Distinct cellular compartment of cyclin-dependent kinase 5 (Cdk5) and neuron-specific Cdk5 activator protein (p35nck5a) in the developing rat cerebellum.

abstract：:Two distinct families of low-molecular-weight toxins (argiotoxins) have been isolated from the venom of the orb-web spider. Argiope trifasciata. The toxins have been purified to homogeneity and characterised by spectroscopic, mass spectrometric and microchemical analysis. The major biologically active member of the fi...

journal_title：Brain research

authors： Budd T,Clinton P,Dell A,Duce IR,Johnson SJ,Quicke DL,Taylor GW,Usherwood PN,Usoh G

更新日期：1988-05-10 00:00:00

abstract：:Mice of the BALB/c strain were bilaterally implanted with electrodes in the lateral entorhinal cortex (EC) in order to study the influence of post-trial EC stimulation on memory. The learning task was a food reinforced operant conditioning. At one of several time intervals after a first learning session, the experimen...

journal_title：Brain research

authors： Gauthier M,Destrade C,Soumireu-Mourat B

更新日期：1982-02-11 00:00:00

abstract：:In zebra finches, androgens stimulate song production and promote growth of the neural regions controlling song. Early exposure to estrogen establishes this sensitivity to androgens and increases the number of androgen-accumulating cells in two song regions, the hyperstriatum ventralis pars caudalis (HVc) and the magn...

journal_title：Brain research

authors： Sohrabji F,Nordeen KW,Nordeen EJ

更新日期：1989-05-29 00:00:00

abstract：:The C-terminal flanking peptide of preprocholecystokinin (preproCCK) has been identified in extracts of rat brain using a novel radioimmunoassay. There is a single form of immunoreactive material on gel filtration, ion exchange and reversed-phase HPLC. The C-terminal preproCCK immunoreactivity had a similar pattern of...

journal_title：Brain research

authors： Varro A,Dockray GJ

更新日期：1986-06-18 00:00:00

abstract：:Cyclic nucleotide phosphodiesterase-4 (PDE4) is a component of signaling pathways involved in the mediation of antidepressant activity. Of the four PDE4 subtypes, PDE4D appears to be of particular importance, given the finding that PDE4D-deficient mice exhibit an antidepressant-like behavioral phenotype. In mouse hipp...

journal_title：Brain research

authors： Dlaboga D,Hajjhussein H,O'Donnell JM

更新日期：2006-06-22 00:00:00

abstract：:The healthy maturation of the brain is one of the intriguing topics that need to be investigated to understand human brain and child development. The present study aimed to investigate the development of memory processes both for auditory and visual memory using electroencephalography (EEG)-Brain Dynamics methodologie...

journal_title：Brain research

authors： Güntekin B,Uzunlar H,Çalışoğlu P,Eroğlu-Ada F,Yıldırım E,Aktürk T,Atay E,Ceran Ö

更新日期：2020-11-15 00:00:00

abstract：:To investigate the reversibility of neuronal functions during deep and mild hypothermia, we have examined changes in membrane properties of pyramidal neurons of the CA3 region of hippocampal slices during cooling and rewarming (8 approximately 37 degrees C) of the perfusion medium. Hypothermia reduced the excitatory p...

journal_title：Brain research

authors： Aihara H,Okada Y,Tamaki N

更新日期：2001-03-02 00:00:00

abstract：:c-Fos protein is a nuclear protein coded by c-fos proto-oncogene subsequent to synaptic activation of the neurons. We used immunohistochemical methods to visualize the expression of c-Fos protein in myenteric neurons of the guinea pig distal colon and examined the effects of the extrinsic autonomic inputs on the enter...

journal_title：Brain research

authors： Yuyama N,Mizuno J,Tsuzuki H,Wada-Takahashi S,Takahashi O,Tamura K

更新日期：2002-09-06 00:00:00

abstract：:Microinjection of apomorphine into the ventral tegmental area (VTA) of male rats was previously shown to delay the onset of copulation and slow its rate, presumably by stimulating impulse-regulating autoreceptors on cell bodies of the A10 mesocorticolimbic dopamine tract. Such stimulation would be expected to slow the...

journal_title：Brain research

authors： Hull EM,Weber MS,Eaton RC,Dua R,Markowski VP,Lumley L,Moses J

更新日期：1991-07-19 00:00:00

abstract：:Calpain, a Ca(2+)-dependent cysteine protease, has been implicated in cytoskeletal protein degradation and neurodegeneration in the lesion and adjacent areas following spinal cord injury (SCI). To attenuate apoptosis or programmed cell death (PCD) in SCI, we treated injured rats with E-64-d, a cell permeable and selec...

