Differential regulation of TSG-14 expression in murine fibroblasts and peritoneal macrophages.

abstract：:Radiation-induced chimeric mice were used to study the origin of pulmonary alveolar macrophages. Unlike in other studies, these radiation chimeras were prepared by using a special fractionated irradiation regimen to minimize the killing of alveolar macrophage colony-forming cells, putative local stem cells. For this s...

journal_title：Journal of leukocyte biology

authors： Tarling JD,Lin HS,Hsu S

更新日期：1987-11-01 00:00:00

abstract：:Pulmonary sequestration and activation of polymorphonuclear leukocytes (PMNLs) are characteristic of many forms of acute lung injury. The present experiments were designed to study the effects of mepacrine on human neutrophils challenged with N-formylmethionyl-leucyl-phenylalanine (fMLP). Mepacrine inhibited fMLP-indu...

journal_title：Journal of leukocyte biology

authors： Földes-Filep E,Filep JG

更新日期：1992-11-01 00:00:00

abstract：:In this study we present data on a novel cell surface antigen recognized by monoclonal antibody (mAb) VPM30, originally thought to recognize only bovine and ovine sIg+ B cells from peripheral blood. Here we show that the antigen, molecular mass 28 kDa, is not only found in B cell follicles in frozen sections, but when...

journal_title：Journal of leukocyte biology

authors： Campbell JD,Hopkins J,Howie SE,Oliver RA,Nichani AK,Goel P,Spooner RL,Glass EJ

更新日期：1998-05-01 00:00:00

abstract：:Multiple mechanisms are used by the human immunodeficiency virus type 1 (HIV-1) to interfere with host-cell immune effector functions. The 27-kD Nef protein has been shown to down-modulate specific genes of the major histocompatibility complex class I (MHC-I) on the surface of infected primary T cells, facilitating th...

journal_title：Journal of leukocyte biology

authors： Brown A,Gartner S,Kawano T,Benoit N,Cheng-Mayer C

更新日期：2005-09-01 00:00:00

abstract：:Intracellular pathogens, including Mycobacterium tuberculosis, obtain iron from the host for their survival. Ferroportin 1 (FPN1; SLC40A1) is the sole iron exporter from mammalian cells and is expressed in the duodenum and macrophages. In the present study, we show that FPN1 mRNA levels in the mouse macrophage cell li...

journal_title：Journal of leukocyte biology

authors： Van Zandt KE,Sow FB,Florence WC,Zwilling BS,Satoskar AR,Schlesinger LS,Lafuse WP

更新日期：2008-09-01 00:00:00

abstract：:The role of Myeloid-Derived Suppressor Cells (MDSC) in infant immune ontogeny is unknown. Here, we evaluated MDSC frequency and relationship with infant vaccine responses throughout the first year of life in a prospective cohort study. Ninety-one South African infant-mother pairs were enrolled at delivery, and blood s...

journal_title：Journal of leukocyte biology

authors： Kidzeru E,Gasper MA,Shao D,Edlefsen PT,Lejarcegui N,Havyarimana E,Urdahl K,Gantt S,Horton H,Jaspan H,Gervassi A

更新日期：2021-01-21 00:00:00

abstract：:THP-1-derived cell lines were stably transfected with constructs encoding glycophosphatidylinositol (GPI)-anchored or transmembrane forms of human CD14. CD14 expression was associated with enhanced phagocytosis of serum (heat-inactivated)-opsonized Escherichia coli (opEc). Both the GPI-anchored and transmembrane forms...

journal_title：Journal of leukocyte biology

authors： Schiff DE,Kline L,Soldau K,Lee JD,Pugin J,Tobias PS,Ulevitch RJ

更新日期：1997-12-01 00:00:00

abstract：:A wealth of scientific and clinical evidence during the past few years has lent credence to the idea that key components of the host immune effector mechanisms can be targeted to boost current tuberculosis (TB) treatment and control patient relapse. These host-directed strategies not only accelerate the clearance of p...

journal_title：Journal of leukocyte biology

authors： Cheng CY,Böhme J,Singhal A

更新日期：2018-02-01 00:00:00

abstract：:Attempts to analyze bone marrow-derived macrophages (BMDM) by flow cytometry have been prohibited because of their high autofluorescence. Using an autofluorescence reduction method of Steinkamp and Stewart to reduce the autofluorescence of BMDM, we were able to examine several macrophage populations for their expressi...

journal_title：Journal of leukocyte biology

authors： Malley A,Stewart CC,Stewart SJ,Waldbeser L,Bradley LM,Shiigi SM

更新日期：1988-06-01 00:00:00

abstract：:Angiogenesis is essential in many physiological and pathological processes and can be stimulated by many different factors. To better understand and to manipulate this process more effectively, it would be beneficial to identify molecules common to the signaling pathways stimulated by different classes of angiogenic f...

