Murine gammaherpesvirus 68 cyclin D homologue is required for efficient reactivation from latency.

abstract：:Reverse transcriptases (RTs) are found in a wide variety of mobile genetic elements including viruses, retrotransposons, and infectious organellar introns. An invariant triad of aspartates is thought to be required for the catalytic function of RTs. We generated RT mutants in the yeast retrotransposon Ty1, changing ea...

journal_title：Journal of virology

authors： Uzun O,Gabriel A

更新日期：2001-07-01 00:00:00

abstract：:Recombinant human cytomegaloviruses that do not express UL97 kinase activity exhibit a distinctive plaque morphology characterized by the formation of highly refractile bodies late in infection. These structures were also observed in infected cells treated with the UL97 kinase inhibitor maribavir. Nuclear inclusions w...

journal_title：Journal of virology

authors： Prichard MN,Britt WJ,Daily SL,Hartline CB,Kern ER

更新日期：2005-12-01 00:00:00

abstract：:A number of cDNA clones complementary to measles virus mRNA and 50S genome RNA have been generated. These clones have been mapped by restriction enzyme analysis and were subsequently sequenced by the method of Maxam and Gilbert (A. M. Maxam and W. Gilbert, Methods Enzymol. 65:499-560, 1980). Computer analysis of these...

journal_title：Journal of virology

authors： Richardson CD,Berkovich A,Rozenblatt S,Bellini WJ

更新日期：1985-04-01 00:00:00

abstract：:FeLV-FAIDS, an immunodeficiency-inducing isolate of feline leukemia virus, is composed of a pathogenic but replication-defective genome (molecular clone 61C) and a replication-competent but non-immunodeficiency-inducing variant genome (molecular clone 61E). The chimeric virus EECC, composed of the 5' gag-pol of 61E fu...

journal_title：Journal of virology

authors： Poss ML,Quackenbush SL,Mullins JI,Hoover EA

更新日期：1990-09-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) remains latent throughout the life of the carrier, with cells containing the provirus and viral gene expression efficiently down-regulated. On a molecular level, exactly how viruses are down-regulated in vivo remains unresolved. We described here the possibility that down-re...

journal_title：Journal of virology

authors： Saiga A,Orita S,Minoura-Tada N,Maeda M,Aono Y,Asakawa M,Nakahara K,Kubota R,Osame M,Igarashi H

更新日期：1997-06-01 00:00:00

abstract：:The infectious entry pathway of duck hepatitis B virus (DHBV) was investigated with primary duck hepatocytes. Virus uptake was measured by a selective PCR technique which allows for the detection of a successful infection without the need for viral replication or gene expression. To test whether DHBV uptake occurs by ...

journal_title：Journal of virology

authors： Köck J,Borst EM,Schlicht HJ

更新日期：1996-09-01 00:00:00

abstract：:The virus-encoded proteins of tobacco etch virus (TEV), a plant potyvirus, arise by proteolytic processing of a large polyprotein precursor. The TEV genome codes for two proteinases, a 49-kilodalton proteinase and helper component proteinase (HC-Pro), which cleave the polyprotein at specific sites. The only known clea...

journal_title：Journal of virology

authors： Carrington JC,Freed DD,Sanders TC

更新日期：1989-10-01 00:00:00

abstract：:The glycan shield comprised of multiple carbohydrate chains on the human immunodeficiency virus (HIV) envelope glycoprotein gp120 helps the virus to evade neutralizing antibodies. The present study describes a novel method for increasing immunogenicity of gp120 vaccine by enzymatic replacement of sialic acid on these ...

journal_title：Journal of virology

authors： Abdel-Motal U,Wang S,Lu S,Wigglesworth K,Galili U

更新日期：2006-07-01 00:00:00

abstract：:The vpr sequences from six human immunodeficiency virus type 1 (HIV-1)-infected mother-infant pairs following perinatal transmission were analyzed. We found that 153 of the 166 clones analyzed from uncultured peripheral blood mononuclear cell DNA samples showed a 92.17% frequency of intact vpr open reading frames. The...

journal_title：Journal of virology

authors： Yedavalli VR,Chappey C,Ahmad N

更新日期：1998-08-01 00:00:00

abstract：:The steady-state level and metabolic half-life of retinoblastoma tumor suppressor protein pRB are decreased in cells that express high-risk human papillomavirus (HPV) E7 proteins. Here we show that pRB degradation is a direct activity of E7 and does not reflect a property of cell lines acquired during the selection pr...

journal_title：Journal of virology

authors： Gonzalez SL,Stremlau M,He X,Basile JR,Münger K

更新日期：2001-08-01 00:00:00

abstract：:The Graffi murine leukemia virus (MuLV) is a retroviral mixture that induces predominantly myeloid leukemia in several inbred strains of mice. To analyze the viral component responsible for the myeloid leukemogenesis, we cloned several proviruses from a Graffi MuLV-infected cell line. Several infectious molecular clon...

