Effectiveness of fine-needle aspiration cytology of breast: analysis of 2,375 cases from northern Thailand.

Abstract:

:At the Maharaj Nakorn Chiang Mai Hospital, Chiang Mai, Thailand, 2,375 cases of breast lesions were sampled by fine-needle aspiration (FNA) from 1994-1999. Cytologic diagnoses were: benign (48%), suspicious for malignancy (5%), malignant (15%), and unsatisfactory (32%). Comparison with histology was possible in 721 cases. The diagnoses obtained by FNA showed a sensitivity of 84.4%, specificity of 99.5%, positive predictive value of 99.8%, negative predictive value of 84.3%, false-negative rate of 16.7%, false-positive rate of 0.5%, and overall diagnostic accuracy of 91.3%. We conclude that, in experienced hands, FNA of breast masses is reliable for diagnosis. Assessment of samples at the time of aspiration can reduce the number of inadequate specimens to near zero. Correlation of FNA results with clinical and radiologic findings can identify false-negatives and false-positives, ensuring optimal patient management. Many centers now recommend needle core biopsy instead of FNA. For regions such as ours, the added cost of this test would make it unavailable to many patients, which could delay a diagnosis of breast cancer. We advocate keeping FNA as a first-line diagnostic procedure, at least in areas under economic restrictions, in order to maximize the availability of health care to women with breast disease.

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

Chaiwun B,Settakorn J,Ya-In C,Wisedmongkol W,Rangdaeng S,Thorner P

doi

10.1002/dc.10067

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

201-5

issue

3

eissn

8755-1039

issn

1097-0339

pii

10.1002/dc.10067

journal_volume

26

pub_type

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