Abstract:
:The Notch pathway is crucial in the regulation of stem cells biology. Notch-mediated signalling controls several aspects of tissue homeostasis in both embryonic and adult tissues, balancing stem cells maintenance and differentiation. Although the major elements of the pathway are well conserved throughout evolution, its fine regulation varies among different systems. In this review, we are focusing at the differences and analogies of Notch activity in different animal models, comparing stem cells of various tissues in both adulthood and development. We summarize the major mode of action of the Notch-pathway in dependency to the type of ligand, cross-talk control and transcriptional regulation adopted by stem cells to preserve their undifferentiation status or complete their maturation.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Bigas A,Porcheri Cdoi
10.1007/978-3-319-89512-3_12subject
Has Abstractpub_date
2018-01-01 00:00:00pages
235-263eissn
0065-2598issn
2214-8019journal_volume
1066pub_type
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