alpha 1-adrenoceptor stimulation is able to reverse halothane-induced cardiac depression in isolated rat hearts.

Abstract:

BACKGROUND:Stimulation of myocardial alpha 1-adrenoceptors has been shown to exert positive inotropic effects through a cyclic AMP-independent mechanism. The purpose of this study was to examine if alpha 1-adrenoceptor stimulation is able to attenuate myocardial depression produced by exposure to halothane, and to test if alpha 1-adrenoceptor stimulation alters myocardial oxygen supply-demand balance in hearts exposed to halothane. METHODS:The effects of phenylephrine were examined in 7 isolated perfused rat hearts. Variables measured were: heart rate, isovolumetric peak left ventricular pressure (LVP), LV dP/dt, coronary arterial flow, myocardial O2 delivery (DO2), myocardial O2 consumption (MVO2) and the ratio of DO2/MVO2. Each heart was exposed to phenylephrine cumulatively 0.1 microM, 0.3 microM, 1 microM and 3 microM under the administration of 1% halothane in the presence of propranolol 1 microM. RESULTS:Halothane 1% decreased the heart rate by 9 +/- 3%, LVP by 37 +/- 3%, and LV dP/dt by 35 +/- 2%. Phenylephrine restored these decreases to the baseline levels. Phenylephrine maintained or further enhanced the reductions in coronary flow and DO2 produced by halothane, resulting in a decrease in the DO2/ MVO2 ratio. CONCLUSION:alpha 1-adrenoceptor stimulation is capable of restoring direct cardiac depressant effects of halothane with a possible impairment of the oxygen supply-demand balance.

authors

Okuyama T,Hoka S,Okamoto H,Kawasaki T,Yamaura K,Takahashi S

doi

10.1111/j.1399-6576.1997.tb04812.x

subject

Has Abstract

pub_date

1997-08-01 00:00:00

pages

939-44

issue

7

eissn

0001-5172

issn

1399-6576

journal_volume

41

pub_type

杂志文章
  • Post-void residual volume in labor: a prospective study comparing parturients with and without epidural analgesia.

    abstract:BACKGROUND:This prospective, non-randomized study compared post-void residual volume in laboring and postpartum women with or without epidural analgesia. METHODS:The study was conducted over 1 year with institutional review board approval. Parturients were recruited in early labor and self-selected to either the study...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2006.01122.x

    authors: Weiniger CF,Wand S,Nadjari M,Elchalal U,Mankuta D,Ginosar Y,Matot I

    更新日期:2006-11-01 00:00:00

  • Studies on fluid extravasation related to induced hypothermia during cardiopulmonary bypass in piglets.

    abstract:BACKGROUND:Hypothermia, commonly used for organ protection during cardiopulmonary bypass (CPB), has been associated with changes in plasma volume, hemoconcentration and microvascular fluid shifts. Fluid pathophysiology secondary to hypothermia and the mechanisms behind these changes are still largely unknown. In a rece...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2001.045006720.x

    authors: Heltne JK,Koller ME,Lund T,Farstad M,Rynning SE,Bert JL,Husby P

    更新日期:2001-07-01 00:00:00

  • Does colloid-induced plasma hyperviscosity in haemodilution jeopardize perfusion and oxygenation of vital organs?

    abstract:BACKGROUND AND METHODS:The infusion of dextran solutions is associated with haemodilution and, under some conditions, with a slight increase in plasma viscosity. To clarify the compound effects of simultaneous haemodilution and plasma viscosity increases on macro- and microhaemodynamics, we investigated the changes in ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1995.tb04050.x

    authors: Krieter H,Brückner UB,Kefalianakis F,Messmer K

    更新日期:1995-02-01 00:00:00

  • Prophylactic and delayed treatment with high-dose methylprednisolone in a porcine model of early ARDS induced by endotoxaemia.

