Abstract:
:The experimental use of capsaicin has made possible the discovery that chemosensitive neurons participate in the activation of endogenous mechanisms of protection in the face of pending injury to the gastric mucosa. At present, the pathophysiological potential of this neural emergency system is best reflected by the gastric hyperemic response to acid back-diffusion, a response which is signalled to a large degree by peptidergic afferent neurons. There is good evidence that CGRP released from perivascular afferent nerve endings is an important mediator of the acid-induced hyperemia in the rat gastric mucosa. The vasodilator action of CGRP depends on the formation of NO which functions as a second intercellular messenger of the CGRP- induced vasodilatation. The resulting hyperemia acts to limit acid damage to the superficial part of the mucosa. The hyperemic and protective roles of peptidergic sensory neurons have been studied in most detail in the stomach but there is evidence that they play a similar role in the esophagus, duodenum and colon. Further elucidation of this neural emergency system in the digestive system represents an important area for studies into the pathophysiology and management of gastrointestinal mucosal damage.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Holzer Psubject
Has Abstractpub_date
1995-01-01 00:00:00pages
891-5eissn
0065-2598issn
2214-8019journal_volume
371Bpub_type
杂志文章,评审abstract::Plasticity in the nervous system, whether for establishing connections and networks during development, repairing networks after injury, or modifying connections based on experience, relies primarily on highly coordinated patterns of neural activity. Rhythmic, synchronized bursting of neuronal ensembles is a fundament...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-94-017-8914-1_8
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journal_title:Advances in experimental medicine and biology
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doi:10.1007/978-1-4615-5959-7_17
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4899-5181-6_22
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journal_title:Advances in experimental medicine and biology
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journal_title:Advances in experimental medicine and biology
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-1-4614-1680-7_11
更新日期:2012-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-0-387-74911-2_23
更新日期:2008-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-3-319-66653-2_3
更新日期:2017-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
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更新日期:2005-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
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更新日期:2002-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/978-3-319-93791-5_5
更新日期:2018-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4613-0623-8_8
更新日期:1989-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4614-0164-3_16
更新日期:2011-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/1-4020-3535-7_12
更新日期:2005-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-1-4615-0121-3_29
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journal_title:Advances in experimental medicine and biology
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4615-3030-5_27
更新日期:1992-01-01 00:00:00
abstract::This chapter reviews the present state of knowledge on the activity of enzymes that function with the RNA exosome in the nucleus. In this compartment, the exosome interacts physically and functionally with the exoribonuclease Rrp6 and several cofactors, most prominently Rrp47 and the TRAMP complex. These interactions ...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
abstract::Cell and DNA replicative potentials were studied in 10 strains of skin fibroblasts from unrelated patients with the Werner syndrome (WS) and in a progeric CRL 1277 strain. The lifespans of all WS strains and of CRL 1277 cells are greatly abbreviated in vitro, due to large fractions of non-cycling cells and the basic p...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4684-7853-2_23
更新日期:1985-01-01 00:00:00
abstract::Recent near-infrared spectroscopy (NIRS) studies demonstrated that physical exercise enhances working memory (WM) performance and prefrontal cortex (PFC) activity during WM tasks in normal adults. Interestingly, the effects of rehabilitation (i.e. physiotherapy) on post-stroke patients could be enhanced by motor image...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-3-319-55231-6_31
更新日期:2017-01-01 00:00:00
abstract::This study investigated the relationships between blood pressure, cortical oxygen pressure and hydroxyl radicals in the brain of adult cats during hemorrhagic hypotension and retransfusion. Oxygen pressure in the blood of the cortex was measured optically by the oxygen dependent quenching of phosphorescence and hydrox...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4615-4863-8_21
更新日期:1998-01-01 00:00:00
abstract::Cell-cell communication is crucial to maintain homeostasis in multicellular organism. Cells communicate each other by direct contact or by releasing factors that, soluble or packaged in membrane vesicles, can reach different regions of the organism. To date numerous studies highlighted the existence of several types o...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-981-10-4397-0_2
更新日期:2017-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-3-319-72041-8_12
更新日期:2018-01-01 00:00:00
abstract::As an attempt to recruit the third calcium binding site of thermitase into subtilisin BL, a Bacillus lentus alkaline protease (BLAP), the amino acid sequence from position 50 to 60 and position 92 was modified to the equivalent amino acids in thermitase. The resulting protein, designated BLAPm109, exhibited unusual bi...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4613-0319-0_27
更新日期:1996-01-01 00:00:00
abstract::Transurethral resection (TUR) is the primary mode of therapy for both diagnosis and treatment of bladder cancer. Due to the recurrency of tumoral tissues after TUR further treatment is necessary which is usually in the form of intravesical chemotherapy or immunotherapy. But these therapies have some disadvantages such...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00