Abstract：
INTRODUCTION:Both the normal and pathological development and involution of the CNS are regulated by an important set of both, 'growth factors' (inducing growth, differentiation, survival, adaptation or plasticity in neurons) and 'ageing factors' (inducing involution, atrophy, necrosis or apoptosis). In neurodegenerative diseases, significant deficits of growth factors and important presence of ageing factors are being detected, mainly in Alzheimer's disease (AD). DEVELOPMENT:In this review, the most important growth factors (NGF, BDNF, neuromodulators, glial factors, etc.) and ageing factors (amyloid, tanatins, calcium, mitochondrial factors, etc.) in the pathogenesis of the AD are discussed. CONCLUSIONS:The knowledge and assessment of these endogenous factors must have an important role in the diagnosis and treatment of the cognitive impairment that characterizes senility and AD.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Toledano Asubject
Has Abstractpub_date
1997-10-01 00:00:00pages
1592-602issue
146eissn
0210-0010issn
1576-6578journal_volume
25pub_type
杂志文章,评审abstract：:The appearance of involuntary movements in the clinical course of reflex sympathetic dystrophy (DSR) constitutes a rare clinical entity. In this context, the most frequent changes in movements are muscle spasms and focal dystonia, although postural tremor, muscle weakness and rhythmic myoclonus have also been describe...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：INTRODUCTION:'Sword stroke' linear scleroderma, which is better known as linear scleroderma en coup de sabre (LSCS), is a rare disease with an uncertain causation that is characterised by progressive craniofacial focal atrophy and is, at least in part, different from Parry-Romberg syndrome (PRS). CASE REPORTS:Here, we...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2005-11-01 00:00:00
abstract：INTRODUCTION:Epileptic seizures and epilepsy are part of daily clinical practice in neurology. Yet, the number of false positive diagnoses is surprisingly high. Almost one out of every five patients treated for epilepsy does not really have this diagnosis, which is a high percentage bearing in mind the social and medic...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：10.33588/rn.6806.2018242
更新日期：2019-03-16 00:00:00
abstract：:The neuropathology of haemorrhagic and hypoxic-ischaemic perinatal encephalopathies and their effect on the post-natal development of the brain, has been studied in children who survived with these lesions (for days, weeks, months and even years). Eventually some children developed neurological sequelae, including epi...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1997-05-01 00:00:00
abstract：INTRODUCTION:There is currently a growing interest for conducting studies into the electrical and neurochemical activity of the pedunculopontine nucleus (PPN) due to the privileged position occupied by this structure in the flow of information to and from the cortex. This nucleus acts as a relay, not only for the motor...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2003-06-16 00:00:00
abstract：INTRODUCTION:The presence of muscarinic receptors on lymphocytes and possible modifications in their number and affinity may be related to cholinergic changes found in muscarinic receptors at a central level. OBJECTIVE:The objective of this paper is to bring the technique for the determination of lymphocyte muscarinic...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1997-06-01 00:00:00
abstract：INTRODUCTION:In Parkinson's disease there are patients with isolated and multiple cognitive impairment, and their cognitive performance ranges from normal to an advanced degree of dementia. Most patients present an executive deficit, either in isolation or combined with other cognitive disorders, which is considered to...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2010-02-08 00:00:00
abstract：INTRODUCTION AND AIMS:Chronic immune-mediated neuropathies are characterised by their being predominantly demyelinating, by being associated to specific antibodies and by their response to immunotherapy. We evaluated the clinical, electrophysiological and immunological responses following treatment with intravenous imm...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2005-03-16 00:00:00
abstract：INTRODUCTION:Many studies have shown that smoking is lower in patients with Parkinson s disease. However, in other investigations this was not observed. The various studies involved showed wide variation with regard to methodology, criteria for diagnosis and periods of observation and hence it is difficult to compare t...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2002-04-01 00:00:00
abstract：INTRODUCTION:The cognitive effects of long-term exposure to organic solvents could be similar to those triggered by certain neurodegenerative diseases. AIMS:The purpose of this study was to evaluate the effects exerted by accumulated exposure on the cognitive functions. PATIENTS AND METHODS:105 subjects with an avera...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-12-01 00:00:00
abstract：INTRODUCTION:Benign idiopathic external hydrocephalus (BIEH) is an age-dependent disorder that is self-limiting in time and has an uncertain aetiology. PATIENTS AND METHODS:A retrospective study was conducted involving 39 patients (16 girls and 23 boys) with BIEH. The following data were analysed for each patient: age...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2005-05-01 00:00:00
abstract：:The Landau-Kleffner syndrome consists of the association of paroxysmal EEG abnormalities, more marked during sleep, acquired aphasia usually of receptive type, and epileptic seizures in three quarters of cases. Additional features include behavioral disturbances that may even present with autistic features, cognitive ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1999-08-16 00:00:00
abstract：INTRODUCTION:The development of scientific advances, constantly opening new frontiers of knowledge, leads to increasing complexity and specialization. DEVELOPMENT:The conflict between the never ending medical specialization and the opposite tendency, which is based mostly on economic grounds, prevents the acquisition ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-08-01 00:00:00
