Orphan opioid receptor oligonucleotides inhibit HIV-1 expression in human brain cells.

Abstract:

:We found that orphan opioid receptor (OR) mRNA was constitutively expressed in human fetal microglia, astrocytes, and cerebral cortical neurons. An OR antisense oligonucleotide markedly inhibited HIV-1 expression in enriched microglial cell and the mixed glial/neuronal cell cultures but not in the chronically infected promonocytic U1 cells. The sense oligonucleotide also inhibited HIV-1 expression in brain cell cultures. These findings indicate that while human brain cells constitutively express mRNA for OR, antisense oligonucleotides to OR non-specifically inhibit acute HIV-1 infection.

journal_name

Adv Exp Med Biol

authors

Chao CC,Gekker G,Sheng WS,Hu S,Loh HH,Peterson PK

doi

10.1007/978-1-4615-5347-2_10

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

83-90

eissn

0065-2598

issn

2214-8019

journal_volume

437

pub_type

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