Abstract:
:Metaplastic cells with nebular cytoplasmic changes in the cervical smear are classified in the Dutch coding system for cervical screening as KOPAC O8 cells. Since these nebulated cells are already documented by Papanicolaou, we refer to these cells as Papanicolaou's nebular cells. We examined the simultaneous presence of these characteristic metaplastic cells and high-grade squamous intraepithelial lesion (HSIL) in a population-based data base from January 1991 and December 1996. The odds ratio (OR) of nebular cells concurring with HSIL increases with age. For the age cohort 30 years, the OR was 7.8 with a 95% confidence interval (CI) of 4.4-13.9. For the age cohort 60 years, the OR was 35.3 with a 95% CI of 7.8-159.2. Aiming to determine the nature of these nebular metaplastic cells, we performed Chlamydia and HPV PCR on 587 and 1,483 smears, respectively. With an OR of 0.9 [0.3-2.4] it is unlikely that Chlamydia plays a role in the appearance of these nebular cells in the smear. This study shows that with an OR of 5.9 [1.7-21.3] HPV is not only related to large koilocytosis but also to a nebular change of small metaplastic cells. This study reports that nebular changes of small metaplastic cells are related to cervical cancer and to HPV infection.
journal_name
Diagn Cytopatholjournal_title
Diagnostic cytopathologyauthors
Roeters AM,Boon ME,van Haaften M,Vernooij F,Bontekoe TR,Heintz APdoi
10.1002/dc.21523subject
Has Abstractpub_date
2012-03-01 00:00:00pages
197-200issue
3eissn
8755-1039issn
1097-0339journal_volume
40pub_type
杂志文章abstract::A series of 85 fine-needle aspiration (FNA) biopsies from orbital space occupying lesions of 82 patients are reviewed. A total of 32 benign lesions and 49 malignant lesions were conclusively diagnosed. In two cases the aspirates were insufficient for diagnosis. Of two cases, which were cytologically suspicious for lym...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20375
更新日期:2006-01-01 00:00:00
abstract::Nodular pseudoangiomatous stromal hyperplasia (PASH) of the breast is rare and often indistinguishable from fibroadenoma, clinically and on aspiration biopsy smears. We report our observations in 10 patients with PASH, evaluated by fine-needle aspiration (FNA) biopsy and core biopsy. We retrospectively reviewed the cl...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20270
更新日期:2005-06-01 00:00:00
abstract::We recently observed numerous microspheroliths consisting of microscopic organized crystalline structures of varying shapes, sizes, and colors in a bile specimen from a 65-yr-old woman obtained directly from the gallbladder during a surgical procedure for cholecystectomy. Detection of microspheroliths could be very us...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.1053
更新日期:2001-04-01 00:00:00
abstract::Metastatic dissemination is the primary cause of death in ovarian cancer (OvCa) patients, and dissemination to pleural and peritoneal effusions is a common clinical event. Effusion samples were collected from 15 OvCa patients. Twenty-six samples were collected prospectively, two were archival, and eight were taken fro...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20279
更新日期:2005-11-01 00:00:00
abstract::Endometrium was obtained by brushing 656 hysterectomy specimens with a MedScand cytobrush (Hollywood, FL) in order to evaluate linking an easy-to-use liquid fixative with brush-sampling of the endometrium, and to determine the fixative's operating characteristics when applied to brush-sampling the endometrium. Liquid-...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0339(199605)14:4<367::AID-DC16>
更新日期:1996-06-01 00:00:00
abstract::The authors report a prospective study on 88 samples of superficial lesions (lymph nodes, skin nodules, and breast tumors), performed by fine-needle aspiration cytology (FNAC) in 74 patients, allowing (i) morphologic analysis combined with immunophenotyping by flow cytometry (FCM) and (ii) a cytogenetic study in 33 ca...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20487
更新日期:2006-07-01 00:00:00
abstract::Despite various reports of BK viral (BKV) DNA sequences or proteins in tumors of the urogenital tract, there has been no study statistically linking infection by this polyoma virus (PV) to tumor development. All PV are potential transforming viruses, the large T-antigen of which interacts with tumor suppressor protein...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20429
