Abstract:
:This review summarizes current knowledge about the role of nitric oxide (NO) in cystic fibrosis (CF) lung disease. NO is endogenously produced by a group of enzymes, the NO synthases (NOSs). There are three isoforms of NOS, each encoded by different genes: neuronal (nNOS), immune or inducible (iNOS), and endothelial (eNOS) nitric oxide synthase.(1) They all form NO and L-citrulline by enzymatic oxidation of L-arginine. This reaction requires a number of cosubstrates, including molecular oxygen and tetrahydrobiopterin. It is now known whether all three isoenzymes are constitutively expressed in cells of the respiratory tract and that their gene expression is inducible.(2,3) NO production by iNOS, the "high-output" NOS, is stimulated by bacterial lipopolysaccharide (LPS) as well as proinflammatory cytokines such as interleukin (IL)-1gamma, IL-2, interferon (IFN)-gamma, and tumor necrosis factor (TNF). In contrast to nNOS and eNOS, activation of iNOS does not require an increase in intracellular Ca(2+) concentration.
journal_name
Pediatr Pulmonoljournal_title
Pediatric pulmonologyauthors
Grasemann H,Ratjen Fdoi
10.1002/(sici)1099-0496(199912)28:6<442::aid-ppul1subject
Has Abstractpub_date
1999-12-01 00:00:00pages
442-8issue
6eissn
8755-6863issn
1099-0496pii
10.1002/(SICI)1099-0496(199912)28:6<442::AID-PPUL1journal_volume
28pub_type
杂志文章,评审abstract::Thirteen children with asthma were treated with cumulative doses of terbutaline delivered as a pressurized aerosol and from a new multidose powder inhaler (Turbuhaler) in a randomized cross-over dose-response study. The cumulative dose of terbutaline was 2 mg on each study day. All children used a correct aerosol inha...
journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/ppul.1950070211
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Plastic bronchitis (PB) is a rare, variable, and potentially fatal disease. This study aimed to assess the efficacy of fiberoptic bronchoscopy (FOB) and bronchoalveolar lavage (BAL) in treating children with PB. METHODS:In total, 15 children with PB, between 2012 and 2020, were enrolled in our study. Within...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.25016
更新日期:2020-11-01 00:00:00
abstract::Neurally adjusted ventilatory assistance (NAVA) can overcome technical difficulties with synchronizing noninvasive ventilation breaths with the patient, a modality often used in very low birthweight infants (VLBW) with apnea of prematurity (AOP). This study is a retrospective single-center investigation into whether N...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.24464
更新日期:2019-11-01 00:00:00
abstract::Home mattresses of 24 asthmatic children with house dust mite allergy were sprayed with either benzyl-benzoate foam or placebo in a double blind fashion, 10 days before the children left the residential house for asthmatic children Istituto Pio XII (located in the Italian Alps in an environment free of mites) and went...
journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/ppul.1950180405
更新日期:1994-10-01 00:00:00
abstract::While many factors that contribute to the occurrence of lower respiratory tract infections (LRTI) in Canadian indigenous children have been described, the role of aspiration during swallowing has not been explored in these children. Because of an increase in referrals of indigenous children from our catchment area (Ma...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.21489
更新日期:2011-12-01 00:00:00
abstract::Foreign-body aspiration (FBA) is a commonly encountered serious problem during childhood, accounting for 7% of lethal accidents in children aged 1-3 years. Bronchoscopy is indicated when a clear history of FBA is present, but the history may be unreliable. Clinical manifestations can be seen in various diseases, and w...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20128
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVES:We assessed the performance of a tracheostomy decannulation protocol privileging safety over quickness, in pediatric patients undergoing rehabilitation from severe acquired brain injury. We analyzed factors associated with decannulation timing and possibility and examined cases of failure. HYPOTHESIS:A safe...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.23832
更新日期:2017-11-01 00:00:00
abstract::The incidence of empyema complicating community-acquired pneumonia is increasing and causes significant childhood morbidity. Pneumococcal infection remains the most common isolated cause in developed countries, with Staphylococcus aureus the predominant pathogen in the developing world. Newer molecular techniques util...
