Abstract：
:Laser diffraction and photomicrography have been used to monitor sarcomere length changes in single muscle fibres of the frog, at long sarcomere lengths, during fixed end tetani. In the central 90% of all fibres, changes in sarcomere length were consistently less than 0.25 micron. Sarcomere length showed an initial rapid change, followed by a progressively slower increase, which persisted throughout a 4s tetanus. Sarcomere length in the terminal 200-400 microns segment at each end of a fibre decreased rapidly by up to 1 micron in the first second of a tetanus. This shortening was accompanied by a marked increase in disorder of the striation pattern. Maximum isometric tensions in fixed end tetani were much greater than those predicted by crossbridge theory over the entire range of sarcomere lengths studied. An analysis of the intersarcomere dynamics suggests that this extra tension may be explained by known phenomena on the basis of a progressive increase in sarcomere length dispersion along the fibre.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Altringham JD,Pollack GHdoi
10.1007/978-1-4684-4703-3_42subject
Has Abstractpub_date
1984-01-01 00:00:00pages
473-93eissn
0065-2598issn
2214-8019journal_volume
170pub_type
杂志文章abstract：:Mankind has always been interested in investigating and searching for solutions regarding the body deterioration due to factors such as disease, damage caused by trauma, toxins or radiation or just the process of ageing. Here, we summarize the history of scientific advances in solid organ transplantation, in the areas...
journal_title：Advances in experimental medicine and biology
pub_type： 历史文章,杂志文章
doi：10.1007/978-1-4614-2098-9_2
更新日期：2012-01-01 00:00:00
abstract：:Reduced Expression in Immortalized Cell (REIC) was cloned by subtractive hybridization method as a gene whose expression is reduced in many human immortalized and neoplastic tumor cells. The REIC, when over-expressed by an adenovirus (Ad-REIC), exhibited a dramatic therapeutic effect on a wide variety of human cancers...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4614-0254-1_17
更新日期：2011-01-01 00:00:00
abstract：:After some notions on the mechanisms of action of radio-waves on solid tumours, the treatise illustrates the results achieved in the first 125 cases of malignant tumours treated with this method, its results are definitely encouraging, even in cases apparently with no hope. It also describes briefly the histologic mod...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4684-5766-7_41
更新日期：1990-01-01 00:00:00
abstract：:MicroRNAs (miRNAs) are a class of ∼22nt non-coding RNAs that regulate the translational potential and stability of mRNAs. Though constituting only 1-4% of human genes, miRNAs are predicted to regulate more than 60% of all mRNAs. The action of miRNAs is mediated through their associations with Argonaute proteins and mR...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4614-5107-5_10
更新日期：2013-01-01 00:00:00
abstract：:Perforin, a pore-forming protein toxin synthesized and stored in the cytoplasmic vesicles of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells, is secreted when these effector lymphocytes encounter virus-infected or neoplastic cells. Perforin is encoded by a single-copy gene and is critical for immune homeo...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-0-387-72005-0_24
更新日期：2007-01-01 00:00:00
abstract：:The aim of the study was to analyze cardiometabolic risk factors andcarotid intima-media thickness (IMT) in obese children. We studied 122 obese children fulfilling the criteria of the International Obesity Task Force and 58 non-obese children. Anthropometric parameters, blood pressure, lipid profile, C-reactive prote...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/5584_2015_168
更新日期：2016-01-01 00:00:00
abstract：:In the past 12 years, since the first description of C. elegans germ cell apoptosis, this area of research rapidly expanded. It became evident that multiple genetic pathways lead to the apoptotic demise of germ cells. We are only beginning to understand how these pathways that all require the CED-9/Bcl-2, Apaf-1/CED-4...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4614-4015-4_9
更新日期：2013-01-01 00:00:00
abstract：:In the visible/NIR (600-900 nm) three different redox centres are potentially detectable in vivo in mitochondrial cytochrome c oxidase: haem a (605nm), the binuclear haem a3/CuB centre (655 nm) and CuA (830 nm). In this paper we report changes in the steady state reduction of these centres following increases in the r...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-0-387-85998-9_19
