Controlled delivery of inductive proteins, plasmid DNA and cells from tissue engineering matrices.

abstract：BACKGROUND AND OBJECTIVE:This study aimed to assess the effectiveness of the treatment with alpha-terpineol (αTPN) complexed with beta-cyclodextrin (βCD) on oral, blood, and hepatic parameters in ligature-induced periodontitis. MATERIAL AND METHODS:Forty female rats were distributed among the following groups: control...

journal_title：Journal of periodontal research

authors： Vasconcelos ACCG,Vasconcelos DFP,da Silva FRP,França LFC,Alves EHP,Di Lenardo D,Pessoa LDS,Nascimento HMS,Carvalho ADS,Sousa FBM,Barbosa ALDR,Medeiros JR,Novaes PD,Mariano FS,Lima BDS,Araujo AAS,Júnior LJQ,de Oliveira A

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE AND BACKGROUND:To evaluate the association between periodontal disease, tooth loss and coronary heart disease (CHD). There is still controversy about the relationship between periodontal disease and tooth loss with vessel obstruction assessed using coronary angiography. MATERIAL AND METHODS:This cross-sectio...

journal_title：Journal of periodontal research

authors： Zanella SM,Pereira SS,Barbisan JN,Vieira L,Saba-Chujfi E,Haas AN,Rösing CK

更新日期：2016-04-01 00:00:00

abstract：:The influence of occlusal loading on periodontal fibroblasts was investigated in hypoloaded (shortened out of occlusion), functionally loaded and hyperloaded (constant linguointrusive mechanical loads of 9.4 +/- 0.06 g) lower left rat incisors. One hour following injection of 3H-thymidine, half of the animals in each ...

journal_title：Journal of periodontal research

authors： Michaeli Y,Shamir D,Weinreb M,Steigman S

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Neutrophil extracellular traps (NETs) are a recently discovered antimicrobial mechanism used by neutrophils that have been proposed as an intervention in the pathogenesis of periodontitis. The objective of our study was to characterize the expression of NETs in gingival tissues with periodontit...

journal_title：Journal of periodontal research

authors： Magán-Fernández A,O'Valle F,Abadía-Molina F,Muñoz R,Puga-Guil P,Mesa F

更新日期：2019-06-01 00:00:00

abstract：:Diploid fibroblasts obtained from explants of human gingiva and maintained in vitro undergo a several-fold decrease in protein and collagen synthesis as a function of increasing donor age. Using drug-induced gingival hyperplasia as a model, we performed experiments to learn whether fibroblasts derived from hyperplasti...

journal_title：Journal of periodontal research

authors： Johnson BD,Narayanan AS,Pieters HP,Page RC

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Enamel matrix derivative (EMD) is used clinically to promote periodontal tissue regeneration, and it has been reported that EMD can induce the formation of osteoclasts in mouse marrow cultures. In the present study, we investigated the mechanisms of EMD-induced osteoclast formation using a mous...

journal_title：Journal of periodontal research

authors： Itoh N,Kasai H,Ariyoshi W,Harada E,Yokota M,Nishihara T

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Fibronectin (FN) is an important cell adhesion molecule that is used widely to characterize cell behavior. Preparations of FN purified from human plasma by gelatin-Sepharose affinity chromatography typically also contain gelatin-binding gelatinases that may cleave FN, reduce its stability and a...

journal_title：Journal of periodontal research

authors： Pal S,Chen Z,Xu X,Mikhailova M,Steffensen B

更新日期：2010-04-01 00:00:00

abstract：:This study investigates a potential role for TGF beta 1 in the pathogenesis of cyclosporin A-induced gingival overgrowth (CsA-OG). TGF beta 1 was localized immunohistochemically in the connective tissue of both normal gingiva and CsA-OG. Intense staining for TGF beta 1 was detected at the tips of the dermal papillae o...

journal_title：Journal of periodontal research

authors： James JA,Irwin CR,Linden GJ

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Studies have shown that bacterial plaque and the associated gingival inflammation increase the severity of gingival overgrowth induced by cyclosporine-A (CsA). This in vitro study aimed to evaluate the effect of CsA on the activities of MMPs from the co-culture of human gingival fibroblasts and...

journal_title：Journal of periodontal research

authors： Kuo PJ,Tu HP,Chin YT,Lu SH,Chiang CY,Chen RY,Fu E

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Current epidemiological works have suggested that chronic infections, such as periodontitis, are associated with an increased risk of cardiovascular diseases, including hypertrophy and heart failure. However, mechanisms behind the association are not known. The aim of this study was to evaluate...