journal_title：Journal of virology

authors： Ru M,Shustik C,Rassart E

更新日期：1993-08-01 00:00:00

abstract：:The major histocompatibility complex (MHC) class I region of humans, chimpanzees (Pan troglodytes), and bonobos (Pan paniscus) is highly similar, and orthologues of HLA-A, -B, and -C are present in both Pan species. Based on functional characteristics, the different HLA-A allotypes are classified into different supert...

journal_title：Journal of virology

authors： de Groot NG,Heijmans CMC,de Ru AH,Otting N,Koning F,van Veelen PA,Bontrop RE

更新日期：2020-04-16 00:00:00

abstract：:Helicobacter pylori causes peptic ulcers and gastric cancer, which lead to significantly higher morbidity in Japan than elsewhere in the world. As bacteriophage (phage) and host bacteria coevolve, the study of H. pylori phages is important to extend understanding of the evolution and pathogenesis of H. pylori. Here we...

journal_title：Journal of virology

authors： Uchiyama J,Takeuchi H,Kato S,Takemura-Uchiyama I,Ujihara T,Daibata M,Matsuzaki S

更新日期：2012-10-01 00:00:00

abstract：:Prior studies have demonstrated that a small proportion of blood lymphocytes from patients with human cytomegalovirus (HCMV) infection express only the viral immediate-early (IE) genes (L. Einhorn and A. Ost, J. Infect. Dis. 149:207-214, 1984; G. P. A. Rice, R. D. Schrier, and M. B. A. Oldstone, Proc. Natl. Acad. Sci....

journal_title：Journal of virology

authors： Hunninghake GW,Monick MM,Liu B,Stinski MF

更新日期：1989-07-01 00:00:00

abstract：:Transmission of human immunodeficiency virus type 1 (HIV-1) occurs primarily via the mucosal route, suggesting that HIV-1 vaccines may need to elicit mucosal immune responses. Here, we investigated the immunogenicity and relative efficacy of systemic immunization with two human ALVAC-HIV-1 recombinant vaccines express...

journal_title：Journal of virology

authors： Pal R,Venzon D,Santra S,Kalyanaraman VS,Montefiori DC,Hocker L,Hudacik L,Rose N,Nacsa J,Edghill-Smith Y,Moniuszko M,Hel Z,Belyakov IM,Berzofsky JA,Parks RW,Markham PD,Letvin NL,Tartaglia J,Franchini G

更新日期：2006-04-01 00:00:00

abstract：:Semlike forest virus capsid protein cosedimented with the large ribosomal subunit at 60S in sucrose gradients after treatment of cytoplasm from infected cells with Triton X-100 and EDTA. In CsCl gradients the capsid protein banded with the subunit at a density of 1.56 to 1.57 g/cm3. Most of the capsid protein could be...

journal_title：Journal of virology

authors： Ulmanen I,Söderlund H,Kääriäinen L

更新日期：1976-10-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) recognize virus peptide fragments complexed with class I major histocompatibility complex (MHC) molecules on the surface of virus-infected cells. Recognition is mediated by a membrane-bound T-cell receptor (TCR) composed of alpha and beta chains. Studies of the CTL response to lymphocytic...

journal_title：Journal of virology

authors： Yanagi Y,Tishon A,Lewicki H,Cubitt BA,Oldstone MB

更新日期：1992-04-01 00:00:00

abstract：:Human papillomavirus type 16 (HPV16) is the primary etiologic agent for cervical cancer. The infectious entry of HPV16 into cells occurs via a so-far poorly characterized clathrin- and caveolin-independent endocytic pathway, which involves tetraspanin proteins and actin. In this study, we investigated the specific rol...

journal_title：Journal of virology

authors： Scheffer KD,Gawlitza A,Spoden GA,Zhang XA,Lambert C,Berditchevski F,Florin L

更新日期：2013-03-01 00:00:00

abstract：:We are using site-directed mutagenesis of single viral genes to identify and analyze the genetic determinants of human and simian immunodeficiency virus pathogenicity. In a first approach, we have constructed a series of simian immunodeficiency virus SIVmac nef mutants by partial deletion and insertions in the nef gen...

journal_title：Journal of virology

authors： Binninger D,Ennen J,Bonn D,Norley SG,Kurth R

更新日期：1991-10-01 00:00:00

abstract：:Transgene expression after the administration of recombinant adenovirus with E1 deleted is constantly transient. It is admitted that E1A-substituting activities of cellular or viral origin allow viral antigen synthesis and trigger cytotoxic lymphocyte-mediated clearance of the recipient cells. Our approach to solving ...

journal_title：Journal of virology

authors： Yeh P,Dedieu JF,Orsini C,Vigne E,Denefle P,Perricaudet M

更新日期：1996-01-01 00:00:00

abstract：:Initiation of the Epstein-Barr virus (EBV) lytic cycle is dependent on expression of the viral transactivator Zta, which is encoded by the BZLF1 gene. Described here is an initial mapping of the regions of Zta involved in activating transcription. The data indicate that the amino-terminal 153 amino acids of Zta are im...