journal_title:Pediatric pulmonology
pub_type: 杂志文章,评审
doi:10.1002/ppul.20251
更新日期:2005-08-01 00:00:00
abstract::Eight patients with cystic fibrosis [CF] colonized with Pseudomonas aeruginosa (P. aeruginosa) had serial lung function, peripheral blood inflammatory markers, and serum IgG antibodies to Burkholderia cepacia (B. cepacia) lipopolysaccharide measured in the months preceding and following colonisation with B. cepacia. O...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/(sici)1099-0496(200001)29:1<8::aid-ppul2>3
更新日期:2000-01-01 00:00:00
abstract::A new method that permits the measurement of adult-type maximal expiratory flow-volume curves and fractional lung volumes in sedated infants was recently described. The purpose of this study was to define the normal range for these new measures of pulmonary function in infants and young children. Measurements of force...
journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章
doi:10.1002/1099-0496(200009)30:3<215::aid-ppul6>3.0.c
更新日期:2000-09-01 00:00:00
abstract::Tracheoesophageal fistula (TEF) with esophageal atresia (EA) is a common congenital anomaly that is associated with significant respiratory morbidity throughout life. The objective of this document is to provide a framework for the diagnosis and management of the respiratory complications that are associated with the ...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.24982
更新日期:2020-10-01 00:00:00
abstract::This paper assesses the effectiveness of aerosolized tobramycin (TOBI) on cystic fibrosis (CF) lung disease, using a radiologic tool. The published tool, the age-based severity curve (ABS), is derived from Brasfield scoring of chest X-rays (CXR). This study evaluates both the usefulness of the ABS as an assessment too...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20032
更新日期:2004-07-01 00:00:00
abstract::In adults abdominal obesity is related to lung dysfunction and waist circumference (WC) predicts pulmonary function. It is not known how WC affects pulmonary function in children. A cross-sectional study of 718 children 6-17 years of age was conducted in a rural community to determine the predictability of WC for pulm...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20854
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:In 1995 the Tucson Children's Respiratory Study (TCRS) identified clinically distinct phenotypes amongst early wheezers; the Avon Longitudinal Study of Parents And Children (ALSPAC) has recently re-examined these. OBJECTIVES:To validate statistically derived ALSPAC phenotypes in the Southampton Women's Surv...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.22766
更新日期:2013-07-01 00:00:00
abstract::Lane-Hamilton syndrome refers to the uncommon co-occurrence of idiopathic pulmonary hemosiderosis and celiac disease (CD). Three children aged between 7 and 14 years with IPH were detected to have co-existing non-diarrheal CD. Institution of gluten-free diet in each of the three children resulted in amelioration of th...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.21357
更新日期:2011-03-01 00:00:00
abstract::The goal of this research was to begin the process of evaluating acceptability of infection control (IC) recommendations to CF patients and their families, determine whether compliance with IC guidelines differs from compliance with traditional CF medical treatment with respect to the variables predictive of complianc...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20781
更新日期:2008-05-01 00:00:00
abstract::Until the year 2000, systematic cystic fibrosis (CF) neonatal screening was only performed in a few regions of France. The Brittany region began in 1989, but not the neighboring region of Loire-Atlantique. The present study compares the clinical evolution of both affected populations 10 years after screening was start...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.10259
更新日期:2003-05-01 00:00:00
abstract::Sleep disordered breathing (SDB) represents a spectrum of breathing disorders, ranging from snoring to obstructive sleep apnea syndrome (OSAS), that disrupt nocturnal respiration and sleep architecture. OSAS is a common disorder in children, with a prevalence of 2-3%. It is associated with neurobehavioral, cognitive, ...
journal_title:Pediatric pulmonology
pub_type: 杂志文章,评审
doi:10.1002/ppul.20943
更新日期:2008-12-01 00:00:00
abstract::The cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), and intercellular adhesion molecule-1 (ICAM-1) have important roles in regulating neutrophil migration and the inflammatory response. To determine whether the concentration of these cytokines and soluble ICAM-1 (sICAM-1) in sputum was increas...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/(SICI)1099-0496(199601)21:1<11::AID-PPUL2>
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Pneumonia is a leading killer of children under-5 years, with a high burden in Nigeria. We aimed to quantify the regional burden and risks of pediatric pneumonia in Nigeria, and specifically the states of Lagos and Jigawa. METHODS:We conducted a scoping literature search for studies of pneumonia morbidity a...