journal_title：Journal of leukocyte biology

authors： Yao M,Zhou RH,Petreaca M,Zheng L,Shyy J,Martins-Green M

更新日期：2006-09-01 00:00:00

abstract：:Vitamin B9, commonly known as folate, is an essential cofactor for one-carbon metabolism that enters cells through three major specialized transporter molecules (RFC, FR, and PCFT), which differ in expression pattern, affinity for substrate, and ligand-binding pH dependency. We now report that the expression of the fo...

journal_title：Journal of leukocyte biology

authors： Samaniego R,Palacios BS,Domiguez-Soto Á,Vidal C,Salas A,Matsuyama T,Sánchez-Torres C,de la Torre I,Miranda-Carús ME,Sánchez-Mateos P,Puig-Kröger A

更新日期：2014-05-01 00:00:00

abstract：:Notch signaling plays a preeminent role during development in not only regulating cell fate decisions, but it can also influence growth and survival of progenitor cells. In the immune system, Notch is required for the maintenance of hematopoietic stem cells and in directing T- versus B-lineage commitment. In this revi...

journal_title：Journal of leukocyte biology

authors： Hoyne GF

更新日期：2003-12-01 00:00:00

abstract：:IL-1 receptor-associated kinase (IRAK) 4 is a central enzyme of the TLR pathways. This study tested the hypothesis that IRAK4 kinase activity is prerequisite for regulating innate immunity during infections with intracellular bacteria. To this end, we analyzed responses of macrophages obtained from mice expressing wil...

journal_title：Journal of leukocyte biology

authors： Pattabiraman G,Murphy M,Agliano F,Karlinsey K,Medvedev AE

更新日期：2018-10-01 00:00:00

abstract：:Macrophages and dendritic cells are in the front line of host defense. When they sense host invasion, they produce cytokines that alert other innate immune cells and also abet the development of an adaptive immune response. Although lipolysaccharide (LPS), peptidoglycan, unmethylated DNA, and other microbial products ...

journal_title：Journal of leukocyte biology

authors： Beutler B,Hoebe K,Du X,Ulevitch RJ

更新日期：2003-10-01 00:00:00

abstract：:A sensitive in vitro assay for generation of human leukocytic pyrogen has been used to study the pathogenesis of fever accompanying administration of human alpha-interferon. Unlike other potent pyrogens, two recombinant interferon preparations tested over a wide concentration range did not stimulate release of leukocy...

journal_title：Journal of leukocyte biology

authors： Ackerman SK,Hochstein HD,Zoon K,Browne W,Rivera E,Elisberg B

更新日期：1984-07-01 00:00:00

abstract：:Complement component C1q is a member of a family of soluble proteins called defense collagens, which are important in host defense and apoptotic cell clearance. Failure to efficiently clear apoptotic cells in the absence of C1q is associated with autoimmunity. Here, we review the literature describing a central role f...

journal_title：Journal of leukocyte biology

authors： Galvan MD,Greenlee-Wacker MC,Bohlson SS

更新日期：2012-09-01 00:00:00

abstract：:Bovine plasma contains factors that can stimulate bovine neutrophils. Bovine plasma at 1:1,000,000-1:1,000 dilution induced a dose-dependent superoxide production in bovine neutrophils. When bovine plasma was fractionated with a protein G column, only the IgG fraction contained induction activity. At similar concentra...

journal_title：Journal of leukocyte biology

authors： Tao W,Corbett MJ,Pickett W

更新日期：1995-08-01 00:00:00

abstract：:In this study, we have investigated the expression of phospholipase C-beta2 during the course of granulocytic differentiation of normal and malignant progenitors. As a model system, we used the NB4 cell line, a reliable in vitro model for the study of acute promyelocytic leukemia (APL), a variety of acute myeloid leuk...

journal_title：Journal of leukocyte biology

authors： Bertagnolo V,Marchisio M,Pierpaoli S,Colamussi ML,Brugnoli F,Visani G,Zauli G,Capitani S

更新日期：2002-06-01 00:00:00

abstract：:The objective of this study was to find the role of LncRNA SNHG12 in the regulation of hypertensive vascular endothelial injury. LncRNA SNHG12 and miR-25-3p expression were detected by quantitative RT-PCR. Protein levels of Sirtuin 6 (SIRT6), endothelial cell (EC) senescence markers p16 and p21, and EC marker CD31 wer...

journal_title：Journal of leukocyte biology

authors： Qian W,Zheng ZQ,Nie JG,Liu LJ,Meng XZ,Sun H,Xiao FM,Kang T

更新日期：2021-01-19 00:00:00

abstract：:Underlying acquired immunity to the fungus Candida albicans is usually present in adult immunocompetent individuals and is presumed to prevent mucosal colonization progressing to symptomatic infection. Exploration of immunological events leading to Candida resistance or susceptibility has indicated the central role of...