    abstract::The effects of prophylactic and delayed treatment with high-dose methylprednisolone were evaluated in a porcine model of early adult respiratory distress syndrome induced by endotoxaemia. Spontaneously breathing pigs under ketamine anaesthesia were infused i.v. with E. coli endotoxin (10 micrograms . h-1 . kg-1) over ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1985.tb02307.x

    authors: Borg T,Gerdin B,Modig J

    更新日期:1985-11-01 00:00:00

  • Recovery from sufentanil anaesthesia for outpatient arthroscopy: a comparison with isoflurane.

    abstract::This study compares the recovery from sufentanil and isoflurane anaesthesia in patients undergoing outpatient arthroscopy of the knee under general anaesthesia. In 40 unpremedicated patients, divided at random into two groups, anaesthesia was induced with methohexitone and vecuronium bromide and, after intubation, mai...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1987.tb02539.x

    authors: Zuurmond WW,van Leeuwen L

    更新日期:1987-02-01 00:00:00

  • Stroke volume variation does not predict fluid responsiveness in patients with septic shock on pressure support ventilation.

    abstract:BACKGROUND:Stroke volume variation (SVV)--as measured by the pulse contour cardiac output (PiCCO) system--predicts the cardiac output response to a fluid challenge in patients on controlled ventilation. Whether this applies to patients on pressure support ventilation is unknown. METHODS:Thirty consecutive patients wit...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-6576.2006.01120.x

    authors: Perner A,Faber T

    更新日期:2006-10-01 00:00:00

  • Haemodynamic responses to antagonism of pancuronium and alcuronium block.

    abstract::Using non-invasive methods, haemodynamic responses to antagonism of pancuronium (Pc) and alcuronium (Ac) block were compared in patients anaesthetized with thiopental-N2O-fentanyl and undergoing minor surgery. Neuromuscular block (90%) was maintained with Pc in 10 patients and Ac in 10 patients. After surgery, atropin...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1981.tb01594.x

    authors: Heinonen J,Salmenperä M,Takkunen O

    更新日期:1981-02-01 00:00:00

  • Cognitive function in patients with chronic pain treated with opioids: characteristics and associated factors.

    abstract:BACKGROUND:The paucity of studies regarding cognitive function in patients with chronic pain, and growing evidence regarding the cognitive effects of pain and opioids on cognitive function prompted us to assess cognition via neuropsychological measurement in patients with chronic non-cancer pain treated with opioids. ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2012.02760.x

    authors: Kurita GP,de Mattos Pimenta CA,Braga PE,Frich L,Jørgensen MM,Nielsen PR,Højsted J,Sjøgren P

    更新日期:2012-11-01 00:00:00

  • Complement partially mediates acid aspiration-induced remote organ injury in the rat.

    abstract:BACKGROUND:Acid aspiration into one lung is known to cause both a local as well as remote organ injury characterized by neutrophil sequestration and subsequent edema. This study investigated investigated the role of the complement cascade in the development of acid aspiration-induced local lung and remote organ injurie...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1997.tb04771.x

    authors: Yamada H,Kudoh I,Nishizawa H,Kaneko K,Miyazaki H,Ohara M,Okumura F

    更新日期:1997-06-01 00:00:00

  • Cell-mediated and humoral immune responses to total hip replacement under spinal or general anaesthesia.

    abstract::Regional anaesthesia has many advantages over general anaesthesia in hip surgery. When the effects of total hip replacement under spinal or general anaesthesia were compared in 22 patients, the only difference between the groups occurred in PHA-induced lymphocyte proliferative responses. In contrast, no differences be...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1990.tb03078.x

    authors: Salo M,Nissilä M

    更新日期:1990-04-01 00:00:00

  • Effects of dopamine in lung-transplanted pigs at 32 degrees C.