journal_title:Pediatric pulmonology
pub_type: 杂志文章,评审
doi:10.1002/ppul.24626
更新日期:2020-06-01 00:00:00
abstract::Progressive lung disease in patients with cystic fibrosis (CF) is caused by thick secretions, which cause airway obstruction and subsequent colonization and infection by inhaled pathogenic microorganisms. Recently, recombinant human DNase has been shown to reduce the viscoelasticity of sputum in patients with cystic f...
journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/(SICI)1099-0496(199602)21:2<77::AID-PPUL3>
更新日期:1996-02-01 00:00:00
abstract::The jet nebulizer is a common device used for administering aerosol medication in young children. However, compared to a metered dose inhaler-spacer (MDI-spacer), it takes more time and personnel. This study aimed to compare the efficacy of salbutamol aerosol therapy given via these two devices in young wheezing child...
journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/ppul.20204
更新日期:2005-05-01 00:00:00
abstract::Respiratory inductive plethysmography (RIP) is a simple technique for an objective, noninvasive assessment of thoracoabdominal asynchrony, which in turn is an indirect measure of airway obstruction. We evaluated different indices of asynchrony obtained by RIP before and after methacholine-induced airway obstruction. B...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1950200610
更新日期:1995-12-01 00:00:00
abstract::We developed a simple method to identify neonates at high risk of bronchopulmonary dysplasia (BPD) and determined whether early (8 hours) and late (14 days) risk assessment is equally useful. A retrospective cohort design was utilized of subjects enrolled in multi-dose surfactant trials to develop each risk identifica...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/(SICI)1099-0496(199606)21:6<345::AID-PPUL1
更新日期:1996-06-01 00:00:00
abstract::Pneumocyte apoptosis is implicated in the pathophysiology of acute inflammatory lung injuries in newborns and adults. Pulmonary angiotensin (ANG) II contributes to lung epithelial apoptosis in vitro, but its role in acute lung injury in vivo is unclear. We therefore studied the effects of ANG II receptor action on the...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20187
更新日期:2005-04-01 00:00:00
abstract::Bronchial responsiveness to isocapnic hyperventilation with cold air (CAH) and to inhaled methacholine (MCH) was compared in 17 children with bronchial asthma. The response to cold air was expressed as the percent drop in FEV1 from baseline at 4 min. after the challenge (delta % FEV1 CAH), and the response to methacho...
journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章
doi:10.1002/ppul.1950190603
更新日期:1995-06-01 00:00:00
abstract::Pneumatoceles and bronchiectasis are secondary complications of respiratory infections in patients with hyper IgE syndrome (HIgES). We report on a patient with HIgES and recurrent pneumonias since 1 year of age, with progression to pneumatoceles and bronchiectasis and fatal outcome, with disseminated infection and sus...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.22532
更新日期:2013-01-01 00:00:00
abstract::Cystic fibrosis (CF) patients with advanced lung disease are at risk for developing pulmonary vascular disease and pulmonary hypertension, characterized by progressive exercise intolerance beyond the exercise-limiting effects of airways disease in CF. We report on a patient with severe CF lung disease who experienced ...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20393
更新日期:2006-04-01 00:00:00
abstract::Lung transplantation in childhood is a highly specialized clinical practice confined to a few centers around the world. Organ availability remains an important limiting factor in extending the application of this procedure to more infants, children and adolescents. The lungs are the organ most vulnerable to injury, in...
journal_title:Pediatric pulmonology
pub_type: 杂志文章,评审
doi:10.1002/ppul.20997
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVES:To identify the spirometric equations that are most appropriate for use in children and adolescents living in Bogota, Colombia after evaluating a set of relevant previously-developed equations, including the Global Lung Function Initiative (GLI) 2012 spirometry reference equations. METHODS:Healthy children ...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.24331
更新日期:2019-06-01 00:00:00