The molecular basis of mechanosensory transduction.

Abstract:

:Multiple senses, including hearing, touch and osmotic regulation, require the ability to convert force into an electrical signal: A process called mechanotransduction. Mechanotransduction occurs through specialized proteins that open an ion channel pore in response to a mechanical stimulus. Many of these proteins remain unidentified in vertebrates, but known mechanotransduction channels in lower organisms provide clues into their identity and mechanism. Bacteria, fruit flies and nematodes have all been used to elucidate the molecules necessary for force transduction. This chapter discusses many different mechanical senses and takes an evolutionary approach to review the proteins responsible for mechanotransduction in various biological kingdoms.

journal_name

Adv Exp Med Biol

authors

Marshall KL,Lumpkin EA

doi

10.1007/978-1-4614-1704-0_9

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

142-55

eissn

0065-2598

issn

2214-8019

journal_volume

739

pub_type

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