当前位置： SCI文献检索 > DIABETES RESEARCH AND CLINICAL PRACTICE期刊下所有文献 > High glucose inhibits effect of ascorbic acid on [35S] sulphate incorporation in mesangial cell and matrix proteoglycan.

High glucose inhibits effect of ascorbic acid on [35S] sulphate incorporation in mesangial cell and matrix proteoglycan.

Abstract：

:Expansion of the glomerular mesangium is a consistent finding of diabetic nephropathy. Negatively charged proteoglycans are an integral part of the mesangium and their synthesis and degradation is disturbed in many forms of glomerulosclerosis. The metabolism of ascorbic acid (AA), which plays an important role in extracellular matrix regulation, is known to be abnormal in diabetes. The action of AA has also been shown to be inhibited by high glucose (HG) concentration. In this study we investigated the effect of AA and HG on proteoglycan (PG) synthesis by examining the incorporation of [35S] sulphate into PG in the cellular, matrix and media components of rat mesangial cell (MC) cultures. MC were grown in 9 or 25 mM glucose for 8 days, with and without the addition of AA. Sulphation of PG was measured by adding 50 microCi of [35S] sulphuric acid to the culture medium and precipitating 35S-labelled PG with cetylpyridinium chloride. In this study AA was shown to have a stimulatory effect on the overall incorporation of [35S] sulphate into cell and matrix PG and this was inhibited by 25 mM glucose. Correcting for protein synthesis and specific activity of [35S] sulphate showed that HG inhibits AA stimulation by decreasing sulphation of the individual PG molecules. These findings may be of particular importance in the pathophysiology of nephropathy in diabetes, a condition where AA concentration is already compromised.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

McAuliffe AV,Fisher EJ,McLennan SV,Yue DK,Turtle JR

doi

10.1016/s0168-8227(97)00063-6

subject

Has Abstract

pub_date

1997-08-01 00:00:00

pages

101-8

issue

2

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(97)00063-6

journal_volume

37

pub_type

杂志文章

相关文献

DIABETES RESEARCH AND CLINICAL PRACTICE文献大全
  • A systematic review, meta-analysis, and meta-regression of the impact of diurnal intermittent fasting during Ramadan on glucometabolic markers in healthy subjects.

    abstract：AIM:Studies on the effect of Ramadan diurnal intermittent fasting (RDIF) on glucometabolic markers have yielded conflicting results. We conducted ameta-analysis to estimate the effect size for changes in glucometabolic markers in healthy, non-athletic Muslims during Ramadan, and to assess the effect of variable covaria...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.diabres.2020.108226

    authors： Faris MA,Jahrami H,BaHammam A,Kalaji Z,Madkour M,Hassanein M

    更新日期：2020-07-01 00:00:00

  • Community-based population data indicates the significant alterations of insulin resistance, chronic inflammation and urine ACR in IFG combined IGT group among prediabetic population.

    abstract：AIMS:To investigate alterations of insulin resistance (IR), chronic inflammation and urine albumin-to-creatinine ratio (ACR) in Chinese community-based prediabetic population. MATERIALS AND METHODS:252 prediabetics [prediabetes (PD), including impaired fasting glucose (IFG), 91; impaired glucose tolerance (IGT), 123; ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2009.03.002

    authors： Lü Q,Tong N,Liu Y,Li N,Tang X,Zhao J,Cao H,Li D,Gou L,Zhang Y,Wan J,Jiang L

    更新日期：2009-06-01 00:00:00

  • Carbohydrate metabolism and cardiovascular risk factors 4 years after a pregnancy complicated by gestational diabetes.

    abstract：AIMS:The aim of the present study was to determine the prevalence of abnormal glucose tolerance and the metabolic syndrome in a cohort of previously gestational diabetic (GDM) women 4 years after delivery. METHODS:Sixty-eight prior GDM and a control group of 39 women with normal glucose tolerance during pregnancy were...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2009.05.001

    authors： Madarász E,Tamás G,Tabák AG,Kerényi Z

    更新日期：2009-08-01 00:00:00

  • A renal genetic risk score (GRS) is associated with kidney dysfunction in people with type 2 diabetes.

