (AD), multiple sclerosis and Parkinson's disease (PD). In this study, we investigated whether the taurine-rich cuttlefish extract could exert a protective effect on damaged human neuroblastoma SH-SY5Y cells induced by hydrogen peroxide (H2O2). Our results revealed that pre-treatment with cuttlefish extract effectively increased the cell viability by protecting the cells from intracellular reactive oxygen species (ROS) induced by H2O2 exposure. Furthermore, apoptosis related proteins Bcl-2 and Bax were investigated by western-blot analysis and results indicated that cuttlefish extract promoted the expression of anti-apoptotic Bcl-2 protein while inhibiting the expression of pro-apoptotic Bax protein. Therefore, cuttlefish extract containing the ability of scavenging excessive ROS, the capacity of anti-oxidative stress, could be employed in neurodegenerative disease prevention. In conclusion, the results suggest that cuttlefish extract could be used as a potential candidate for preventing several human neurodegenerative and other disorders caused by oxidative stress.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Kim YS,Kim EK,Hwang JW,Kim JS,Shin WB,Dong X,Nawarathna WPAS,Moon SH,Jeon BT,Park PJdoi
10.1007/978-94-024-1079-2_22subject
Has Abstractpub_date
2017-01-01 00:00:00pages
243-254eissn
0065-2598issn
2214-8019journal_volume
975 Pt 1pub_type
杂志文章abstract：:The effects of imprinted genes on fetal growth and development have been firmly established. By and large, their roles conform to a conflict over provision of limited maternal resources to offspring, such that paternally expressed imprinted genes in offspring generally promote growth of the fetus, while maternally exp...
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abstract：:Islet transplantation is emerging as a viable treatment option for selected patients with type 1 diabetes. Following the initial report in 2000 from Edmonton of insulin independence in seven out of seven consecutive recipients, there has been a huge expansion in clinical islet transplantation. The challenge we now fac...
journal_title：Advances in experimental medicine and biology
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doi：10.1007/978-90-481-3271-3_30
更新日期：2010-01-01 00:00:00