journal_title：Journal of periodontal research

authors： Köse O,Arabacı T,Gedikli S,Eminoglu DÖ,Kermen E,Kızıldağ A,Kara A,Ozkanlar S,Yemenoglu H

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:Endotoxin tolerance is characterized by a state of hyporesponsiveness after confrontation with endotoxins such as lipopolysaccharides (LPS) at low concentrations. The aim of this study was to investigate, whether pretreatment with Porphyromonas gingivalis leads to endotoxin tolerance induction and...

journal_title：Journal of periodontal research

authors： Blufstein A,Behm C,Nguyen PQ,Rausch-Fan X,Andrukhov O

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The purpose of this study was to determine any difference between Porphyromonas gingivalis isolates from periodontally healthy sites as compared to those from diseased sites with respect to the ability to invade host cells. MATERIAL AND METHODS:Subgingival plaque samples were obtained from per...

journal_title：Journal of periodontal research

authors： Jandik KA,Bélanger M,Low SL,Dorn BR,Yang MC,Progulske-Fox A

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Cyclosporine A treatment is important in the therapy of a number of medical conditions; however, alveolar bone loss is an important negative side-effect of this drug. As such, we evaluated whether concomitant administration of simvastatin would minimize cyclosporine A-associated alveolar bone l...

journal_title：Journal of periodontal research

authors： Nassar PO,Nassar CA,Guimarães MR,Aquino SG,Andia DC,Muscara MN,Spolidorio DM,Rossa C Jr,Spolidorio LC

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Smoking cigarettes increases the risk of oral tissue damage leading to periodontal disease. Gingival fibroblasts, the predominant cell type inhabiting gingival connective tissue, play a critical role in remodeling and maintaining gingival structure. The objective of this study was to investigat...

journal_title：Journal of periodontal research

authors： Alamri A,Semlali A,Jacques É,Alanazi M,Zakrzewski A,Chmielewski W,Rouabhia M

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The gingival epithelium is a first line of defense against bacterial challenge. E-cadherin (E-cad) plays an important role in cell-cell adhesion as a barrier in the epithelium. Recently, a decrease in the expression of E-cad has been observed in inflamed gingival tissue. The aims of this study ...

journal_title：Journal of periodontal research

authors： Abe-Yutori M,Chikazawa T,Shibasaki K,Murakami S

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Inducible nitric oxide synthase (iNOS) activity is known to regulate the immune response. The present study was carried out to determine the effect of L-N6-(1-iminoethyl)-lysine (L-NIL), an iNOS inhibitor, on the induction of immune response to Actinobacillus actinomycetemcomitans lipopolysacc...

journal_title：Journal of periodontal research

authors： Sosroseno W,Musa M,Ravichandran M,Fikri Ibrahim M,Bird PS,Seymour GJ

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Elevated nitric oxide (NO) has been associated with destructive periodontal disease. The aim of the present study was to test the hypothesis that exogenous NO may inhibit a protective immune response to Aggregatibacter actinomycetemcomitans lipopolysaccharide (LPS) in a murine model. MATERIAL ...

journal_title：Journal of periodontal research

authors： Sosroseno W,Bird PS,Seymour GJ

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:CYP1A1 rs1048943 polymorphism was reported to be correlated with periodontitis; however, its association with aggressive periodontitis (AgP) has not yet been investigated. The aim of the study was to investigate the association between the CYP1A1 gene rs1048943 variant with generalized aggressi...

journal_title：Journal of periodontal research

authors： Wang X,Li W,Song W,Xu L,Zhang L,Feng X,Lu R,Meng H

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Adipocyte fatty acid-binding protein (A-FABP) is expressed in adipocytes, macrophages and microvascular endothelial cells, and it plays a central role in inflammation, atherosclerosis and metabolic responses. This pilot study investigated the effect of nonsurgical periodontal therapy on the ser...

journal_title：Journal of periodontal research

authors： Li X,Tse HF,Yiu KH,Zhang C,Jin LJ

更新日期：2013-06-01 00:00:00

abstract：:The exact cell type and site(s) involved in interleukin-1 (IL-1) production during gingival inflammation was determined by combining immunohistochemistry and in situ hybridization. IL-1 messenger RNA (mRNA)-expressing cells in human inflamed gingiva were identified as macrophages. The rate of IL-alpha mRNA expression ...