    abstract：:This study aims to investigate whether renal and cardiovascular phenotypes in Italian patients with type 2 diabetes (T2D) could be influenced by a number of disease risk SNPs recently found in genome-wide association studies (GWAS). In 1591 Italian subjects with T2D: (1) 47 SNPs associated to kidney function and/or ch...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2018.08.013

    authors： Zusi C,Trombetta M,Bonetti S,Dauriz M,Boselli ML,Trabetti E,Malerba G,Penno G,Zoppini G,Bonora E,Solini A,Bonadonna RC

    更新日期：2018-10-01 00:00:00

  • Diabetes-related renal growth and IGF-I accumulation in castrated rats.

    abstract：:The effects of castration on diabetes-related renal growth and IGF-I regulation were studied. In the rat, prepubertal castration is associated with a normal or increased surge in plasma insulin-like growth factor I (IGF-I) at the time of 'puberty'. In order to determine the role of sex steroids in the development of d...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/0168-8227(91)90048-i

    authors： Bach LA,Cox AJ,Jerums G

    更新日期：1991-10-01 00:00:00

  • Incidence of children with slowly progressive form of type 1 diabetes detected by the urine glucose screening at schools in the Tokyo Metropolitan Area.

    abstract：:We investigated the incidence of the slowly progressive form of type 1 diabetes (SPT1D) detected by the urine glucose-screening tests at schools in the Tokyo Metropolitan Area from 1974 to 2004. During this study period, a total of 9,242,259 school students underwent the screening program. Of them, 54 children, 19 mal...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.diabres.2008.01.029

    authors： Urakami T,Suzuki J,Yoshida A,Saito H,Mugishima H

    更新日期：2008-06-01 00:00:00

  • A 15 year follow-up study of patients with non-insulin dependent diabetes mellitus (NIDDM) in Osaka, Japan. Long-term prognosis and causes of death.

    abstract：:A 15 year follow-up study of diabetic patients was performed in Osaka, Japan. The subjects studied were 1939 patients with non-insulin dependent diabetes mellitus (NIDDM), of whom 1000 (51.5%) were alive, 880 (45.4%) had died and 59 (3.0%) were untraceable at the end of 1993. The mortality rate per 1000 person-years o...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(96)01329-0

    authors： Sasaki A,Uehara M,Horiuchi N,Hasegawa K,Shimizu T

    更新日期：1996-09-01 00:00:00

  • A novel imaging platform for non-invasive screening of abnormal glucose tolerance.

    abstract：:Optical measurement of skin auto-fluorescence (SAF), most likely emanating from accumulated advanced glycation end-products (AGEs), has been proposed for the noninvasive diagnosis of glucose intolerance in clinical settings. Here, we developed a novel imaging system with transmission geometry for SAF measurement and c...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2016.03.014

    authors： Jeong B,Jung CH,Lee YH,Shin IH,Kim H,Bae SJ,Lee DS,Kang ES,Kang U,Kim JJ,Park JY

    更新日期：2016-06-01 00:00:00

  • The prognostic value of albuminuria for the development of cardiovascular disease and retinopathy: a 5-year follow-up of 451 patients with type 2 diabetes mellitus.

    abstract：:The aim of the present study was to evaluate the risk for vascular morbidity or death and retinopathy in relation to urinary albumin concentration. To that end, we performed a 5-year follow-up study of all type 2 diabetic patients attending the outpatient-clinic. A total of 444 (98.4%) out of 451 adult patients initia...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/0168-8227(96)01218-1

    authors： Agardh CD,Agardh E,Torffvit O

    更新日期：1996-04-01 00:00:00

  • Introduction of diabetes passports involving both patients and professionals to improve hospital outpatient diabetes care.

    abstract：AIM:To investigate whether a comprehensive strategy involving both patients and professionals, with the introduction of a diabetes passport as a key component, improves diabetes care. METHODS:The first 150 consecutive patients who visited their internist for a diabetes check up at the internal medicine outpatient depa...