abstract：INTRODUCTION:Cystinosis is a hereditary disease with clinical symptoms that are caused by the accumulation of cystine crystals in different tissues. Distal vacuolar myopathy has been reported as one of its later complications. CASE REPORT:Here, we present the case of a 20-year-old male diagnosed with cystinosis at the...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2005-02-01 00:00:00
abstract：INTRODUCTION:Perforating artery disease is still the main cause of lacunar infarcts (LI), while the relationship between this type of ischemia and carotid stenosis (CS) is controversial. OBJECTIVE:To assess the association between CS and LI in patients with criteria of localized ischemia in the carotid territory separ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-07-16 00:00:00
abstract：INTRODUCTION:Attention deficit disorder with or without hyperactivity (ADHD) is characterised by the patients' inability to pay attention in non selective activities, hyperactivity that is difficult to inhibit, impulsiveness with failure to control their reactions and an unstable personality, which gives rise to diffic...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-03-16 00:00:00
abstract：INTRODUCTION:Visual phenomena can be symptoms of epileptic seizures, although with an uncertain clinical meaning and relationship with the epileptogenic focus. AIMS:To describe the clinical implications of visual epileptic seizures according to their signs and symptoms in adults. PATIENTS AND METHODS:Data were collec...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2015-03-16 00:00:00
abstract：:Parkinson's disease is a neurodegenerative disorder associated with aging characterized by a motor extrapiramidal alteration secondary to the progressive death of dopaminergic neurons of the substantia nigra pars compacta. The cause of this neuronal loss remains unknown but post mortem studies on brains of parkinsonia...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2004-03-16 00:00:00
abstract：OBJECTIVE:To investigate some immune component that could contribute to the pathogenesis of Alzheimer's disease associated with the E280A mutation of the presenilin-1 gene (PS-1). PATIENTS AND METHODS:Serum antibodies against both cardiolipin and beta-amyloid peptides (beta 1-40 and beta 1-42) were quantitated by mean...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-12-16 00:00:00
abstract：INTRODUCTION:The value of the P300 cognitive event-related potential in the diagnosis of Alzheimer subtype neurocognitive disorders is still incipient. Recent studies suggest that combining it with neuropsychological tests by cognitive domains would allow an objective and early characterisation of the cognitive impairm...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：10.33588/rn.7101.2019341
更新日期：2020-07-01 00:00:00
abstract：AIMS:The aim of this study was to carry out a review of the state of the art in the endovascular treatment of carotid disease, taking into account the findings currently available, its indications, the technical aspects linked to the intervention as well as those related to the occupational training of the specialists ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2005-12-16 00:00:00
abstract：INTRODUCTION:In recent years Internet has drastically transformed the world of telecommunications. Questions about whether Internet and the global communication accessibility may be considered as a fundamental aspect in the medicine of today and tomorrow have been brought up. OBJECTIVE:Discuss current and future appli...
journal_title：Revista de neurologia
pub_type：
doi：
更新日期：1998-04-01 00:00:00
abstract：TITLE:Signo del cerebelo blanco (reversal sign). : ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:The object of this study to analyse and compare the efficacy of the classic language tasks (repetition, phonological fluency and lexical decision), for the purpose of identifying the dominant hemisphere for language by means of functional magnetic resonance. SUBJECTS AND METHODS:The three tasks were performa...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-07-16 00:00:00
abstract：INTRODUCTION:Myasthenia gravis is an autoimmune disease of the neuromuscular junction that presents clinically as fluctuating weakness of skeletal muscles, as of the ocular region (myasthenia ocular). AIM:To demonstrate that the sensitivity and specificity of the ice pack test are high, in the differential diagnosis o...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2013-11-01 00:00:00
abstract：INTRODUCTION:Unilateral isolated paralysis of the soft palate is a rare clinical entity. CASE REPORT:We describe the case of a 12 year old girl who presented acute dysphagia, a nasal voice and regurgitation of liquids into the nose. Exploration revealed right velopalatine insufficiency with normal gag reflex and phary...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2003-02-15 00:00:00
abstract：INTRODUCTION AND AIMS:The dysexecutive questionnaire (DEX) has been used to study executive deficits in both clinical samples (both psychiatric and neurological) and non-clinical samples, although agreement on its factorial structure is lacking. The aim of this research is to study that structure in the self-administer...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2012-12-01 00:00:00
abstract：INTRODUCTION:Although visual symptoms of multiple sclerosis (MS) are very frequent, they are rarely related with treatment with interferon. This is the first case reported in the literature of retinopathy associated with subcutaneous interferon beta-1a, and the second related to interferons in MS. CASE REPORT:A 30-yea...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2005-04-16 00:00:00
abstract：TITLE:Polimiositis secundaria a un linfoma no Hodgkin. : ...
journal_title：Revista de neurologia
pub_type： 信件
doi：
更新日期：2017-04-01 00:00:00
abstract：AIMS:The main objective of this study is to describe the different neuropsychological deficits associated to the consumption of 3,4-methylenedioxymethamphetamine (MDMA or 'ecstasy'), as well as the growing evidence that attributes these deficits to the selective axonal damage to serotoninergic cells brought about by th...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2005-07-16 00:00:00
