Abstract：
:Nanomaterials are invading our environment due to their increasing use in a very broad range of sectors making human exposure foreseeable during the life cycle of these materials. Inhalation is one of the most frequent routes of exposure in case of unintentional exposure and the small size of nanomaterials allows them to reach the deep lung. Understanding the fate and effects of nanomaterials is a great challenge for scientists as they exhibit a huge physico-chemical diversity that drives their biological reactivity. It is critical to determine the fate of nanomaterials at their route of entry in the organism as this will determine their local and/or systemic effects. In this review we will describe the epithelial barriers and the clearance processes of the respiratory tract. The mechanisms involved in the internalization of nanomaterials by respiratory cells and their ability to cross the epithelial barrier will be presented, highlighting methodologies and the role of the nanomaterial physico-chemical properties.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Puisney C,Baeza-Squiban A,Boland Sdoi
10.1007/978-3-319-72041-8_2subject
Has Abstractpub_date
2018-01-01 00:00:00pages
21-36eissn
0065-2598issn
2214-8019journal_volume
1048pub_type
杂志文章,评审abstract：:CEP290 mutations cause a spectrum of ciliopathies, including Leber congenital amaurosis. Milder retinal diseases have been ascribed to exclusion of CEP290 mutant exons through basal exon skipping (BES) and/or nonsense-associated altered splicing (NAS). Here, we report two siblings with some preserved vision despite bi...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
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abstract：:Rats fed a high-fat diet before and during lactation have difficulty initiating lactation and have high pup mortality rates, low milk production and, consequently, poor pup growth. To determine if these adverse outcomes can be mitigated with dietary changes made after delivery, obese Sprague-Dawley rats (who had previ...
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abstract：:CA19-9 (carbohydrate antigen 19-9, also called cancer antigen 19-9 or sialylated Lewis a antigen) is the most commonly used and best validated serum tumor marker for pancreatic cancer diagnosis in symptomatic patients and for monitoring therapy in patients with pancreatic adenocarcinoma. Normally synthesized by normal...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-94-017-7215-0_15
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abstract：:Renewal of rod photoreceptor outer segments in the mammalian eye involves synchronized diurnal shedding after light onset of spent distal outer segment fragments (POS) linked to swift clearance of shed POS from the subretinal space by the adjacent retinal pigment epithelium (RPE). Engulfed POS phagosomes in RPE cells ...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-3-319-17121-0_95
更新日期：2016-01-01 00:00:00
abstract：:The development and validation of scientific alternatives to animal testing is important not only from an ethical perspective (implementation of 3Rs), but also to improve safety assessment decision making with the use of mechanistic information of higher relevance to humans. To be effective in these efforts, it is how...
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pub_type： 杂志文章,评审
doi：10.1007/978-3-319-33826-2_14
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4615-4863-8_41
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-319-95046-4_27
更新日期：2018-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 临床试验,杂志文章
doi：10.1007/978-1-4419-1241-1_56
更新日期：2010-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4615-2920-0_25
更新日期：1993-01-01 00:00:00
abstract：:In this chapter, the impact of HCN1 channels on the retinal functional properties was presented. HCN1 channel loss led to an intensity-dependent prolongation of the rod system response, in agreement with the threshold mechanism of activation of the channel. Rod outer segment functionality was not altered, supporting t...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4614-0631-0_103
更新日期：2012-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-981-10-5562-1_6
更新日期：2017-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4899-5199-1_15
更新日期：1979-01-01 00:00:00
abstract：:The 1st International Conference on Oral Mucosal Immunity and the Microbiome (OMIM) took place at the Avra Imperial Hotel, Chania, Crete, Greece, between 26th and 30th September 2018, under the auspices of the Aegean Conferences. This was the first Aegean Conference of its kind in thematic oral research, and a unique ...
journal_title：Advances in experimental medicine and biology
pub_type：
doi：10.1007/978-3-030-28524-1_1
更新日期：2019-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4614-1704-0_9
更新日期：2012-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-94-007-7893-1_14
更新日期：2014-01-01 00:00:00
abstract：:Within the cochlea, broadband sounds like speech and music are filtered into a series of narrowband signals, each of which can be considered as a relatively slowly varying envelope (ENV) imposed on a rapidly oscillating carrier (the temporal fine structure, TFS). Information about ENV and TFS is conveyed in the timing...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-3-319-25474-6_1
更新日期：2016-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4614-8289-5_1
更新日期：2013-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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更新日期：2020-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-94-007-0782-5_5
更新日期：2011-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
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更新日期：2010-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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更新日期：2018-01-01 00:00:00
abstract：:We review here the covalent photo-binding induced by visible light between the essential amino acid tryptophan and the vitamin riboflavin. We discuss the biological implications of this photoadduct in relation to the hepatotoxic and cytotoxic effect associated to parenteral nutrients and to culture media exposed to th...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4899-2626-5_3
更新日期：1991-01-01 00:00:00
abstract：:Along with food safety issues due to mycotoxins, the effects of Fusarium infections on malt and beer quality can be disastrous. While some of the Fusarium head blight mycotoxins, such as DON, present in infected barley may be lost during steeping, the Fusarium mold is still capable of growth and mycotoxin production d...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4615-0629-4_22
更新日期：2002-01-01 00:00:00
abstract：:The aim of the study was to analyze cardiometabolic risk factors andcarotid intima-media thickness (IMT) in obese children. We studied 122 obese children fulfilling the criteria of the International Obesity Task Force and 58 non-obese children. Anthropometric parameters, blood pressure, lipid profile, C-reactive prote...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
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更新日期：2016-01-01 00:00:00
abstract：:Soundscape ecological research in terrestrial systems is relatively new. In this paper, I present a brief summary of the origins of this research area, describe research questions related to several research thrusts that are ongoing, summarize several soundscape projects that exist and how these relate to the research...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
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更新日期：2016-01-01 00:00:00
abstract：:In this chapter, we intend to review gene therapy concepts applied to the potential treatment of tyrosinemia for parents and pediatricians. Therefore, our main objective is to give general informations in a comprehensible manner. Considering the nature of tyrosinemia and the current state of technology, a particular f...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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更新日期：2017-01-01 00:00:00
abstract：:Two different neural implementations of support vector machines are described and applied to one-shot trainable pattern recognition. The first model is based on oscillating associative memory and is mapped to the olfactory system. The second model is founded on competitive queuing memory originally employed for genera...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4614-0164-3_16
更新日期：2011-01-01 00:00:00
abstract：:In the field of rare diseases, registries are considered power tool to develop clinical research, to facilitate the planning of appropriate clinical trials, to improve patient care and healthcare planning. Therefore high quality data of rare diseases registries is considered to be one of the most important element in ...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-319-67144-4_8
更新日期：2017-01-01 00:00:00
