Immune Checkpoint Inhibitors-Induced Colitis.

Abstract:

:Immune checkpoint inhibitors (ICIs) have shown significant benefit in cancer patients, but are associated with immune-related adverse events (irAEs), that can affect the gastrointestinal tract resulting in diarrhea and colitis. IrAEs range from mild self-limiting to severe life-threatening disease, which potentially limit the use of these medications. Diagnosis of ICI-induced colitis is based on clinical symptoms, physical examination, stool tests, endoscopic evaluation, and/or imaging. Current management strategy is mainly anti-diarrheal agents for mild symptoms, and immunosuppressants (e.g., corticosteroids, and infliximab or vedolizumab) for more severe cases.

journal_name

Adv Exp Med Biol

authors

Tian Y,Abu-Sbeih H,Wang Y

doi

10.1007/978-3-030-02505-2_7

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

151-157

eissn

0065-2598

issn

2214-8019

journal_volume

995

pub_type

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