Small Angle Scattering: Historical Perspective and Future Outlook.

Abstract:

:Small angle scattering (SAS) is a powerful and versatile tool to elucidate the structure of matter at the nanometer scale. Recently, the technique has seen a tremendous growth of applications in the field of structural molecular biology. Its origins however date back to almost a century ago and even though the methods potential for studying biological macromolecules was realized already early on, it was only during the last two decades that SAS gradually became a major experimental technique for the structural biologist. This rise in popularity and application was driven by the concurrence of different key factors such as the increased accessibility to high quality SAS instruments enabled by the growing number of synchrotron facilities and neutron sources established around the world, the emerging need of the structural biology community to study large multi-domain complexes and flexible systems that are hard to crystalize, and in particular the development and availability of data analysis software together with the overall access to computational resources powerful enough to run them. Today, SAS is an established and widely used tool for structural studies on bio-macromolecules. Given the potential offered by the next generation X-ray and neutron sources as well as the development of new, innovative approaches to collect and analyze solution scattering data, the application of SAS in the field of structural molecular biology will certainly continue to thrive in the years to come.

journal_name

Adv Exp Med Biol

authors

Weiss TM

doi

10.1007/978-981-10-6038-0_1

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

1-10

eissn

0065-2598

issn

2214-8019

journal_volume

1009

pub_type

历史文章,杂志文章,评审
  • Tongue Image Analysis and Its Mobile App Development for Health Diagnosis.

    abstract::Computer-aided diagnosis provides a medical procedure that assists physicians in interpretation of medical images. This work focuses on computer-aided tongue image analysis specifically, based on Traditional Chinese Medicine (TCM). Tongue diagnosis is an important component of TCM. Computerized tongue diagnosis can ai...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-981-10-5717-5_5

    authors: Kanawong R,Obafemi-Ajayi T,Liu D,Zhang M,Xu D,Duan Y

    更新日期:2017-01-01 00:00:00

  • Role of Inflammation in Psychiatric Disorders.

    abstract::Psychiatric disorders are too multifactorial to be defined as a primarily inflammatory disorder, and increased inflammatory response is not specific to mental disorder only. Numerous factors are involved in neuroinflammation, and there also are many confounding variables, making it difficult to obtain consistent outco...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-981-32-9721-0_24

    authors: Jeon SW,Yoon HK,Kim YK

    更新日期:2019-01-01 00:00:00

  • XPC: its product and biological roles.

    abstract::The XPC protein is a component of a heterotrimeric complex that is essential for damage recognition in a nucleotide excision repair subpathway that operates throughout the genome. Biochemical analyses have revealed that the broad substrate specificity of this repair system is based on the structure-specific DNA bindin...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-0-387-09599-8_6

    authors: Sugasawa K

    更新日期:2008-01-01 00:00:00

  • Crosslinking of nucleic acids and proteins by bisulfite.

    abstract::Sodium bisulfite is a food and beverage additive. It is also a salt of the urban air pollutant, sulfur dioxide. Bisulfite catalyzes, at neutral pH and physiological temperatures, the transamination reactions of cytosine derivatives with amines. The products of the reactions are N4-substituted cytosines. Both the alpha...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4684-3282-4_37

    authors: Shapiro R,Gazit A

    更新日期:1977-01-01 00:00:00

  • E-Health Application for E-Blood Analysis, E-Diagnosis, and Digital Diet Guidance.

    abstract::This paper describes a comprehensive application with three features to diagnose common and rare diseases and to optimize health and vitality of the user with the help of broad databases and state-of-the-art technologies. The features comprise: 1. A digital blood analysis for optimizing the patient's metabolism and he...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-3-030-32622-7_32

    authors: Singh P

    更新日期:2020-01-01 00:00:00

  • Prevention of diabetes-related retinal microangiopathy with aldose reductase inhibitors.