    journal_title：Diabetes research and clinical practice

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.diabres.2004.09.020

    authors： Dijkstra RF,Braspenning JC,Huijsmans Z,Akkermans RP,van Ballegooie E,ten Have P,Casparie T,Grol RP

    更新日期：2005-05-01 00:00:00

  • miR-221-3p and miR-222-3p downregulation promoted osteogenic differentiation of bone marrow mesenchyme stem cells through IGF-1/ERK pathway under high glucose condition.

    abstract：OBJECTIVE:This study aims to investigate the roles of miR-221-3p and miR-222-3p in the regulation of osteogenic differentiation of bone marrow mesenchyme stem cells (BMSCs) under high glucose condition. MATERIALS AND METHODS:The expreesions of miR-221-3p, miR-222-3p and insulin-like growth factor 1 (IGF-1) were detect...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2020.108121

    authors： Gan K,Dong GH,Wang N,Zhu JF

    更新日期：2020-09-01 00:00:00

  • Strong association of common variants in the IGF2BP2 gene with type 2 diabetes in Lebanese Arabs.

    abstract：OBJECTIVE:Several genome-wide association studies and replication analyses have identified common variation at the insulin-like binding protein 2 (IGF2BP2) gene to be associated with type 2 diabetes (T2DM). The aim of this study was to replicate in a Lebanese Arab population identified associations of IGF2BP2 variants ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2011.12.026

    authors： Nemr R,Echtay A,Dashti EA,Almawi AW,Al-Busaidi AS,Keleshian SH,Irani-Hakime N,Almawi WY

    更新日期：2012-05-01 00:00:00

  • Blood glucose and nocturnal blood pressure in African and Caucasian men: The SABPA study.

    abstract：AIM:To investigate the relationship between nocturnal blood pressure and chronically elevated blood glucose to determine if these elevated blood glucose concentrations contribute to a non-dipping blood pressure, especially in high-risk groups such as Africans. METHODS:Nocturnal blood pressures and blood glucose levels...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2011.05.011

    authors： Lammertyn L,Schutte AE,Schutte R

    更新日期：2011-08-01 00:00:00

  • Association between QTc interval prolongation and outcomes of diabetic foot ulcers: Data from a 4-year follow-up study in China.

    abstract：OBJECTIVES:To examine whether QTc interval prolongation is an independent risk factor of outcomes in patients with diabetic foot ulcers (DFU). RESEARCH DESIGN AND METHODS:331 patients with type 2 diabetes and DFU hospitalized in a Chinese tertiary hospital were recruited. ECG was done at baseline and QTc interval was ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2018.01.021

    authors： Wang S,He Y,Xu L,Zhang S,Gu X,Gu J,Shi J,Shen Y,Tang Z

    更新日期：2018-04-01 00:00:00

  • Effect of moderate-intensity exercise training on GDNF signaling pathway in testicles of rats after experimental diabetes type 1 induction.

    abstract：AIMS:The spermatogenesis failure is reported as the main complication for diabetes and the moderate-intensity exercise (EX) is shown to ameliorate the diabetes-induced impairments both at spermatogenesis and sperm levels. Thus, the current study was done to investigate the possible effect of EX in the sole and simultan...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2020.108332

    authors： Samadian Z,Tofighi A,Razi M,Ghaderi Pakdel F,Tolouei Azar J

    更新日期：2020-09-01 00:00:00

  • Impaired metabolism-secretion coupling in pancreatic beta-cells: role of determinants of mitochondrial ATP production.

    abstract：:Glucose-induced insulin secretion from beta-cells is often impaired in diabetic condition and by exposure to diabetogenic pharmacological agents. In pancreatic beta-cells, intracellular glucose metabolism regulates exocytosis of insulin granules, according to metabolism-secretion coupling in which glucose-induced mito...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,评审

    doi：10.1016/j.diabres.2007.01.026

    authors： Fujimoto S,Nabe K,Takehiro M,Shimodahira M,Kajikawa M,Takeda T,Mukai E,Inagaki N,Seino Y

    更新日期：2007-09-01 00:00:00

  • Different effects of growth hormone on growth and function of isolated adult and fetal rat pancreatic islets.