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:Current clinical practices are shifting towards utilizing less invasive biopsy techniques, including fine needle aspiration (FNA) and needle core biopsies. If a patient has a suspected hematologic malignancy, a portion of the FNA sample is typically submitted for flow cytometry (FC) analysis, providing valua...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.24417
更新日期:2020-06-01 00:00:00
abstract::The biological behavior of neuroendocrine tumors (NETs) is heterogeneous and differs from that of cholangiocarcinoma, which is the most common malignant tumor of the biliary tree. However, the preoperative diagnosis of NET in the biliary tree is extremely difficult and to our knowledge, diagnosis by brush cytology has...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.24173
更新日期:2019-07-01 00:00:00
abstract::Small-cell carcinoma (SmC) and high-grade non-Hodgkin's lymphoma (NHL) are aggressive neoplasms that require prompt diagnosis and treatment. An immediate diagnosis can be obtained using fine-needle aspiration biopsy (FNAB) material from lymph nodes (LNs), which are clinically or radiologically suspicious for tumor inv...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20116
更新日期:2004-10-01 00:00:00
abstract::This study investigated the role of Papanicolaou (Pap) smears in determining the presence of bacterial vaginosis (BV). Pap results, vaginal Gram stains, signs, symptoms, and wet mounts were evaluated. Vaginal smears for Gram stain and routine Pap smears were collected from 420 consecutive patients. Ninety-three percen...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(sici)1097-0339(199907)21:1<10::aid-dc4>3.
更新日期:1999-07-01 00:00:00
abstract::A case of adrenal cryptococcosis diagnosed by fine-needle aspiration biopsy cytology in a 58-yr-old man is presented. The organisms were easily seen with routine modified Wright stain (Diff-Quik) as variably sized yeasts, some with a brightly eosinophilic capsule. The diagnosis was confirmed with mucicarmine and silve...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840070123
更新日期:1991-01-01 00:00:00
abstract::Differential leukocyte counts on noninflammatory synovial fluids (NISF) are not widely reported or used in research, apparently due to technical difficulties related to either high viscosity or low numbers of cells. We describe an evaluation of a technique using hyaluronidase and cytospin preparations to study NISF. T...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(sici)1097-0339(200004)22:4<256::aid-dc13>
更新日期:2000-04-01 00:00:00
abstract::The diagnostic significance of grooved nuclei in the cytology of extrathyroid lesions is not well-described in the literature. Isolated cases of metastatic adult granulosa cell tumor, reactive mesothelial hyperplasia, Langerhans' cell histiocytosis, recurrent renal cell carcinoma, and round cell liposarcoma were revie...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(sici)1097-0339(199701)16:1<57::aid-dc14>3
更新日期:1997-01-01 00:00:00
abstract::Ovarian gonadoblastoma coexisting with a dysgerminoma is extremely rare in patients with Turner syndrome (TS) and a Y chromosome. The cytological findings, including imprint cytology, of these unusual ovarian tumors have rarely been reported. We report a rare patient with a gonadoblastoma with dysgerminoma, 3.0 × 2.0 ...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章,评审
doi:10.1002/dc.24282
更新日期:2019-11-01 00:00:00
abstract::Mites were observed in 55 pulmonary specimens examined routinely over a 4.5-yr period. The 55 specimens included 33 spontaneous and 12 aerosol-induced sputum samples, nine bronchial washings, and one fine-needle aspirate. Two specimens contained only fragments of mites; however, in most cases the mites were relatively...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840050416
更新日期:1989-01-01 00:00:00
abstract::Since calcific deposits in soft tissue may clinically resemble a tumor, it is feasible to investigate them by fine-needle aspiration (FNA) cytology. In this presentation we describe a case in the breast with extensive accumulation of acellular liquid calcific material which was sampled by the noninvasive technique of ...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(sici)1097-0339(200001)22:1<30::aid-dc9>3.
