Biodegradable Polymeric Nanocarrier-Based Immunotherapy in Hepatitis Vaccination.

Abstract:

:Various commercial vaccines are used for immunization against hepatitis B. However, these immunotherapeutic vaccines require invasive administration, which can induce side effects, and require multiple shots to elicit an immune response, limiting their efficacy. Compared to traditional hepatitis B vaccines, polymer nanoparticles have more advantageous inherent properties as vaccine delivery carriers, providing increased stability of encapsulated antigen, the possibility of single-shot immunotherapy, and the capability of mucosal administration, which allows various routes of vaccination. In this review, we present up-to-date information on the potential of a biodegradable nanoparticle-based delivery system in treating hepatitis B. We also discuss the application of nanoparticles in various vaccines and highlighted strategies for eliciting an appropriate immune response.

journal_name

Adv Exp Med Biol

authors

Hong SJ,Ahn MH,Lee YW,Pal S,Sangshetti J,Arote RB

doi

10.1007/978-981-13-0950-2_16

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

303-320

eissn

0065-2598

issn

2214-8019

journal_volume

1078

pub_type

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