Multicentric oncocytoma of the lung diagnosed by fine-needle aspiration.

Abstract:

:A 50-yr-old man presented with dyspnea. On chest X-ray, multiple pulmonary nodules were observed. Fine-needle aspiration biopsy (FNAB) showed tridimensional aggregates of atypical round epithelial cells, containing numerous cytoplasmic granules. The tissue fragment confirmed the presence of an epithelial tumor composed of trabecular sheets of clear cells, with numerous cytoplasmic granules which stained with phosphotungstic acid hematoxylin (PTAH). Immunohistochemically, the tumor cells were positive for cytokeratins and antimitochondrial antigen, whereas chromogranin, synaptophysin, S-100 protein, and HMB-45 were negative. Clinical and tomographic studies ruled out any tumor mass elsewhere. The rarity of this lesion in the lung and the potential difficulties for its diagnosis prompted us to report the clinical, cytological, and immunohistochemical findings in this case.

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

Laforga JB,Aranda FI

doi

10.1002/(sici)1097-0339(199907)21:1<51::aid-dc14>3

subject

Has Abstract

pub_date

1999-07-01 00:00:00

pages

51-4

issue

1

eissn

8755-1039

issn

1097-0339

pii

10.1002/(SICI)1097-0339(199907)21:1<51::AID-DC14>3

journal_volume

21

pub_type

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