    abstract::Before any clinical signs of diabetic retinopathy can be detected, two major histopathological lesions occur in the walls of retinal capillaries: basement membrane thickening; and loss of intramural pericytes (mural cells). A decrease in the number of pericyte to endothelial cell junctions also occurs under diabetic c...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4684-5616-5_45

    authors: Robison WG Jr

    更新日期:1988-01-01 00:00:00

  • Melanocortins in brain inflammation: the role of melanocortin receptor subtypes.

    abstract::The melanocortins (MC) are released from neurons and paracrine cells in the CNS where they are involved in important physiological functions, including regulation of body temperature and immune responses. MC bind to melanocortin receptors, a class of cell surface G-protein-coupled receptors. Of the five subtypes of MC...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4419-6354-3_5

    authors: Muceniece R,Dambrova M

    更新日期:2010-01-01 00:00:00

  • Molecular mechanism of osteochondroprogenitor fate determination during bone formation.

    abstract::Osteoblasts and chondrocytes, which derive from a common mesenchymal precursor (osteochondroprogenitor), are involved in bone formation and remodeling in vivo. Determination of osteochondroprogenitor fate is under the control of complex hormonal and local factors converging onto a series of temporospatial dependent tr...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-0-387-34133-0_28

    authors: Zou L,Zou X,Li H,Mygind T,Zeng Y,Lü N,Bünger C

    更新日期:2006-01-01 00:00:00

  • Isolation and properties of two rat plasma T-kininogens.

    abstract::Two species of T-kininogen which release T-kinin (Ile-Ser-bradykinin) have been purified from plasma of rats treated with Freund's complete adjuvant. The molecular weight was estimated to be 69,000 for either T-kininogen I and II by SDS-polyacrylamide gel electrophoresis. Trypsin released one mole of T-kinin from one ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4684-5143-6_10

    authors: Okamoto H,Greenbaum LM

    更新日期:1986-01-01 00:00:00

  • Activity of Lysosomal Enzymes During Protein Malnutrition and Progesterone Supplementation in the Mouse.

    abstract::This study investigated the effects of protein malnutrition and progesterone supplementation on the activities of a spectrum of lysosomal enzymes in tissue fragments of mouse liver and kidney. The working hypothesis was that the known anti-stress action of progesterone could have to do with the inhibition of lysosomes...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/5584_2019_425

    authors: Stanisławska I,Witek B,Czarny-Działak M,Pałka-Łebek E,Łyp M

    更新日期:2019-01-01 00:00:00

  • Metabolic correlates of fatigue from different types of exercise in man.

    abstract::It is well established that muscle fatigue, defined as a decline in maximal force generating capacity, is a common response to muscular activity. To what extent metabolic factors contribute to the reduced muscle function is still debated. Metabolic effects can affect muscle through different processes, either through ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4899-1016-5_15

    authors: Vøllestad NK

    更新日期:1995-01-01 00:00:00

  • Age-Related Changes in Physiological Reactivity to a Stress Task: A Near-Infrared Spectroscopy Study.

    abstract::Aging is associated with changes in biological functions, such as reduced cardiovascular responses to stressful tasks. However, less is known about the influence of age on the reactivity of the prefrontal cortex (PFC) to acute stressors. Therefore, this study aimed to investigate the effects of a computerized-controll...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-3-319-55231-6_21

    authors: Brugnera A,Zarbo C,Adorni R,Gatti A,Compare A,Sakatani K

    更新日期:2017-01-01 00:00:00

  • Menin: the protein behind the MEN1 syndrome.

    abstract::The cloning of the MEN1 gene in 1997 led to the characterization of menin, the protein behind the multiple endocrine neoplasia Type 1 syndrome. Menin, a novel nuclear protein with no homology to other gene products, is expressed ubiquitously. MEN1 missense mutations are dispersed along the coding region of the gene bu...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4419-1664-8_3

    authors: Papaconstantinou M,Maslikowski BM,Pepper AN,Bédard PA

    更新日期:2009-01-01 00:00:00

  • Impairment of Immune Function in Children with Familial Hemophagocytic Lymphohistiocytosis.

