The Epstein-Barr virus promoter initiating B-cell transformation is activated by RFX proteins and the B-cell-specific activator protein BSAP/Pax5.

abstract：:Certain chicken cells that do not spontaneously release virus particles have been shown to produce a subgroup E avian RNA tumor virus, Rous-associated virus 60 (RAV-60), after infection with viruses of other subgroups. The nucleic acids of RAV-60 were analyzed for sequence homologies with the viral nucleic acids conta...

journal_title：Journal of virology

authors： Hayward WS,Hanafusa H

更新日期：1975-06-01 00:00:00

abstract：:Herpesviruses establish latency in suitable host cells after primary infection and persist in their host organisms for life. Most of the viral genes are silenced during latency, also enabling the virus to escape from an immune response. This study addresses the control of viral gene silencing by epigenetic mechanisms,...

journal_title：Journal of virology

authors： Alberter B,Vogel B,Lengenfelder D,Full F,Ensser A

更新日期：2011-06-01 00:00:00

abstract：:Recently developed antiviral strategies based upon RNA interference (RNAi), which harnesses an innate cellular system for the targeted down-regulation of gene expression, appear highly promising and offer alternative approaches to conventional highly active antiretroviral therapy or efforts to develop an AIDS vaccine....

journal_title：Journal of virology

authors： Leonard JN,Schaffer DV

更新日期：2005-02-01 00:00:00

abstract：:Simian virus 40 mutants lacking sequences in the late leader region are viable but produce smaller plaques than does wild-type virus. Within three passages at low multiplicities of infection, virus stocks of several such mutants accumulated variants that synthesized an altered form of the major virion protein, VP1, ha...

journal_title：Journal of virology

authors： Barkan A,Welch RC,Mertz JE

更新日期：1987-10-01 00:00:00

abstract：:The human genome encodes over 500 microRNAs (miRNAs), small RNAs (19 to 26 nucleotides [nt]) that regulate the expressions of diverse cellular genes. Many cellular processes are altered through a variety of mechanisms by human cytomegalovirus (HCMV) infection. We asked whether HCMV infection leads to changes in the ex...

journal_title：Journal of virology

authors： Wang FZ,Weber F,Croce C,Liu CG,Liao X,Pellett PE

更新日期：2008-09-01 00:00:00

abstract：:Co-infection of neonatal BALB/c mice with Friend virus (FV) complex (containing defective spleen focus-forming virus [SFFV] and endogenous N-tropic leukemia-inducing helper virus [LLV-F]) and B-tropic Tennant leukemia virus (TenLV) resulted in the inhibition of LLV-F by the Fv-1(b) gene and recovery of a TenLV pseudot...

journal_title：Journal of virology

authors： Eckner RJ

更新日期：1973-09-01 00:00:00

abstract：:Normal levels of the hypermodified pyrimidine, alpha-putrescinylthymine, which is formed from hydhydroxymethyluracil at the polynucleotide level (Maltman et al., J. Virol. 34:354-359, 1984), are not required in bacteriophage luminal diameterW-14 DNA for the DNA to serve as a replicative template in luminal diameterW-1...

journal_title：Journal of virology

authors： Miller PB,Warren RA

更新日期：1984-12-01 00:00:00

abstract：:The required activities of CD4(+) T cells and antibody against the virally encoded oncoprotein simian virus 40 (SV40) Tag have previously been demonstrated by our laboratory to be mediators in achieving antitumor responses and tumor protection through antibody-dependent cell-mediated cytotoxicity (ADCC). In this study...

journal_title：Journal of virology

authors： Lowe DB,Shearer MH,Jumper CA,Bright RK,Kennedy RC

更新日期：2010-01-01 00:00:00

abstract：:Natural killer T (NKT) cells are unique T lymphocytes that recognize CD1d-bound lipid antigens and play an important role in both innate and acquired immune responses against infectious diseases and tumors. We have already shown that a vesicular stomatitis virus (VSV) infection results in the rapid inhibition of murin...

journal_title：Journal of virology

authors： Renukaradhya GJ,Khan MA,Shaji D,Brutkiewicz RR

更新日期：2008-12-01 00:00:00

abstract：:The latent membrane protein 1 (LMP-1) of Epstein-Barr virus (EBV) functionally resembles a constitutively active, CD40-like receptor and contributes to the maintenance of proliferation of EBV-infected primary human B lymphocytes. LMP-1 is targeted to the plasma membrane, where it binds TRAF, TRADD, and JAK molecules t...

journal_title：Journal of virology

authors： Sandberg ML,Kaykas A,Sugden B

更新日期：2000-10-01 00:00:00

abstract：:One characteristic of all positive-strand RNA viruses is the necessity to assemble viral RNA replication complexes on host intracellular membranes, a process whose molecular details are poorly understood. To study viral replication complex assembly we use the established model system of Flock House virus (FHV), which ...