    abstract:BACKGROUND:We have used hypothermia successfully in patients with acute respiratory failure after lung transplantation. However, we have observed that dopamine may cause a substantial decrease in mean arterial pressure (MAP) in hypothermic subjects. Furthermore, a dopamine-induced increase in pulmonary vascular resista...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.1999.430705.x

    authors: Roscher R,Ingemansson R,Algotsson L,Sjöberg T,Steen S

    更新日期:1999-08-01 00:00:00

  • Effects of halothane, isoflurane, and sevoflurane on lipid peroxidation following experimental closed head trauma in rats.

    abstract:BACKGROUND:In a rat closed head trauma model we examined both the time course of lipid peroxidation and the effects of halothane, isoflurane, and sevoflurane on it by analysis of malondialdehyde (MDA) formation. METHODS:Animals were divided randomly into five groups: sham-operated (SO), n=18; control-closed head traum...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2008.01635.x

    authors: Yurdakoc A,Gunday I,Memiş D

    更新日期:2008-05-01 00:00:00

  • Postoperative epidural infusion of morphine and bupivacaine is safe on surgical wards. Organisation of the treatment, effects and side-effects in 2000 consecutive patients.

    abstract:BACKGROUND:There was an obvious need to improve the quality and safety of our postoperative pain treatment and to introduce an improved routine service on surgical wards. METHODS:It was decided to use postoperative epidural infusion of morphine 0.04 mg/ml and bupivacaine 2.5 mg/ml (0.25%) 4-8 ml/h as pain relief after...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1997.tb04802.x

    authors: Rygnestad T,Borchgrevink PC,Eide E

    更新日期:1997-08-01 00:00:00

  • Transcutaneous oxygen measurement in adult intensive care.

    abstract::Transcutaneous oxygen measurement (PtcO2-measurement) gives by a non-invasive technique continuous information about central PO2. The method has as yet been tested mainly on newborns, and systematic studies of the applicability of the method on adults are still few. The current systematic study reports on consecutive ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1979.tb01484.x

    authors: Löfgren O

    更新日期:1979-12-01 00:00:00

  • The interaction of temperature with thiopental and etomidate on extracellular dopamine and glutamate levels in Wistar-Kyoto rats subjected to forebrain ischemia.

    abstract:BACKGROUND:Many studies demonstrate an association between brain damage and the extracellular release of catecholamines and amino acids during cerebral ischemia. While the clinical value of hypothermia during periods of compromised cerebral blood flow and oxygen delivery is well established, the role of anesthetic agen...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.1999.431004.x

    authors: Lesser JB,Koorn R,Vloka JD,Kuroda MM,Thys DM

    更新日期:1999-11-01 00:00:00

  • Anesthesia for cesarean section V: effects of enflurane anesthesia on the respiratory adaptation of the newborn in elective cesarean section.

    abstract::The new anesthetic inhalation agent, enflurane, is supposed to allow rapid induction and recovery. Experinece with this agent in obstetrics is limited. Enflurane was therefore studied in 14 pregnant women undergoing elective cesarean section. Its effects upon the respiratory adaptation of the newborn infants were foll...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1976.tb05021.x

    authors: Magno R,Karlsson K,Selstam U,Wickström I

    更新日期:1976-01-01 00:00:00

  • Hepatopulmonary syndrome: a concern for the anesthetist? Pre-operative evaluation of hypoxemic patients with liver disease.

    abstract::Liver cirrhosis and other chronic hepatic diseases are followed in a subset of affected patients by gas exchange abnormalities resulting from a syndrome called hepatopulmonary syndrome (HPS). The structural basis of this clinical entity is an alteration of pulmonary vasculature resulting in abnormal vasodilatation and...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/j.0001-5172.2004.00282.x

    authors: Mazzeo AT,Lucanto T,Santamaria LB

    更新日期:2004-02-01 00:00:00

  • Pre-operative fasting guidelines: an update.

    abstract::Liberal pre-operative fasting routines have been implemented in most countries. In general, clear fluids are allowed up to 2 h before anaesthesia, and light meals up to 6 h. The same recommendations apply for children and pregnant women not in labour. In children <6 months, most recommendations now allow breast- or fo...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 指南,杂志文章,实务指引,评审

    doi:10.1111/j.1399-6576.2005.00781.x

    authors: Søreide E,Eriksson LI,Hirlekar G,Eriksson H,Henneberg SW,Sandin R,Raeder J,(Task Force on Scandinavian Pre-operative Fasting Guidelines, Clinical Practice Committee Scandinavian Society of Anaesthesiology and Intensive Care Medicine).