    abstract::Hemophagocytic lymphohistiocytosis (HLH) is a severe systemic syndrome associated with hyperactivation of macrophages and impaired regulation of the immune system. Two forms of HLH are currently recognized: genetically determined or familial (FHLH), and secondarily developed in the course of primary diseases, like aut...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/5584_2016_210

    authors: Popko K,Jasińska J,Górska E,Demkow U,Balwierz W,Maciejka-Kembłowska L,Badowska W,Wachowiak J,Drabko K,Malinowska I

    更新日期:2016-01-01 00:00:00

  • Recent Advances in the Genetics of Hypertension.

    abstract::Hypertension is a silent killer worldwide, caused by both genetic and environmental factors. Until now, genetic and genomic association studies of hypertension are reporting different degree of association on hypertension. Hence, it is essential to gather all the available information on the reported genetic loci and ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/5584_2016_75

    authors: Wei LK,Au A,Teh LK,Lye HS

    更新日期:2017-01-01 00:00:00

  • Symptoms: Chemotherapy-Induced Peripheral Neuropathy.

    abstract::Chemotherapy-induced peripheral neuropathy (CIPN) is a problematic, treatment-induced toxicity that has the potential to impact quality of life and limit the doses of curative intent therapy. This therapy-induced side effect is one of the most troublesome in oncology clinical practices, considering the morbidity, the ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-319-16366-6_6

    authors: Schneider BP,Hershman DL,Loprinzi C

    更新日期:2015-01-01 00:00:00

  • A Successful Combination: Coupling SE-HPLC with SAXS.

    abstract::A monodispersed and ideal solution is a central (unique?) requirement of SAXS to allow one to extract structural information from the recorded pattern. On-line Size Exclusion Chromatography (SEC) marked a major breakthrough, separating particles present in solution according to their size. Identical frames under an el...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-981-10-6038-0_11

    authors: Pérez J,Vachette P

    更新日期:2017-01-01 00:00:00

  • HLA-B27-bound peptide repertoires: their nature, origin and pathogenetic relevance.

    abstract::Peptide binding is a central biological property of HLA-B27. The availability of HLA-B27 subtypes differentially associated to ankylosing spondylitis provides a unique tool to explore the relationship between peptide specificity and pathogenetic potential. Many studies have focused on defining the nature of subtype-bo...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4419-0298-6_14

    authors: de Castro JA

    更新日期:2009-01-01 00:00:00

  • Models of Short-Term Synaptic Plasticity.

    abstract::We focus on dynamical descriptions of short-term synaptic plasticity. Instead of focusing on the molecular machinery that has been reviewed recently by several authors, we concentrate on the dynamics and functional significance of synaptic plasticity, and review some mathematical models that reproduce different proper...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-319-62817-2_3

    authors: Barroso-Flores J,Herrera-Valdez MA,Galarraga E,Bargas J

    更新日期:2017-01-01 00:00:00

  • Chemosensitive afferent nerves in the regulation of gastric blood flow and protection.

    abstract::The experimental use of capsaicin has made possible the discovery that chemosensitive neurons participate in the activation of endogenous mechanisms of protection in the face of pending injury to the gastric mucosa. At present, the pathophysiological potential of this neural emergency system is best reflected by the g...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:

    authors: Holzer P

    更新日期:1995-01-01 00:00:00

  • Cysteine peptidases of kinetoplastid parasites.

    abstract::We review Clan CA Family C1 peptidases of kinetoplastid parasites (Trypanosoma and Leishmania) with respect to biochemical and genetic diversity, genomic organization and stage-specificity and control of expression. We discuss their contributions to parasite metabolism, virulence and pathogenesis and modulation of the...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4419-8414-2_6

    authors: Caffrey CR,Lima AP,Steverding D

    更新日期:2011-01-01 00:00:00

  • Glucocorticoids and the Cardiovascular System.

    abstract::Glucocorticoids affect the developing and mature cardiovascular system in profound and, at times, contradictory ways. The glucocorticoid receptor is ubiquitous in most cell types and conserved across species, highlighting its importance in development and homeostasis. Despite the fact that the glucocorticoid receptor ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4939-2895-8_13

    authors: Goodwin JE

    更新日期:2015-01-01 00:00:00

  • Demonstration of in vivo effects of ACE inhibitors by the use of autoregressive modelling.