journal_title：Brain research

authors： Ray SK,Matzelle DC,Wilford GG,Hogan EL,Banik NL

更新日期：2000-06-09 00:00:00

abstract：:The distribution of alpha scorpion toxin (alpha-ScTx) receptors was examined in differentiated mouse neuroblastoma cell cultures (N IE 115 clone) by electron microscope autoradiography using [125I]alpha-ScTx. This neurotoxin binds specifically to voltage-sensitive sodium channels, slowing down the inactivation of the ...

journal_title：Brain research

authors： Cau P,Massacrier A,Boudier JL,Couraud F

更新日期：1985-05-13 00:00:00

abstract：:Striatal glial cell line-derived neurotrophic factor (GDNF) mRNA levels in both young (2-month old) and old (11-month old) C57BL/6J mice were quantified at 3, 7 and 21 days following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment. MPTP did not alter the expression of GDNF mRNA in these animals. Immunore...

journal_title：Brain research

authors： Inoue T,Tsui J,Wong N,Wong SY,Suzuki F,Kwok YN

更新日期：1999-05-01 00:00:00

abstract：:Development of noradrenergic responses in the rat dorsal motor nucleus of the vagus (DMV) from postnatal days 0 to 22 was studied by a conventional microelectrode technique using brain slice preparations. Between postnatal days 0 and 6, noradrenaline (NA) caused only alpha 1-adrenoceptor-mediated depolarizations. By p...

journal_title：Brain research

authors： Fukuda A,Nabekura J,Ito C,Plata-Salamán CR,Oomura Y

更新日期：1989-07-31 00:00:00

abstract：:Soluble epoxide hydrolase (sEH) is the major enzyme responsible for the metabolism and inactivation of epoxyeicosatrienoic acids (EETs). EETs are produced by the cytochrome P450 (CYP) epoxygenase pathway of arachidonic acid (AA) metabolism and tend to be anti-hypertensive, anti-inflammatory and protective against isch...

journal_title：Brain research

authors： Bianco RA,Agassandian K,Cassell MD,Spector AA,Sigmund CD

更新日期：2009-09-29 00:00:00

abstract：:To determine the contribution by mast cells to the brain content of histamine (HA) and its metabolite tele-methylhistamine (t-MH), the number of mast cells, as well as the levels of HA and t-MH were measured in brain regions of mast cell-deficient (W/Wv) and control (+/+) mice. In agreement with earlier studies, mast ...

journal_title：Brain research

authors： Hough LB,Khandelwal JK,Goldschmidt RC,Diomande M,Glick SD

更新日期：1984-01-30 00:00:00

abstract：:Many of our daily movements use visual information to guide our arms toward objects of interest. Typically, these visually guided movements involve first focusing our gaze on the intended target and then reaching toward the direction of our gaze. The literature on eye-hand coordination provides a great deal of evidenc...

journal_title：Brain research

authors： Gorbet DJ,Sergio LE

更新日期：2009-08-11 00:00:00

abstract：:In an attempt to determine the basis for apparently conflicting reports of the effects of noradrenaline (NA) on the neurohypophyseal system and its effects on the parvocellular periventricular region of the paraventricular nucleus (PVN), recordings were made from the neurons in the supraoptic nucleus (SON) and the per...

journal_title：Brain research

authors： Inenaga K,Dyball RE,Okuya S,Yamashita H

更新日期：1986-03-26 00:00:00

abstract：:Hyperprolinemia type II is an autosomal recessive disorder caused by the severe deficiency of delta(1)-pyrroline-5-carboxylate dehydrogenase activity leading to tissue accumulation of proline (Pro). Most patients detected so far show neurological manifestations including epilepsy and mental retardation, whose pathophy...

journal_title：Brain research

authors： Delwing D,Bavaresco CS,Chiarani F,Wannmacher CM,Wajner M,Dutra-Filho CS,de Souza Wyse AT

更新日期：2003-11-21 00:00:00

abstract：:Neurointermediate lobes of rats comprise elements which, when excited in vitro, bring about an inhibition of the release of melanocyte stimulating hormone (MSH). Superfusion of neurointermediate lobes of intact donor rats with medium containing 45 mM K+ induced a stimulation of the release of oxytocin, arginine-vasopr...

journal_title：Brain research

authors： Tilders FJ,van der Woude HA,Swaab DF,Mulder AH

更新日期：1979-08-10 00:00:00

abstract：:Both direct pituitary and indirect CNS mechanisms have been postulated for the influence of opiate agonists on prolactin secretion. By examining the interactions between terminals of neurons containing opioid peptides and hypothalamic TH-positive cell bodies, this paper addressed the anatomical basis for the latter me...

