Abstract：
:The respiratory network is sensitive to both chemical and mechanosensory feedback and exhibits considerable plasticity when exposed to repeated respiratory perturbations. One example of respiratory plasticity is long-term facilitation (LTF) - a long-term enhancement in respiratory activity induced by intermittent hypoxia. Although intermittent hypoxia ranging from 5-min to 10-s has been shown to trigger respiratory LTF, it is unknown whether brief repeated airway obstruction as experience in obstructive sleep apnea could trigger LTF of respiratory motor outflow. Here we show that brief (15-s), repeated apneas trigger LTF of genioglossus muscle tone in rats. We also show that vagal feedback is important for the expression of apnea-induced LTF because it was not inducible when vagal feedback was impaired. Our results demonstrate a novel mechanism for triggering respiratory neuroplasticity and may have implications for maintenance of airway patency during sleep.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Tadjalli A,Duffin J,Peever Jdoi
10.1007/978-1-4419-5692-7_61subject
Has Abstractpub_date
2010-01-01 00:00:00pages
297-301eissn
0065-2598issn
2214-8019journal_volume
669pub_type
杂志文章abstract：:Achromatopsia (ACHM) is caused by a progressive loss of cone photoreceptors leading to color blindness and poor visual acuity. Animal studies and human clinical trials have shown that gene replacement therapy with adeno-associate virus (AAV) is a viable treatment option for this disease. Although there have been succe...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4614-3209-8_87
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journal_title：Advances in experimental medicine and biology
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
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journal_title：Advances in experimental medicine and biology
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doi：
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abstract：:1) The immunological mechanism of protection against dental caries has been investigated by passive immunization with antisera to S. mutans in the rhesus monkey. 2) Passive immunization with separated IgG, IgM and IgA from sera of immunized monkeys supports the concept that IgG, unlike IgA or IgM antibodies are protec...
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pub_type： 杂志文章
doi：10.1007/978-1-4684-3369-2_35
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journal_title：Advances in experimental medicine and biology
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doi：
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journal_title：Advances in experimental medicine and biology
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-030-21162-2_5
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4419-0901-5_3
更新日期：2009-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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doi：10.1007/978-3-319-76735-2_14
更新日期：2018-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4615-9355-3_42
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journal_title：Advances in experimental medicine and biology
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doi：10.1007/978-1-4615-3448-8_5
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journal_title：Advances in experimental medicine and biology
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doi：10.1007/978-3-030-19385-0_7
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journal_title：Advances in experimental medicine and biology
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4615-5855-2_35
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abstract：:Although mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and disrupted lipid and calcium (Ca2+) homeostasis are classically associated with both insulin resistance and β-cell dysfunction in type 2 diabetes mellitus (T2DM), the interplay between these metabolic stresses is less known. Both organelles inte...
journal_title：Advances in experimental medicine and biology
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journal_title：Advances in experimental medicine and biology
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
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abstract：:Considering the devastating effects of neurodegenerative disorders and the increasing number of people affected by them, an early diagnosis even presymptomatic, prior to serious mental deterioration is necessary. Therefore, screening for biomarkers, especially glycolipids, in the biological matrices, either tissues or...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-030-15950-4_42
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