Abstract:
:The chromatin of male germ cells is restructured throughout spermatogenesis. Analysis of differential histone protein patterns at specific stages of spermatogenesis may contribute towards an understanding of the changes in chromatin structure and function during this differentiation process. The most striking changes in histone patterns occur at the stage of pachytene spermatocytes when most of the linker H1 histones are replaced by the testis specific subtype H1t. In addition, replacement of core histone subtypes is observed at this stage. These structural changes precede the reorganization of chromatin at haploid stages when histones are replaced first by transition proteins and then by protamines.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Doenecke D,Drabent B,Bode C,Bramlage B,Franke K,Gavénis K,Kosciessa U,Witt Odoi
10.1007/978-1-4615-5913-9_4subject
Has Abstractpub_date
1997-01-01 00:00:00pages
37-48eissn
0065-2598issn
2214-8019journal_volume
424pub_type
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