    更新日期:2005-09-01 00:00:00

  • The influence of naloxone infusion on the action of intrathecal diamorphine: low-dose naloxone and neuroendocrine responses.

    abstract::The influence of an intravenous infusion of naloxone 1 microgram kg-1 h-1, in combination with intrathecal diamorphine, on analgesia and hormonal stress responses after laminectomy was assessed in a blinded, randomized, placebo-controlled study. Twenty-seven patients undergoing laminectomy with postoperative analgesia...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1992.tb03455.x

    authors: Wright PM,O'Toole DP,Barron DW

    更新日期:1992-04-01 00:00:00

  • Pre-oxygenation enhances induction with sevoflurane as assessed using bispectral index monitoring.

    abstract:BACKGROUND:Several methods may enhance the inhalational induction of anesthesia. In this randomized double-blind study, we evaluated the speed of induction of anesthesia with sevoflurane with or without pre-oxygenation. METHODS:Fifty-four patients scheduled for hysteroscopy received for 10 min air or 100% oxygen via a...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2006.00981.x

    authors: Fassoulaki A,Petropoulos G,Kottis G,Sarantopoulos C

    更新日期:2006-04-01 00:00:00

  • Disturbing post-operative symptoms are not reduced by prophylactic antiemetic treatment in patients at high risk of post-operative nausea and vomiting.

    abstract:BACKGROUND:To give prophylactics or timely treatment for post-operative nausea and vomiting (PONV) is the question. We compared the intensity and number of disturbing post-operative symptoms (i.e. pain, PONV, headache, fatigue, etc.) after prophylactic antiemetic treatment in a group of patients with >30% risk for post...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.0001-5172.2004.00403.x

    authors: Alkaissi A,Gunnarsson H,Johnsson V,Evertsson K,Ofenbartl L,Kalman S

    更新日期:2004-07-01 00:00:00

  • Wound infiltration with local anesthetics for post-operative pain relief in lumbar spine surgery: a systematic review.

    abstract:BACKGROUND:In this systematic review, we evaluated double-blind, randomized and controlled trials on the effect of wound infiltration with local anesthetics compared with the effect of placebo on post-operative pain after lumbar spine surgery. METHODS:Medline, the Cochrane Library and Google Scholar were searched for ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/j.1399-6576.2011.02629.x

    authors: Kjærgaard M,Møiniche S,Olsen KS

    更新日期:2012-03-01 00:00:00

  • Psychological changes in children after anaesthesia: a comparison between halothane and ketamine.

    abstract::The psychological reactions to hospitalization, anaesthesia, and operation in a group of 107 children from 1 to 12 years old, anaesthetized with ketamine or halothane after randomization were investigated through questionnaires, which the parents answered 1 month postoperatively. The percentage of replies was 96.3%. F...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1977.tb01258.x

    authors: Modvig KM,Nielsen SF

    更新日期:1977-01-01 00:00:00

  • Ear injury caused by elevated intratympanic pressure during general anaesthesia.

    abstract::Two cases of middle-ear injury, due to sharp fluctuations of intratympanic pressure as a result of general anaesthesia with nitrous oxide are presented. A study is reported indicating that the degree of these fluctuations is a function of the concentration of nitrous oxide. In order to reduce the risk of middle-ear in...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1980.tb01539.x

    authors: Man A,Segal S,Ezra S

    更新日期:1980-06-01 00:00:00

  • Mucopolysaccharidoses and anaesthetic risks.