journal_title：Journal of leukocyte biology

authors： Romani L

更新日期：2000-08-01 00:00:00

abstract：:A murine model of allergic bronchopulmonary aspergillosis (ABPA), developed by exposure to Aspergillus fumigatus antigens, demonstrated eosinophilia of peripheral blood (PB), bone marrow (BM), and lung. The eosinophilia was abrogated by monoclonal anti-interleukin-5 (IL-5) antibody (TRFK-5) and not by an isotype contr...

journal_title：Journal of leukocyte biology

authors： Murali PS,Kumar A,Choi H,Banasal NK,Fink JN,Kurup VP

更新日期：1993-03-01 00:00:00

abstract：:Zinc is an essential element important for growth, the nervous system, and especially the immune system. Zinc deficiency as well as levels well above normal, due to high-dose treatment, showed an impaired immune function. This review summarizes the current status of zinc's significance for leukocyte biology and health...

journal_title：Journal of leukocyte biology

authors： Wellinghausen N,Rink L

更新日期：1998-11-01 00:00:00

abstract：:Autism spectrum disorders (ASD) are part of a broad spectrum of neurodevelopmental disorders known as pervasive developmental disorders, which occur in childhood. They are characterized by impairments in social interaction, verbal and nonverbal communication and the presence of restricted and repetitive stereotyped be...

journal_title：Journal of leukocyte biology

authors： Ashwood P,Wills S,Van de Water J

更新日期：2006-07-01 00:00:00

abstract：:Mast cells and MDSCs are increased by parasitic infection and tumor growth. We previously demonstrated that enhanced MDSC development in ADAM10 transgenic mice yielded resistance to Nb infection and that coculturing MDSCs and mast cells enhanced cytokine production. In the current work, we show that MDSC-mast cell coc...

journal_title：Journal of leukocyte biology

authors： Morales JK,Saleem SJ,Martin RK,Saunders BL,Barnstein BO,Faber TW,Pullen NA,Kolawole EM,Brooks KB,Norton SK,Sturgill J,Graham L,Bear HD,Urban JF Jr,Lantz CS,Conrad DH,Ryan JJ

更新日期：2014-04-01 00:00:00

abstract：:The colony-stimulating factors (CSF) belong to a group of proteins which regulate blood cell production. Human monocytes allowed to adhere express high levels of M-CSF transcripts and secreted protein at 24 h in the presence but not in the absence of indomethacin (Indo), an inhibitor of prostaglandin E (PGE) productio...

journal_title：Journal of leukocyte biology

authors： Lee MT,Kaushansky K,Ralph P,Ladner MB

更新日期：1990-03-01 00:00:00

abstract：:During highly active antiretroviral therapy (HAART), HIV-1 can still persist in circulating, resting CD4+ T lymphocytes, lymph node mononuclear cells, and seminal cells of patients despite sustained suppression of plasma viremia to undetectable levels. Sanctuary sites where antiretroviral drug penetration is not optim...

journal_title：Journal of leukocyte biology

authors： Crowe SM,Sonza S

更新日期：2000-09-01 00:00:00

abstract：:Chemotactic factors and phorbol esters may act synergistically to evoke neutrophil responses, but the mechanism of such interaction is not entirely clear. We investigated the combined effects of the chemotactic peptide n-formyl-methionyl-leucyl-phenylalanine (FMLP) and phorbol myristate acetate (PMA) on protein kinase...

journal_title：Journal of leukocyte biology

authors： Gay JC,Stitt ES

更新日期：1990-01-01 00:00:00

abstract：:T cell Ig and mucin domain-containing molecule 3 (Tim-3) has been found to play important roles in autoimmune diseases, but whether Tim-3-mediated engulfment of apoptotic cells is involved in systemic lupus erythematosus (SLE) remains to be elucidated. In this study, we verified the role of human Tim-3 (hTim-3) as the...

journal_title：Journal of leukocyte biology

authors： Zhao D,Guo M,Liu B,Lin Q,Xie T,Zhang Q,Jia X,Shu Q,Liang X,Gao L,Ma C

更新日期：2017-12-01 00:00:00

abstract：:M-CSF and GM-CSF are mediators involved in regulating the numbers and function of macrophage lineage populations and have been shown to contribute to macrophage heterogeneity. Type I IFN is an important mediator produced by macrophages and can have profound regulatory effects on their properties. In this study, we com...

journal_title：Journal of leukocyte biology

authors： Fleetwood AJ,Dinh H,Cook AD,Hertzog PJ,Hamilton JA

更新日期：2009-08-01 00:00:00

abstract：:Signaling through chemokine receptor, C-X-C chemokine receptor type 4 (CXCR4) regulates essential processes in normal physiology, including embryogenesis, tissue repair, angiogenesis, and trafficking of immune cells. Tumors co-opt many of these fundamental processes to directly stimulate proliferation, invasion, and m...

journal_title：Journal of leukocyte biology

authors： Luker GD,Yang J,Richmond A,Scala S,Festuccia C,Schottelius M,Wester HJ,Zimmermann J

更新日期：2020-10-26 00:00:00