更新日期：2009-01-01 00:00:00
abstract：:The experimental use of capsaicin has made possible the discovery that chemosensitive neurons participate in the activation of endogenous mechanisms of protection in the face of pending injury to the gastric mucosa. At present, the pathophysiological potential of this neural emergency system is best reflected by the g...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：
更新日期：1995-01-01 00:00:00
abstract：:Baroreflex is involved in the regulation of arterial blood pressure (BP). An increase in BP activates vagal inhibitory pathways to decrease heart rate; a concomitant decrease in sympathetic discharge reduces vascular resistance. Both responses reduce BP towards normal value. Conversely, a decrease in BP produces oppos...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-94-007-4584-1_25
更新日期：2012-01-01 00:00:00
abstract：:A basket shaped catheter carrying 64 electrodes was developed in the left ventricle (LV) of 53 pigs which had undergone induction of myocardial infarction. Pacing during sinus rhythm, or echocardiographic and hemodynamic measurements as well as pathological studies revealed no significant damage due to the basket cath...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4615-5959-7_27
更新日期：1997-01-01 00:00:00
abstract：OBJECTIVE:To assess the role of cholinergic angonists and antagonists on the growth control of cultured rabbit detrusor smooth muscle cells. DESIGN:Dosage dependent growth curve analysis of smooth muscle cells in standard media to bethanechol and atropine at concentrations from 1 x 10(-5) to 1 x 10(-9) mMol. RESULTS:...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4899-1585-6_33
更新日期：1995-01-01 00:00:00
abstract：:Exercise training (ExT) is widely used for the prevention and treatment of several chronic cardiovascular diseases. However, only recently it started to be recognized as safe and beneficial in pulmonary arterial hypertension. Despite the consistency of its favorable effects on exercise tolerance and quality of life, t...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-981-10-4307-9_17
更新日期：2017-01-01 00:00:00
abstract：:The tremendous progress in engineering and computing power coupled with ultrasound transducer technology and imaging modalities over the past 20 years have encouraged a revival of clinical interest in ultrasound therapy, mainly in High-Intensity Focused Ultrasound (HIFU). So far, the most extensive results from HIFU o...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-319-22536-4_2
更新日期：2016-01-01 00:00:00
abstract：:Gastric polyps occur in 1-4 % of patients undergoing gastroscopy. Although most are sporadic, some gastric polyps are part of an underlying hereditary syndrome. Gastric polyps can be seen in each of the well-known gastrointestinal polyposis syndromes, but also in Lynch syndrome and in several rare not primarily gastro...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-319-41388-4_17
更新日期：2016-01-01 00:00:00
abstract：:Endocrine fibroblast growth factors (FGFs) have been recognized as hormones that regulate a variety of metabolic processes. FGF19 is secreted from intestine upon feeding and acts on liver to suppress bile acid synthesis. FGF21 is secreted from liver upon fasting and acts on adipose tissue to promote lipolysis and resp...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4614-0887-1_2
更新日期：2012-01-01 00:00:00
abstract：:The activation of 17beta-estradiol (E2) to 2-hydroxyestradiol (2-HO-E2), the more genotoxic 4-hydroxyestradiol (4-HO-E2), and the oxidation to the respective quinones constitutes a risk factor in hormonal carcinogenesis. 2-HO-E2 is formed by cytochrome P450 CYP1A1, and 4-HO-E2 is formed by CYP1B1. Both are detoxified ...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-0-387-69080-3_65
更新日期：2008-01-01 00:00:00
abstract：:The processes of bone growth and turnover are tightly regulated by the actions of various signaling molecules, including hormones, growth factors, and cytokines. Imbalances in these processes can lead to skeletal disorders such as osteoporosis or high bone mass disease. It is becoming increasingly clear that serotonin...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-3-319-66653-2_3
更新日期：2017-01-01 00:00:00
abstract：:The rate of the process of ageing studied in this work as well as of other ageing processes observed by us constantly decreases with increasing age. By an adaptation of exponential functions to series of measurements it is possible to estimate the theoretically possible end stage of histological ageing processes for e...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4757-0731-1_37