    abstract：:We simultaneously determined 3H-thymidine incorporation, DNA content, and insulin biosynthesis in adult and fetal rat pancreatic islets. 3H-thymidine incorporation was measured after tissue solubilization. DNA was measured fluorometrically. Insulin biosynthesis was determined through 3H-leucine incorporation after imm...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(88)80053-6

    authors： Sieradzki J,Chatterjee AK,Fleck E,Schatz H

    更新日期：1988-07-13 00:00:00

  • Predictors of quality of life gains among people with type 1 diabetes participating in the Dose Adjustment for Normal Eating (DAFNE) structured education programme.

    abstract：AIMS:To examine predictors of quality of life gains among people with type 1 diabetes following the Dose Adjustment for Normal Eating (DAFNE) self-management training programme. METHODS:Clinical and questionnaire data were collected from 437 patients from 6 hospital centres before, and 18 months post-DAFNE interventio...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2012.09.017

    authors： Byrne M,Newell J,Coffey N,O' Hara MC,Cooke D,Dinneen SF

    更新日期：2012-11-01 00:00:00

  • Subcutaneous antihistamine injection is effective to control a local allergic reaction to human insulin.

    abstract：:A 31-year-old woman, having a type-1 diabetes and an insulin allergy, was successfully treated with a subcutaneous antihistamine injection to the next continuous subcutaneous insulin infusion site. ...

    journal_title：Diabetes research and clinical practice

    pub_type： 信件

    doi：10.1016/j.diabres.2009.05.013

    authors： Imakado S,Hamada K,Atsumi Y

    更新日期：2009-09-01 00:00:00

  • Adherence to postpartum diabetes mellitus screening, do associated pregnancy complications make a difference?

    abstract：AIMS:We aimed to investigate the impact of Gestational Diabetes Mellitus (GDM) complications on compliance with postpartum Diabetes screening. METHODS:A retrospective cohort study was conducted comparing screening rates of women with and without GDM associated complications who delivered at the Soroka University Medic...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2019.107972

    authors： Rotem R,Salem-Yaniv S,Sandler-Rahat H,Yohay D,Sade S,Yahav L,Weintraub AY

    更新日期：2020-01-01 00:00:00

  • Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes.

    abstract：:It is recognized that a chronic low-grade inflammation and an activation of the immune system are involved in the pathogenesis of obesity-related insulin resistance and type 2 diabetes. Systemic inflammatory markers are risk factors for the development of type 2 diabetes and its macrovascular complications. Adipose ti...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,评审

    doi：10.1016/j.diabres.2014.04.006

    authors： Esser N,Legrand-Poels S,Piette J,Scheen AJ,Paquot N

    更新日期：2014-08-01 00:00:00

  • Reclassification of diabetes type in pediatric patients initially classified as type 2 diabetes mellitus: 15 years follow-up using routine data from the German/Austrian DPV database.

    abstract：OBJECTIVE:To examine change of diagnosis in patients from the German/Austrian multicenter DPV (Diabetes Patienten Verlaufsdokumentation) database initially classified as type 2 diabetes. METHODS:Patients aged ≤20 years at onset, diagnosed between 1995 and 2010 were followed for at least 6 months. Chi-square/Wilcoxon t...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.diabres.2011.09.011

    authors： Awa WL,Schober E,Wiegand S,Herwig J,Meissner T,Schmidt F,Molz E,Holl RW

    更新日期：2011-12-01 00:00:00

  • Optimal range of HbA1c for the prediction of future diabetes: a 4-year longitudinal study.

    abstract：AIM:A glycated hemoglobin (HbA1c) range of 5.7-6.4% has been included as a category of increased risk for diabetes. We evaluated whether or not it is reasonable to apply this HbA1c range to Koreans. METHODS:A retrospective analysis was conducted among subjects who participated in comprehensive health check-ups annuall...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2011.05.028

    authors： Bae JC,Rhee EJ,Lee WY,Park SE,Park CY,Oh KW,Park SW,Kim SW

    更新日期：2011-08-01 00:00:00

  • A new, improved test system for rapid measurement of blood glucose.