    abstract::The purpose of this review is to asses the current knowledge of mucopolysaccharidosis (MPS), with reference to the serious complications which may arise in connection with anaesthesia and operation. MPS consists of a heterogeneous group of hereditary diseases which are characterized by an abnormal accumulation of muco...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-6576.1987.tb02553.x

    authors: Sjøgren P,Pedersen T,Steinmetz H

    更新日期:1987-04-01 00:00:00

  • Does anaesthesia cause postoperative cognitive dysfunction? A randomised study of regional versus general anaesthesia in 438 elderly patients.

    abstract:BACKGROUND:Postoperative cognitive dysfunction (POCD) is a common complication after cardiac and major non-cardiac surgery with general anaesthesia in the elderly. We hypothesized that the incidence of POCD would be less with regional anaesthesia rather than general. METHODS:We included patients aged over 60 years und...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1034/j.1399-6576.2003.00057.x

    authors: Rasmussen LS,Johnson T,Kuipers HM,Kristensen D,Siersma VD,Vila P,Jolles J,Papaioannou A,Abildstrom H,Silverstein JH,Bonal JA,Raeder J,Nielsen IK,Korttila K,Munoz L,Dodds C,Hanning CD,Moller JT,ISPOCD2(International St

    更新日期:2003-03-01 00:00:00

  • A bolus dose of 1.5 mg/kg amrinone effectively improves low cardiac output state following separation from cardiopulmonary bypass in cardiac surgical patients.

    abstract:BACKGROUND:The aim of this study was to evaluate the efficacy of 1.5 mg/kg bolus of amrinone on low cardiac output (CO) state following emergence from cardiopulmonary bypass (CPB) in cardiac surgical patients. METHODS:Immediately after emergency from CPB, 14 patients with a cardiac index (CI) less than 2.2 l.min-1.m-2...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1998.tb05329.x

    authors: Kikura M,Levy JH,Bailey JM,Shanewise JS,Michelsen LG,Sadel SM

    更新日期:1998-08-01 00:00:00

  • Perceived cognitive impairments after critical illness: a longitudinal study in survivors and family member controls.

    abstract:BACKGROUND:Many former intensive care unit (ICU) patients report difficulties in cognitive functions especially in their daily life. We aimed to measure perceived cognitive impairments in daily life in survivors of critical illness and their family member controls (FMC). METHODS:Perceived cognitive impairments were as...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.12755

    authors: Baumbach P,Meissner W,Guenther A,Witte OW,Götz T

    更新日期:2016-09-01 00:00:00

  • Tissue distribution of thiopental and diazepam in rats at 71 atmospheres pressure.

    abstract::35S-thiopental 15 mg/kg and 14C-diazepam 5 mg/kg were injected intravenously in separate groups of rats (n = 6) at 1 ATA air and at 71 ATA air-He. Total radioactivity was measured in the brain, liver, kidney, muscle and fat after 1, 3, 5 and 15 min. The thiopental content was significantly reduced at pressure in the b...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1983.tb01982.x

    authors: Aanderud L,Thoner J,Bakke OM

    更新日期:1983-12-01 00:00:00

  • Use of the bispectral index to predict a positive awareness reaction to laryngeal mask airway-Fastrach insertion and intubation.

    abstract:AIM:To determine whether the bispectral index (BIS) can be monitored to predict and indicate an awareness reaction to laryngeal mask airway-Fastrach (LMA-Fastrach) insertion and intubation at BIS values between 40 and 60. METHODS:Fifty-one American Society of Anesthesiologists' (ASA) class I or II status patients aged...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2007.01441.x

    authors: Kocaman Akbay B,Demiraran Y,Yalcin Sezen G,Akcali G,Somunkiran A

    更新日期:2007-11-01 00:00:00