更新日期：1975-01-01 00:00:00
abstract：:Macromolecules have been prepared containing native insulin carried by a modified insulin skeleton made by partially thiolating the insulin hexamer and forming intermolecular cross-links through disulphide bridges. Oxidation of partially thiolated insulin (0.5-0.7 SH group/mole), formed by reacting insulin with AHTL, ...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4684-3282-4_15
更新日期：1977-01-01 00:00:00
abstract：:We provide evidence that the commercially available preparations of glycopeptides for intravenous application are well tolerated by endothelial cells when applied in concentrations less than 5 mg/ml. Since the antibiotics tested are administered at maximal concentrations of 10 mg/ml, the dose range used in our in vitr...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4615-5381-6_160
更新日期：1998-01-01 00:00:00
abstract：:There is a considerable body of evidence indicating that oxidative stress is a causal factor both in lipofuscinogenesis as well as in aging. Studies on the effects of pro-oxidants and antioxidants on lipofuscin accumulation in cultured rat cardiac myocytes and human glial cells indicated that pro-oxidants accelerate w...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4899-5339-1_2
更新日期：1989-01-01 00:00:00
abstract：:Studies in this laboratory on the nuclear binding sites (acceptors) for progesterone receptor in the developed chick oviduct have resulted in the detection of seasonal variations in the levels and functions of the receptor. Cytosol preparations obtained from the chick oviducts during the winter/spring period between J...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4757-6589-2_13
更新日期：1979-01-01 00:00:00
abstract：:The Notch signaling pathway is a critical component of vascular formation and morphogenesis in both development and disease. Compelling evidence indicates that Notch signaling is required for the induction of arterial-cell fate during development and for the selection of endothelial tip and stalk cells during sproutin...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4614-0899-4_16
更新日期：2012-01-01 00:00:00
abstract：:Fifty-eight semicarbazone and pyrazole derivatives of curcumin have been developed as potential mitigation agents to treat acute radiation syndrome (ARS). Pyridyl (D12, D13), furyl (D56), and phenyl (D68) derivatives of curcumin semi-carbazones were found to provide the highest dose modifying factors (DMF) with respec...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4419-7756-4_39
更新日期：2011-01-01 00:00:00
abstract：:The leukokinin-leukokininogen system is a pathological kinin generating system which is catalyzed by acid proteases present in neoplastic cells, white cells and even normal tissues. The components of the human system including leukokinin-H and leukokininogen have now been isolated and characterized. Very specific prot...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:Flow cytometry is used in the analysis of the multi-parameter optical properties of individual particles such as eukaryotic cells, prokaryotic cells, and viruses in the flow system. Virions, or complexes consisting of virus particles attached to the specific antibody in suspension are individually arranged in a linear...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-94-007-6627-3_10
更新日期：2013-01-01 00:00:00
abstract：:The effects of a single nutrient deficiency on immune function is now most extensively characterized using the dietary zinc deficient murine model. Deficiencies in zinc have rapid adverse effects on host defenses of humans and rodents. This impaired defense seems to be, in part, the result of a reduction in number of ...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4613-0553-8_10
更新日期：1990-01-01 00:00:00
abstract：:We have identified a phosphoprotein phosphatase which dephosphorylates efficiently the NC protein of coronavirus JHM. The activity was found in L-2 murine fibroblasts, Wistar Furth rat neonatal brain extracts, Wistar Furth rat oligodendrocyte primary cells and in Roc-1 cells, an oligodendrocytic hybrid cell line. In b...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4684-5823-7_35
更新日期：1990-01-01 00:00:00
abstract：:Effects of taurine supplementation on lipid peroxide formation and the activities of glutathione (GSH) dependent enzymes in diabetic model mice were investigated. Type I diabetes mellitus was induced by injecting alloxan to ICR mice while type II diabetes mellitus was produced by high calorie diet feeding to genetical...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4899-0117-0_13
更新日期：1998-01-01 00:00:00