journal_title：Journal of virology

authors： Stapleford KA,Rapaport D,Miller DJ

更新日期：2009-05-01 00:00:00

abstract：:Papilloma virus DNA from a laryngeal papilloma was cloned in phage lambda L 47 and characterized after cleavage with different restriction enzymes. Hybridization with the DNAs of human papilloma virus types 1, 2, 3, 4, 5, and 8 showed no homology under stringent hybridization conditions. Human papilloma virus type 6 D...

journal_title：Journal of virology

authors： Gissmann L,Diehl V,Schultz-Coulon HJ,zur Hausen H

更新日期：1982-10-01 00:00:00

abstract：:During Epstein-Barr virus (EBV) latent infection of B lymphocytes in vitro, six viral nuclear antigens (EBNAs) are expressed from one of two promoters, Cp or Wp, whose activities have previously been shown to be mutually exclusive in established lymphoblastoid cell lines. Initially after infection, the EBNA genes are ...

journal_title：Journal of virology

authors： Yoo LI,Mooney M,Puglielli MT,Speck SH

更新日期：1997-12-01 00:00:00

abstract：:Experiments were conducted to investigate the roles of Marek's disease virus serotype 1 (MDV-1) major tegument proteins VP11/12, VP13/14, VP16, and VP22 in viral growth in cultured cells. Based on a bacterial artificial chromosome clone of MDV-1 (BAC20), mutant viruses were constructed in which the MDV-1 homologs of U...

journal_title：Journal of virology

authors： Dorange F,Tischer BK,Vautherot JF,Osterrieder N

更新日期：2002-02-01 00:00:00

abstract：:The protein kinase C (PKC) pathway has been considered to be essential for activation of latent Epstein-Barr virus (EBV) into the lytic cycle. The phorbol ester tetradecanoyl phorbol acetate (TPA), a PKC agonist, is one of the best understood activators of EBV lytic replication. Zp, the promoter of the EBV immediate-e...

journal_title：Journal of virology

authors： Gradoville L,Kwa D,El-Guindy A,Miller G

更新日期：2002-06-01 00:00:00

abstract：:Published work (D. J. McGeoch, Nucleic Acids Res. 18:4105-4110, 1990; J. E. McGeehan, N. W. Depledge, and D. J. McGeoch, Curr. Protein Peptide Sci. 2:325-333, 2001) has indicated that evolution of dUTPase in the class of herpesviruses that infect mammals and birds involved capture of a host gene followed by a duplicat...

journal_title：Journal of virology

authors： Davison AJ,Stow ND

更新日期：2005-10-01 00:00:00

abstract：:Reovirus encephalitis in mice was used as a model system to investigate astrocyte activation (astrogliosis) following viral infection of the brain. Reovirus infection resulted in astrogliosis, as evidenced by increased expression of glial fibrillary acidic protein (GFAP), and the upregulation of genes that have been p...

journal_title：Journal of virology

authors： Clarke P,Zhuang Y,Berens HM,Leser JS,Tyler KL

更新日期：2019-05-01 00:00:00

abstract：:A comparison has been made of the membrane glycoproteins and glycopeptides from two enveloped viruses, Sindbis virus and vesicular stomatitis virus (VSV). Glycopeptides isolated from Sindbis virus and VSV grown in the same host appear to differ principally in the number of sialic acid residues per glycopeptide; when s...

journal_title：Journal of virology

authors： Burge BW,Huang AS

更新日期：1970-08-01 00:00:00

abstract：:Equine herpesvirus type 1 (EHV-1), a member of the Alphaherpesviridae, displays a broad host range in vitro, allowing for detailed study of the mechanisms of productive infection, including attachment and entry, in various cell culture systems. Previously, we showed that EHV-1 infects Chinese hamster ovary (CHO-K1) ce...

journal_title：Journal of virology

authors： Frampton AR Jr,Stolz DB,Uchida H,Goins WF,Cohen JB,Glorioso JC

更新日期：2007-10-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is a human herpesvirus capable of establishing a latent state in B lymphocytes. EBV's BZLF1 gene product plays a central role in regulating the switch from latency to productive infection. Here, we identify a sequence element, 5'-CAGGTA-3', called ZV, located at nucleotides -17 to -12 relative...

journal_title：Journal of virology

authors： Kraus RJ,Mirocha SJ,Stephany HM,Puchalski JR,Mertz JE

更新日期：2001-01-01 00:00:00

abstract：:Adult T-cell leukemia (ATL) is a fatal malignancy of CD4+ T cells infected with human T-cell leukemia virus type 1 (HTLV-1). ATL cells often exhibit random gross chromosomal rearrangements that are associated with the induction and improper repair of double-stranded DNA breaks (DSBs). The viral oncoprotein Tax has bee...