更新日期:2000-01-01 00:00:00
abstract::Vaginal reconstruction has become an established method to restore sexual function in women who have undergone ultraradical surgery and/or irradiation for the treatment of gynecologic malignancies. Cytologic evaluation of the neovagina serves a major role in the detection of recurrent disease. The purpose of this retr...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840130106
更新日期:1995-07-01 00:00:00
abstract::Ameloblastic fibroma of the jaw is a rare, benign mixed odontogenic tumor, having little tendency for local invasion and a low recurrence rate. Cytologic distinction from ameloblastoma, ameloblastic fibrosarcoma, and intraosseous adenoid cystic carcinoma is necessary, in view of the different biologic behavior. A pain...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.10310
更新日期:2003-08-01 00:00:00
abstract::Sentinel lymph nodes (SLN) isolated in 40 patients of breast carcinoma (stage T(1)/T(2)) were evaluated intraoperatively by imprint cytology and frozen section. Rapid immunohistochemistry (IHC) was done in cases where both imprint smears and frozen sections were negative for any metastatic tumor deposits. The results ...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.21120
更新日期:2009-12-01 00:00:00
abstract::Fine needle aspiration (FNA) has proven to be an effective tool in management of patients with thyroid nodules. However, the diagnosis of follicular patterned lesions can be challenging. The surgical and cytopathology computer database at a large referral medical center was searched for cases that had both cytologic a...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.21477
更新日期:2012-05-01 00:00:00
abstract::Twenty-two women with uterine carcinoma with morphological alterations postradiation treatment suggestive of Chlamydia trachomatis infection were analyzed by direct immunofluorescence. The diagnosis was confirmed in 12 (54.4%) cases. Discussions of the presence of Chlamydia in irradiated cells were not found in the li...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840060203
更新日期:1990-01-01 00:00:00
abstract::Most granulomas of the prostate are nonspecific; infectious, post-operative, and allergic lesions are much less common. Fine-needle aspiration findings in the typical case are distinctive and easily recognized. Several series have been reported, but few have included histologic follow-up. We describe three cases of gr...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840070513
更新日期:1991-01-01 00:00:00
abstract::The diagnosis of melanoma can be challenging, especially in metastatic lesions, due to the ability of melanoma cells to morphologically mimic carcinoma, sarcoma and even lymphoma cells. Moreover, melanomas can exhibit negative immunostaining for the melanoma markers HMB-45 and MART-1/Melan-A, often used in the diagnos...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.22948
更新日期:2013-10-01 00:00:00
abstract::The presence of epithelioid cells in fine-needle aspirations of a liver nodule is rare, but may complicate the diagnosis of the nodule. We report on a case of a liver nodule in hepatitis C cirrhosis. Results of fine-needle aspiration mainly revealed the presence of epithelioid cells, without any recognizable tumor cel...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.1087
更新日期:2001-06-01 00:00:00
abstract::Fine-needle capillary cytology (FNCC) has been attempted in various organs and studies have shown this procedure to yield qualitatively superior material compared with fine-needle aspiration cytology (FNAC). Studies evaluating the efficacy of this technique in lymph nodes are rare. The present study has attempted to a...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.21109
更新日期:2009-11-01 00:00:00
abstract::This study investigates the potential value of the nuclear matrix protein NMP179 as a marker of abnormal squamous cells in ThinPrep slides. Forty-six cervical scrapes were collected as cell suspensions and ThinPrep slides were prepared. They were double-immunostained for NMP179 and Cytokeratin 18 (CK18), an endocervic...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20061
更新日期:2004-09-01 00:00:00
abstract::To avoid contamination of equipment and reduce risks of infection, intraoperative cytology (IOC) is a useful substitute to conventional frozen section in the diagnosis of infectious diseases. One of the various histomorphologic patterns of infections is the granuloma, which sometimes may be difficult to diagnose cytol...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(sici)1097-0339(199801)18:1<62::aid-dc10>3
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Fine-needle aspiration (FNA) is commonly used to investigate lymphadenopathy of suspected metastatic origin. While diagnostic accuracy of FNA for lymph node disease is well described, the relationship between node size, percent tumor replacement, and size of metastatic deposit with diagnostic accuracy is les...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.24617
更新日期:2021-02-01 00:00:00
abstract::Pancreatic metastasis is extremely rare, particularly from small-cell lung cancer (SCLC). Studies on the role of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) with liquid-based cytology (LBC) in the diagnosis of metastatic small-cell carcinoma in the pancreas have been rarely conducted. We report herei...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.23990
更新日期:2018-11-01 00:00:00