Abstract：
:Extracellular free sodium (Na+)o and calcium (Ca2+)o concentration changes were measured in the rat motor cortex, using ion-selective microelectrodes. During ionophoretic applications of excitatory amino acids, decreases in (Na2+)o and in (Ca2+)o were observed. Ca2+ signals were not or very little modified by applications of tetrodotoxin while Na+ signals were slightly depressed, up to 20%. Laminar profile analysis revealed that, while the magnitude of Na+ signals was rather constant throughout the cortex, Ca2+ signals were largest in upper cortical layers. Lesioning and pharmacological experiments indicated that the corresponding permeabilities were most probably located on apical dendrites of pyramidal tract neurons. The relative amplitude of Na+ and Ca2+ signals induced by the release of the glutamate agonists N-methyl-D-aspartate, quisqualate and kainate and the shape of the laminar profile of such responses indicated that different ionic permeabilities located on different neurons underlie such responses. Similar experiments performed on chronic epileptogenic motor foci in rats indicated that the amino acid-induced ionic responses were altered. The significance of such alterations for epileptogenesis is discussed.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Pumain R,Louvel J,Kurcewicz Idoi
10.1007/978-1-4684-7971-3_33subject
Has Abstractpub_date
1986-01-01 00:00:00pages
439-47eissn
0065-2598issn
2214-8019journal_volume
203pub_type
杂志文章abstract：:G-protein coupled receptors (GPCRs) are seven helical transmembrane proteins that mediate cell-to-cell communication. They also form the largest superfamily of drug targets. Hence detailed studies of the three dimensional structure and dynamics are critical to understanding the functional role of GPCRs in signal trans...
journal_title：Advances in experimental medicine and biology
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doi：10.1007/978-3-319-40764-7_9
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doi：10.1007/978-3-319-02970-2_6
更新日期：2014-01-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1007/978-1-4614-4711-5_14
更新日期：2012-01-01 00:00:00
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更新日期：2013-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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更新日期：2014-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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更新日期：2013-01-01 00:00:00
abstract：:Challenging environment of space causes several pivotal alterations in living systems, especially due to microgravity. The possibility of simulating microgravity by ground-based systems provides research opportunities that may lead to the understanding of in vitro biological effects of microgravity by eliminating the ...
journal_title：Advances in experimental medicine and biology
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更新日期：2020-01-01 00:00:00