journal_title：Journal of virology

authors： Rushing AW,Hoang K,Polakowski N,Lemasson I

更新日期：2018-07-17 00:00:00

abstract：UNLABELLED:The extreme stability of the latent HIV-1 reservoir in the CD4(+) memory T cell population prevents viral eradication with current antiretroviral therapy. It has been demonstrated that homeostatic T cell proliferation and clonal expansion of latently infected T cells due to viral integration into specific ge...

journal_title：Journal of virology

authors： Seu L,Sabbaj S,Duverger A,Wagner F,Anderson JC,Davies E,Wolschendorf F,Willey CD,Saag MS,Goepfert P,Kutsch O

更新日期：2015-07-01 00:00:00

abstract：:Receptors (FcgammaRs) for the constant region of immunoglobulin G (IgG) are an important link between humoral immunity and cellular immunity. To help define the role of FcgammaRs in determining the fate of human immunodeficiency virus type 1 (HIV-1) immune complexes, cDNAs for the four major human Fcgamma receptors (F...

journal_title：Journal of virology

authors： Perez LG,Costa MR,Todd CA,Haynes BF,Montefiori DC

更新日期：2009-08-01 00:00:00

abstract：:The relative contributions of interleukin-12 (IL-12) and IL-23 to viral pathogenesis have not been extensively studied. IL-12p40 mRNA rapidly increases after neurotropic coronavirus infection. Infection of mice defective in both IL-12 and IL-23 (p40(-/-)), in IL-12 alone (p35(-/-)), and in IL-23 alone (p19(-/-)) revea...

journal_title：Journal of virology

authors： Kapil P,Atkinson R,Ramakrishna C,Cua DJ,Bergmann CC,Stohlman SA

更新日期：2009-06-01 00:00:00

abstract：:Klebsiella pneumoniae is a member of the family Enterobacteriaceae, opportunistic pathogens that are among the eight most prevalent infectious agents in hospitals. The emergence of multidrug-resistant strains of K. pneumoniae has became a public health problem globally. To develop an effective antimicrobial agent, we ...

journal_title：Journal of virology

authors： Cui Z,Shen W,Wang Z,Zhang H,Me R,Wang Y,Zeng L,Zhu Y,Qin J,He P,Guo X

更新日期：2012-12-01 00:00:00

abstract：:RNA structures play key roles in the replication of RNA viruses. Sequence alignment software, thermodynamic RNA folding programs, and classical comparative phylogenetic analysis were used to build models of six RNA elements in the coding region of the hepatitis C virus (HCV) RNA-dependent RNA polymerase, NS5B. The imp...

journal_title：Journal of virology

authors： You S,Stump DD,Branch AD,Rice CM

更新日期：2004-02-01 00:00:00

abstract：UNLABELLED:The HIV-1 envelope protein (Env) is heavily glycosylated, with approximately 50% of the Env molecular mass being contributed by N-glycans. HIV-1 Env N-glycans shield the protein backbone and have been shown to play key roles in determining Env structure, surface exposure, and, consequently, antigenicity, inf...

journal_title：Journal of virology

authors： Shen R,Raska M,Bimczok D,Novak J,Smith PD

更新日期：2014-12-01 00:00:00

abstract：:After rabies virus glycoprotein was treated with CNBr, the peptide mixture was fractionated by preparative sodium dodecyl sulfate-polyacrylamide gel electrophoresis. CNBr-cleaved peptide fragments were resolved into seven peptide bands under reducing conditions and six peptide bands under nonreducing conditions. The i...

journal_title：Journal of virology

authors： Dietzschold B,Wiktor TJ,Macfarlan R,Varrichio A

更新日期：1982-11-01 00:00:00

abstract：:Therapeutic suppression of human immunodeficiency virus type 1 (HIV-1) replication may help elucidate interactions between the host cellular immune responses and HIV-1 infection. We performed a detailed longitudinal evaluation of two subjects before and after the start of highly active antiretroviral therapy (HAART). ...

journal_title：Journal of virology

authors： Kalams SA,Goulder PJ,Shea AK,Jones NG,Trocha AK,Ogg GS,Walker BD

更新日期：1999-08-01 00:00:00

abstract：:Cytolytic T-lymphocyte (CTL) activity specific for respiratory syncytial (RS) virus was investigated after intranasal infection of mice with RS virus, after intraperitoneal infection of mice with a recombinant vaccinia virus expressing the F glycoprotein, and after intramuscular vaccination of mice with Formalin-inact...

journal_title：Journal of virology

authors： Nicholas JA,Rubino KL,Levely ME,Adams EG,Collins PL

更新日期：1990-09-01 00:00:00