    abstract：:Several models of blood glucose meters are available to diabetic patients. They all require several steps for their operation, which increases the potential for user error. A new meter (One Touch TM System, Lifescan Inc., a Johnson & Johnson Company, Mountain View, CA) was designed to minimise the operational steps an...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/0168-8227(89)90045-4

    authors： Hunt JA,Alojado NC

    更新日期：1989-06-20 00:00:00

  • Hyperglycemia: still an important predictor of adverse outcomes following AMI in the reperfusion era.

    abstract：:Hyperglycemia in patients admitted to hospital with myocardial infarction has been associated with adverse outcomes. However, with the improvements in survival seen in the reperfusion era, the glycometabolic state of patients presenting with acute myocardial infarction (AMI) is often given a low priority. The aim of t...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2003.10.016

    authors： Wong VW,Ross DL,Park K,Boyages SC,Cheung NW

    更新日期：2004-05-01 00:00:00

  • Risk factors associated with the progression of COVID-19 in elderly diabetes patients.

    abstract：AIM:To describe the clinical characteristics and risk factors associated with the progression of COVID-19 in elderly diabetes patients. METHODS:This was a retrospective cohort study, including elderly COVID-19 patients admitted to Wuhan Huoshenshan Hospital between February 10 and 13, 2020. Demographic data, medical h...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2020.108550

    authors： Zhang P,Wang M,Wang Y,Wang Y,Li T,Zeng J,Wang L,Li C,Gong Y

    更新日期：2020-11-21 00:00:00

  • Function of hormone-sensitive lipase in diacylglycerol-protein kinase C pathway.

    abstract：:To explore the functional effects of hormone-sensitive lipase (HSL) in diacylglycerol (DAG) metabolism, Chinese hamster ovary cells were stably transfected with rat HSL cDNA (wt-HSL), inactive mutant S423A-HSL cDNA (S423A) and pcDNA3 vector alone (Ct). [(14)C]Glucose-incorporation into triglyceride (TG) was 75% lower ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2004.02.006

    authors： Kanehara H,Suzuki J,Zenimaru Y,Takahashi S,Oida K,Shen WJ,Kraemer FB,Miyamori I

    更新日期：2004-09-01 00:00:00

  • Country of birth modifies the association of fatty liver index with insulin action in Middle Eastern immigrants to Sweden.

    abstract：AIMS:Non-alcohol fatty liver disease (NAFLD) is a strong risk factor for insulin resistance and type 2 diabetes. The prevalence of NAFLD varies across populations of different ethnic backgrounds but the prevalence in Middle Eastern populations, which are at high risk of type 2 diabetes, is largely unknown. Using fatty ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2015.07.011

    authors： Bennet L,Groop L,Franks PW

    更新日期：2015-10-01 00:00:00

  • The effect of short-term basal insulin supplementation with human ultralente insulin on diurnal glycemic control in NIDDM patients.

    abstract：:The effect of short-term insulin treatment with a long-acting insulin preparation, Ultratard HM (U-HM) was investigated in eight non-insulin-dependent diabetes mellitus (NIDDM) patients whose previous glycemic control using diet was judged unsatisfactory. The treatment consisted of one daily pre-breakfast injection of...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(87)80058-x

    authors： Iwamoto Y,Matsuda A,Sakamoto Y,Kuzuya T

    更新日期：1987-11-01 00:00:00

  • Glucose "peak" and glucose "spike": Impact on endothelial function and oxidative stress.

    abstract：AIM:Data suggest that 2h hyperglycaemia during an OGTT is less predictive for cardiovascular disease of the glucose "spike" (the difference between the baseline glucose level and the "peak" hyperglycaemia during the test). METHODS:A euinsulinemic hyperglycaemic clamp at 10 and 15mmol/l glucose, with or without vitamin...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2008.07.015

    authors： Ceriello A,Esposito K,Piconi L,Ihnat M,Thorpe J,Testa R,Bonfigli AR,Giugliano D

    更新日期：2008-11-01 00:00:00