journal_title：Brain research

authors： Fitzsimmons MD,Olschowka JA,Wiegand SJ,Hoffman GE

更新日期：1992-05-22 00:00:00

abstract：:A major function of the dopamine in the striatum is to control the activity of its efferent systems which contain primarily GABAergic neurons. Direct intracerebral injections of haloperidol into the corpus striatum impaired the performance of rats trained to depress a lever in a sensitive reaction time task. Rats were...

journal_title：Brain research

authors： Amalric M,Koob GF

更新日期：1989-04-03 00:00:00

abstract：:We have previously observed that chronic cocaine administration increases levels of adenylyl cyclase and cAMP-dependent protein kinase (PKA) in the nucleus accumbens (NAc). In the present work we directly examined the involvement of the cAMP system at the level of the NAc in cocaine-induced locomotor activity and sens...

journal_title：Brain research

authors： Miserendino MJ,Nestler EJ

更新日期：1995-03-20 00:00:00

abstract：:The effects of chronic treatment of rats with RWJ 37796, a novel aryl-piperazine containing antipsychotic drug, on brain monoamine receptors were studied. Rats were treated daily with RWJ 37796 (1.3 mg/kg), the typical antipsychotic haloperidol (1 mg/kg) or vehicle (control) for 21 days, and were sacrificed 3 days aft...

journal_title：Brain research

authors： Shapiro LA,Offord SJ,Ordway GA

更新日期：1995-04-24 00:00:00

abstract：:The postnatal development of the terminal Schwann cell, an analogue of the lamellar cell in cutaneous sensory receptors, was examined by histochemistry for non-specific cholinesterase and immunohistochemistry for S-100 protein in the periodontal Ruffini endings of the rat incisor. Double immunohistochemistry for S-100...

journal_title：Brain research

authors： Hayashi S,Nakakura-Ohshima K,Ohshima H,Noda T,Honma S,Wakisaka S,Maeda T

更新日期：2000-03-06 00:00:00

abstract：:Effects of lateral vestibular nucleus (LVN) stimulation on neuronal activity in the rat lateral hypothalamic area (LHA), including specific glucose-sensitive neurons, were investigated by extracellular and intracellular recordings in vivo. Stimulation of the contralateral LVN evoked 3 types of response in 46% (111/240...

journal_title：Brain research

authors： Katafuchi T,Puthuraya KP,Yoshimatsu H,Oomura Y

更新日期：1987-01-01 00:00:00

abstract：:To determine whether the idiosyncratic distribution of transduction mechanisms for bitter tastants in rat taste receptor cells (TRCs) could be inferred from the neural activity they evoke, single neuron responses to ten bitter-tasting compounds were recorded from rat glossopharyngeal (n = 30) and chorda tympani (n = 2...

journal_title：Brain research

authors： Dahl M,Erickson RP,Simon SA

更新日期：1997-05-09 00:00:00

abstract：:The mesolimbic dopamine (DA) system has long been known to be involved in reward behaviors. As with other substances of abuse, it has been extensively reported that ethanol influences the dopaminergic system. The present study examined whether selectively bred Sardinian-alcohol-preferring (sP) and Sardinian alcohol no...

journal_title：Brain research

authors： Casu MA,Colombo G,Gessa GL,Pani L

更新日期：2002-01-11 00:00:00

abstract：:The non-cholinergic excitatory potential elicited in neurons of the isolated inferior mesenteric ganglia was depressed by bath application of Met- or Leu-enkephalin and enhanced by naloxone or naltrexone. The membrane depolarization induced by exogenously applied putative transmitter substance P was not appreciably af...

journal_title：Brain research

authors： Jiang ZG,Simmons MA,Dun NJ

更新日期：1982-03-04 00:00:00

abstract：:Cell transplantation using ventral mesencephalic tissue is an experimental approach to treat Parkinson's disease. This approach is limited by poor survival of the transplants and the high number of dopaminergic neurons needed for grafting. Increasing the yield of dopaminergic neurons in donor tissue is of great import...

journal_title：Brain research

authors： Seiler S,Di Santo S,Sahli S,Andereggen L,Widmer HR

更新日期：2017-08-01 00:00:00

abstract：:Unilateral injections of 6-hydroxydopamine into the lateral hypothalamus or ventral tegmental area that damage extensively the mesotelencephalic dopaminergic projection result in significant hemispheric asymmetries in autoradiographic labeling after [14C]2-deoxy-D-glucose (2DG) administration. The incorporation of thi...

journal_title：Brain research

authors： Kozlowski MR,Marshall JF

更新日期：1980-09-15 00:00:00