journal_title：Journal of virology

authors： Flemington EK,Borras AM,Lytle JP,Speck SH

更新日期：1992-02-01 00:00:00

abstract：:The viral dynamics in human immunodeficiency virus type 1 (HIV-1) infection have been studied extensively using mathematical modeling, but data from other primate lentivirus systems are scarce. This study was initiated to increase the understanding of the differences and similarities between the different primate lent...

journal_title：Journal of virology

authors： Brandin E,Thorstensson R,Bonhoeffer S,Albert J

更新日期：2006-10-01 00:00:00

abstract：:The initiation of human immunodeficiency virus type 1 (HIV-1) reverse transcription occurs at a site in the viral RNA genome which is designated the primer-binding site (PBS). The HIV-1 PBS is an 18-nucleotide sequence that is complementary to the 3'-terminal 18 nucleotides of tRNA(3Lys), which is used as the primer f...

journal_title：Journal of virology

authors： Wakefield JK,Wolf AG,Morrow CD

更新日期：1995-10-01 00:00:00

abstract：:The movement protein (MP) of Tobacco mosaic virus mediates the cell-to-cell transport of viral RNA through plasmodesmata, cytoplasmic cell wall channels for direct cell-to-cell communication between adjacent cells. Previous in vivo studies demonstrated that the RNA transport function of the protein correlates with its...

journal_title：Journal of virology

authors： Ferralli J,Ashby J,Fasler M,Boyko V,Heinlein M

更新日期：2006-06-01 00:00:00

abstract：UNLABELLED:Herpes simplex virus 1 (HSV-1) glycoprotein B (gB)-specific CD8(+) T cells protect mice from herpes infection and disease. However, whether and which HSV-1 gB-specific CD8(+) T cells play a key role in the "natural" protection seen in HSV-1-seropositive healthy asymptomatic (ASYMP) individuals (who have neve...

journal_title：Journal of virology

authors： Khan AA,Srivastava R,Spencer D,Garg S,Fremgen D,Vahed H,Lopes PP,Pham TT,Hewett C,Kuang J,Ong N,Huang L,Scarfone VM,Nesburn AB,Wechsler SL,BenMohamed L

更新日期：2015-04-01 00:00:00

abstract：:Polyamides have been shown to bind double-stranded DNA by complementing the curvature of the minor groove and forming various hydrogen bonds with DNA. Several polyamide molecules have been found to have potent antiviral activities against papillomavirus, a double-stranded DNA virus. By analogy, we reason that polyamid...

journal_title：Journal of virology

authors： Gumpper RH,Li W,Castañeda CH,Scuderi MJ,Bashkin JK,Luo M

更新日期：2018-03-28 00:00:00

abstract：UNLABELLED:Herpes simplex virus 1 (HSV-1) and HSV-2 are among the most prevalent human pathogens. Both viruses can recognize, via the surface envelope glycoprotein D (gD), human nectin-1 as a functional receptor. Previous studies have successfully elucidated the molecular basis of the binding between HSV-1 gD and necti...

journal_title：Journal of virology

authors： Lu G,Zhang N,Qi J,Li Y,Chen Z,Zheng C,Gao GF,Yan J

更新日期：2014-12-01 00:00:00

abstract：:Members of the Flaviviridae encode a serine proteinase termed NS3 that is responsible for processing at several sites in the viral polyproteins. In this report, we show that the NS3 proteinase of the pestivirus bovine viral diarrhea virus (BVDV) (NADL strain) is required for processing at nonstructural (NS) protein si...

journal_title：Journal of virology

authors： Xu J,Mendez E,Caron PR,Lin C,Murcko MA,Collett MS,Rice CM

更新日期：1997-07-01 00:00:00

abstract：:Cowpox virus, in contrast to vaccinia virus, can multiply in Chinese hamster ovary cells. To study the genetic basis for this difference in host range, recombinants between vaccinia and cowpox viruses were isolated and their DNA restriction patterns were examined. The ability to multiply in Chinese hamster ovary cells...

journal_title：Journal of virology

authors： Spehner D,Gillard S,Drillien R,Kirn A

更新日期：1988-04-01 00:00:00

abstract：:Epstein-Barr virus (EBV) uses tonsils as the portal of entry to establish persistent infection. EBV is found in various B-cell subsets in tonsils but exclusively in memory B cells in peripheral blood. The in vitro susceptibilities of B-cell subsets to EBV infection have been studied solely qualitatively. In this work,...

journal_title：Journal of virology

authors： Dorner M,Zucol F,Berger C,Byland R,Melroe GT,Bernasconi M,Speck RF,Nadal D

更新日期：2008-05-01 00:00:00