Abstract:
:DNA topological transitions occur when replication forks encounter other DNA transactions such as transcription. Failure in resolving such conflicts leads to generation of aberrant replication and transcription intermediates that might have adverse effects on genome stability. Cells have evolved numerous surveillance mechanisms to avoid, tolerate, and resolve such replication-transcription conflicts. Defects or non-coordination in such cellular mechanisms might have catastrophic effect on cell viability. In this chapter, we review consequences of replication encounters with transcription and its associated events, topological challenges, and how these inevitable conflicts alter the genome structure and functions.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Achar YJ,Foiani Mdoi
10.1007/978-981-10-6955-0_20subject
Has Abstractpub_date
2017-01-01 00:00:00pages
455-487eissn
0065-2598issn
2214-8019journal_volume
1042pub_type
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