journal_title：Journal of periodontal research

authors： Matsuki Y,Yamamoto T,Hara K

更新日期：1993-01-01 00:00:00

abstract：:The onset and progression of periodontal disease is associated with significant changes in the epithelial component of the attachment complex. From the early to the advanced stages of periodontal disease increased epithelial cell proliferation, migration and invasion into the surrounding connective tissue takes place....

journal_title：Journal of periodontal research

authors： Sanale AR,Firth JD,Uitto VJ,Putnins EE

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Interleukin-6 (IL-6) is a key proinflammatory cytokine that has been considered to be important in the pathogenesis of periodontal disease. Therefore, host-modulatory agents directed at inhibiting IL-6 appear to be beneficial in terms of attenuating periodontal disease progression and potential...

journal_title：Journal of periodontal research

authors： Jin JY,Choi EY,Park HR,Choi JI,Choi IS,Kim SJ

更新日期：2013-12-01 00:00:00

abstract：:Epidermal growth factor (EGF) is a small molecular weight polypeptide which is thought to have important functions in epithelial growth and differentiation and in wound healing. EGF exerts its action on cells through binding to a cell surface receptor. Using immunohistochemistry and a monoclonal antibody (mAb) directe...

journal_title：Journal of periodontal research

authors： Nordlund L,Hormia M,Saxén L,Thesleff I

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Lipopolysaccharide (LPS) on the cell wall of periodontal pathogens is a major mediator of the inflammatory response and can enhance alveolar bone resorption in periodontitis. Bone sialoprotein is an early marker of osteoblast differentiation. The proinflammatory cytokine, interleukin-8 (IL-8), ...

journal_title：Journal of periodontal research

authors： Zhang Y,Li X

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:It is recognized that orthodontic force (OF) has an aggravating effect on the progression of destructive periodontitis if periodontitis have not been well controlled. However, the underlying mechanism is not completely clear. This study was to investigate the effect of antibiotic administratio...

journal_title：Journal of periodontal research

authors： Shi J,Liu Z,Kawai T,Zhou Y,Han X

更新日期：2017-08-01 00:00:00

abstract：:The effectiveness of an ideal antimicrobial agent depends on its ability to kill microbes with minimal toxicity to host cells. Depending on the treatment regimen, antimicrobial agents come into contact with host cells for various intervals of time. Sanguinarium (SANG), chlorhexidine (CHX) and tetracycline (TET) are 3 ...

journal_title：Journal of periodontal research

authors： Agarwal S,Piesco NP,Peterson DE,Charon J,Suzuki JB,Godowski KC,Southard GL

更新日期：1997-04-01 00:00:00

abstract：:Some bacterial antigens such as S. aureus enterotoxins can selectively stimulate T cells that express specific V beta genes of the T cell antigen receptor (TCR). The purpose of this study was to investigate whether or not periodontal bacteria could similarly alter the expression of V beta families within the TCR compl...

journal_title：Journal of periodontal research

authors： Mathur A,Michalowicz B,Yang C,Aeppli D

更新日期：1995-09-01 00:00:00

abstract：:The goal of a single step therapy has been an important consideration in the development of guided tissue regeneration devices. It would spare the patient from the need for repeated surgery and eliminate many problems associated with a non-resorbable barrier. Animal studies of a collagen membrane extracted from porcin...

journal_title：Journal of periodontal research

authors： Lu HK,Lee SY,Lin FP

更新日期：1998-07-01 00:00:00

abstract：:The immunoglobulin class distribution of antibody to human collagen type I has been examined in sera and gingival extracts from patients with adult chronic periodontitis. Tissue extracts were made either by simple washing or ultrasonication. With either method, IgG and IgA antibodies to collagen were present in higher...

journal_title：Journal of periodontal research

authors： Anusaksathien O,Singh G,Matthews N,Dolby AE

更新日期：1992-01-01 00:00:00

abstract：:We investigated the co-localization of lysosomal cathepsins B, H and L, and horseradish peroxidase (HRP) in junctional epithelial (JE) cells both as a fluid-phase endocytotic marker to demonstrate the fluid-phase endocytotic capacity of JE cells, and to understand the morphological relationships of the endocytosed for...

journal_title：Journal of periodontal research

authors： Yamaza T,Kido MA,Kiyoshima T,Nishimura Y,Himeno M,Tanaka T

更新日期：1997-11-01 00:00:00