    abstract::We investigated, with use of a technique of feedback analysis, the dynamic changes in and around the renin-angiotensin system in vivo induced by ACE inhibition. Prolonged studies were performed over a half year on rabbits, which were treated by daily injections of saline or one of the inhibitors as follows: captopril,...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4615-9543-4_27

    authors: Wada T,Aoyagi T

    更新日期:1989-01-01 00:00:00

  • Cardiovascular Risk Factors in Obese Children and Adolescents.

    abstract::The aim of the study was to analyze cardiometabolic risk factors andcarotid intima-media thickness (IMT) in obese children. We studied 122 obese children fulfilling the criteria of the International Obesity Task Force and 58 non-obese children. Anthropometric parameters, blood pressure, lipid profile, C-reactive prote...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/5584_2015_168

    authors: Rumińska M,Majcher A,Pyrzak B,Czerwonogrodzka-Senczyna A,Brzewski M,Demkow U

    更新日期:2016-01-01 00:00:00

  • In vitro analysis of xenoestrogens by enzyme linked receptor assays (ELRA).

    abstract::Receptor binding assays are a modern approach to the effects-related analysis of xenoendocrines. Human estrogen receptors are used to develop an analytical tool for the detection of estrogenic substances in environmental samples. A sensitive Enzyme Linked Receptor Assay (ELRA) was developed in a microwell plate format...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4899-0089-0_13

    authors: Seifert M,Haindl S,Hock B

    更新日期:1998-01-01 00:00:00

  • Investigating a novel protein using mass spectrometry: the example of tumor differentiation factor (TDF).

    abstract::Better understanding of central nervous system (CNS) molecules can include the identification of new molecules and their receptor systems. Discovery of novel proteins and elucidation of receptor targets can be accomplished using mass spectrometry (MS). We describe a case study of such a molecule, which our lab has stu...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-319-06068-2_25

    authors: Woods AG,Sokolowska I,Deinhardt K,Darie CC

    更新日期:2014-01-01 00:00:00

  • The role of inflammatory cells in angiogenesis in multiple myeloma.

    abstract::Both innate and adaptive immune cells are involved in the mechanisms of endothelial cell proliferation, migration and activation, via production and release of a large spectrum of pro-angiogenic mediators, thus creating the specific microenvironment that favors increased rate of tissue vascularization. In this article...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-0348-0837-8_14

    authors: Ribatti D,Vacca A

    更新日期:2014-01-01 00:00:00

  • The Structure of the Periostin Gene, Its Transcriptional Control and Alternative Splicing, and Protein Expression.

    abstract::Although many studies have described the role of periostin in various diseases, the functions of periostin derived from alternative splicing and proteinase cleavage at its C-terminus remain unknown. Further experiments investigating the periostin structures that are relevant to diseases are essential for an in-depth u...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-981-13-6657-4_2

    authors: Kudo A

    更新日期:2019-01-01 00:00:00

  • Acute Myeloid Leukemia Stem Cell Heterogeneity and Its Clinical Relevance.

    abstract::The failure of complete remissions to reliably translate into cures in acute myeloid leukemia (AML) can be explained by the leukemia stem cell (LSC) paradigm, which hypothesizes that rare leukemia cells with stem cell features, including self-renewal capacity and drug resistance, are primarily responsible for both dis...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-030-14366-4_9

    authors: Karantanos T,Jones RJ

    更新日期:2019-01-01 00:00:00

  • Localization of kallikreins in the human parotid gland and in the human kidney: a comparative study of immunohistochemistry and enzyme histochemistry.

    abstract::Kallikreins were localized in the human parotid gland and in the human kidney from two different aspects of the enzyme: the enzyme antigenicity and the enzyme activity. In the human parotid gland, the kallikrein antigenicity and the enzyme activity were identical in their locations in the ductal cells. In the human ki...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4684-5143-6_4

    authors: Kimura K,Moriya H

    更新日期:1986-01-01 00:00:00