Abstract：
:Mankind has always been interested in investigating and searching for solutions regarding the body deterioration due to factors such as disease, damage caused by trauma, toxins or radiation or just the process of ageing. Here, we summarize the history of scientific advances in solid organ transplantation, in the areas strictly linked to transplantation. The period between the end of the 19th and beginning of the 20th century has been called by some authors the "Era of allografting". This was a muddled period with many studies and publications on very diverse transplants, from Kocher's (Nobel Prize in 1909) who transplanted thyroid extracts, to Brown-Sequard who tried to rejuvenate people by using grafts of guinea pig testicle extracts. In the midst of the 20th century, Sir Medawar pointed out that the rejection of transplant organs by the recipient body was mediated by an immunological reaction, which should be modified. Since then, there has been an open period of discovery of new immunosuppressive drugs which have revolutionised the outcomes of solid organ transplantations. New challenges have appeared over the last few years, these efforts have focused on the search to extend graft durability and with it recipient patient survival times, as well as improve their quality of life.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Ortega Fdoi
10.1007/978-1-4614-2098-9_2subject
Has Abstractpub_date
2012-01-01 00:00:00pages
13-26eissn
0065-2598issn
2214-8019journal_volume
741pub_type
历史文章,杂志文章abstract：:The secretion of Yops via the Yersinia type III secretion system (T3SS) is controlled, in part, by a cytoplasmic YopN/TyeA complex. This complex is required to prevent Yop secretion in the presence of extracellular calcium and prior to contact between the bacterium and a eukaryotic cell. In this study we utilized site...
journal_title：Advances in experimental medicine and biology
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doi：10.1007/978-0-387-75681-3_40
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journal_title：Advances in experimental medicine and biology
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doi：10.1007/5584_2016_43
更新日期：2017-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Advances in experimental medicine and biology
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doi：10.1007/978-1-4757-1419-7_57
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-319-25304-6_13
更新日期：2016-01-01 00:00:00
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更新日期：2008-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4419-1241-1_46
更新日期：2010-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-030-34521-1_26
更新日期：2020-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2020-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4471-6458-6_2
更新日期：2014-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-319-50174-1_11
更新日期：2017-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/5584_2020_539
更新日期：2020-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4757-0937-7_8
更新日期：1988-01-01 00:00:00
abstract：:The neoglycolipid (NGL) technology involving the preparation of lipid-linked oligosaccharide probes for binding experiments with carbohydrate-recognizing proteins, and their analysis by mass spectrometry, is a unique and powerful means of discovering oligosaccharide ligands for carbohydrate-binding proteins, and assig...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4615-1267-7_5
更新日期：2001-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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更新日期：2018-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
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更新日期：1995-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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doi：10.1007/5584_2017_79
更新日期：2018-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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更新日期：2016-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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更新日期：2010-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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更新日期：1995-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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更新日期：1975-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-319-55947-6_15
更新日期：2017-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4899-5339-1_23
更新日期：1989-01-01 00:00:00
abstract：:Tumor microenvironment (TME) is composed of tumor cells, immune cells, cytokines, extracellular matrix, etc. The immune system and the metabolisms of glucose, lipids, amino acids, and nucleotides are integrated in the tumorigenesis and development. Cancer cells and immune cells show metabolic reprogramming in the TME,...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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更新日期：2017-01-01 00:00:00
abstract：:The configurations of myosin projections in striated muscles from the marine crab, Portunus trituberculatus were described in the relaxed and rigor states at the full overlap length of the thin and thick filaments. The crystallographic period of the thick filament is 101.5 nm (14.5 nm X 7) and the thick filament has f...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4684-4703-3_21
更新日期：1984-01-01 00:00:00
abstract：:Solid phase fixed peptides are useful tools for the investigation of enzyme substrate interactions. We could show that interactions of target sequences, like e.g. the acceptor domain of G-proteins for the of mono ADP-ribosylation by pertussis toxin and the toxin itself can be studied by this method. Reaction specifici...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4419-8632-0_10
更新日期：1997-01-01 00:00:00
